Researches

Research Publishes (主題研究發表)
I. Hydrogels (水膠材料開發)

本主題研究內容包括
1) 生物性水膠材料：骨組織工程、抗沾黏薄膜、人工敷料開發等
2) 非生物性水膠/矽水膠：隱形眼鏡、人工導管

• A novel γ-PGA composite gellan membrane containing glycerol for guided bone regeneration, Materials Science and Engineering C 118(2021)111404.

• Glycerol-modified γ-PGA and gellan composite hydrogel materials with tunable physicochemical and thermal properties for soft tissue engineering application, Polymer 230(2021)124049.

• Dual RGD-immobilized Poly(L-lactic acid) by Atmospheric Pressure Plasma Jet for Bone Tissue Engineering, Colloids and Surfaces B: Biointerfaces 178 (2019) 358-364.

II. Mineralization of inorganic particle on bio-based membrane surface

本主題研究內容包括
1) 礦化結構加工：礦化裝置設計、材料表面礦化處理、骨組織工程應用
2) 表面處理技術：材料表面加工技術、材料結構分析技術

• Hydroxyapatite -mineralized on polyelectrolytes layer-by-layer-coated poly (lactic acid) nanofiber sheets for bone tissue engineering, Biomaterials Science BM-ART-09-2020-001671

• Using calcium silicate to regulate the physicochemical and biological properties when using β-tricalcium phosphate as bone cement, Materials Science and Engineering C 43(2014)126-134.

• Odontogenic differentiation of human dental pulp cells by calcium silicate materials stimulating via FGFR/ERK signaling pathway, Materials Science and Engineering C 43(2014)359-366.

III. Electrospinning (高壓電紡奈米纖維技術)

本主題研究內容包括
1) 高壓電紡技術：奈米纖維薄膜製作、不同膠體材質奈米纖維薄膜成型技術、多維度奈米纖維膜加工
2) 電紡薄膜開發：骨組織工程、人工敷料、人工廔管開發應用

• Production, Optimization and Characterization of Polylactic Acid Microparticles using Electrospray with Porous Structure, Applied Sciences-Nanotechnology and Applied Nanosciences section, 11(2021)5090

• Preparation and characterization of electrospun polylactic acid/sodium alginate/orange oyster shell composite nanofiber for biomedical application. Journal of the Australian Ceramic Society 56 (2020) 533–543.

• Novel Electrospun Polycaprolactone/Graphene Oxide/Fe₃O₄ Nanocomposites for Biomedical Applications. Colloids and Surfaces B: Biointerfaces 172 (2018)718-727.

• A novel antibacterial nanofibers mat made of co-axial electrospun polycaprolactone/ silver nitrate/zinc oxide composites. Advanced Nano-Bio-Materials and Devices 2(2018) 275­-286.

IV. Surface modification of nanofiber mat (奈米纖維膜表面加工)

本主題研究內容包括
1) 材料表面加工：物化性加工、表面電漿加工、表面生物性材料接枝處理
2) 複合混摻技術：有機無機材混摻、生物性材料複合加工

• Indocyanine green based fluorescent polymeric nanoprobes for in vitro imaging, Journal of Biomedical Materials Research: Part B - Applied Biomaterials 108(2020)538-554.

• Dual RGD-immobilized Poly(L-lactic acid) by Atmospheric Pressure Plasma Jet for Bone Tissue Engineering, Colloids and Surfaces B: Biointerfaces 178 (2019)358-364.

• Encapsulation of indocyanine green (ICG) in poly(lactic acid) (PLA) nanofibers for using as a nanoprobe in biomedical diagnostics, Materials letter 228(2018)148–1511.

• Osteogenesis of human adipose-derived stem cells on poly(dopamine)-coated electrospun poly(lactic acid) fiber mats, Materials Science and Engineering C 58(2016)254-263.

• Chitosan-coated electrospun PLA fibers for rapid mineralization of calcium phosphate. International Journal of Biological Macromolecules 68(2014)39-47.

V. Surface enhanced Raman spectroscopy (拉曼光譜增顯技術)

本主題研究內容包括
1) 增顯奈米材料：二維奈米增顯基材、奈米星粒子、磁性奈米粒合成與性質分析
2) 奈米增顯粒子表面抗體接枝：表面抗體修飾技術、分子探針最佳化

• High efficiency SERS detection of clinical microorganism by low cost silver-mirror reacted filter membrane and pattern recognition techniques. Sensors and acuators B 241(2017)1–9.

• AuNPs@mesoSiO₂ composites for SERS detection of DTNB molecule. Biosensors and Bioelectronics 51(2014)297-303.

• A filter-like AuNPs@mesoSiO₂ SERS substrate for S. aureus detection. Biosensors and Bioelectronics 53(2014)519-527.

VI. Clinical infectious and microorganism detection (臨床感染微生物快速檢測 )

本主題研究內容包括
1) 感染微生物快速檢測：微生物光譜指紋檢測技術、噬菌體檢測分析、角膜潰瘍感染檢測、腹膜透析感染檢測
2) 微生物指紋分型技術：感染微生物快速分型、微量檢體分析技術、光譜指紋增顯技術

• Tracking the Reflective Light Particles Spreading on the Cornea: An Emerging Assessment for Tear Film Homeostasis. Translational Vision Science & Technology 32(2019)1-9.

• Differentiation between Infectious and Non-infectious Ulcerative Keratitis by Raman Spectra of Human Teardrops: A Pilot Study, Investigative Ophthalmology & Visual Science 53(2012)1436-44.

• Tear Analytical Model Based on Raman Microspectroscopy for Investigation of Infectious Diseases of Ocular Surface, Investigative Ophthalmology & Visual Science 52(2011)4942-50.

• A filter-like AuNPs@mesoSiO₂ SERS substrate for S. aureus detection. Biosensors and Bioelectronics 53(2014)519-527.

• Rapid Discrimination of Bacteria and Bacteriophages by Raman Spectroscopy, Applied Mechanics and Material 284-287(2013)523-527

• Discrimination of Clinical Microorganism using Raman Spectroscopy and Pattern Recognition Techniques, World Congress on Engineering 2(2017) 1081-1084.