Shih-Kai Chu 朱是鍇
Shih-Kai Chu 朱是鍇
Department of Statistics, National Taipei University
151, University Rd., Sanxia Dist., New Taipei City 237303, Taiwan R.O.C.
TEL: +886-2-86741111 ext. 66779
E-mail: uhcnivag@gm.ntpu.edu.tw
Department of Statistics, National Taipei University
151, University Rd., Sanxia Dist., New Taipei City 237303, Taiwan R.O.C.
TEL: +886-2-86741111 ext. 66779
E-mail: uhcnivag@gm.ntpu.edu.tw
Statistical Genetics, Genetic data analysis
Rapid development of biomedical data profiling techniques has prompted unprecedented growth of data science in medicine. Shih-Kai's research focuses on studying statistical and computational methods in high-dimensional biomedical data analysis, and the results in human genetic data have showed (1) a guideline to select suitable noise reduction methods for single-cell RNA sequencing data; (2) computational algorithms to prioritize pathogenic variants for medical genetic data; (3) key genes associated with the treatment response in heroin-dependence patients or with interethnic effects in pharmaco-epigenetics. His current research conducts integrative analysis of genomic and medical imaging data by machine learning methods.
2010-2017 Ph.D., Bioinformatics Program, Taiwan International Graduate Program, Academia Sinica, Taiwan
2004-2006 M.S., Department of Statistics, National Taipei Uniersity, Taiwan
2000-2004 B.S., Department of Applied Mathematics, National Cheng-chi University, Taiwan
2023.08-present Assistant Professor; Department of Statistics,
National Taipai University, Taiwan
2021.09-2023.07 Postdoctoral Research Fellow; Institute of Statistical Science,
Academia Sinica, Taiwan
2020.11-2021.09 Assistant Research Fellow; Clinical Medicine Research Center,
National Cheng Kung University Hospital, Taiwan
2018.09-2020.08 Postdoctoral Research Fellow; Department of Biostatistics,
Vanderbilt University Medical Center, TN USA
2010.09-2018.01 Research Assistant; Institute of Statistical Science,
Academia Sinica, Taiwan
2008.09-2010.08 Research Assistant; Institute of Statistical Science,
Academia Sinica, Taiwan
2007.01-2007.09 Research Assistant; HIV/AIDS department,
Centers for Disease Control, Taiwan
(*Corresponding Author)
Ya-Ting Hsu, Li-Hsien Chen, Ya-Hui Liu, Shih-Kai Chu, Tsai-Yun Chen, Kuen-Jer Tsai, Meng-Ru Shen*, Wentai Liu*. Electrical Sympathetic Neuromodulation Protects Bone Marrow Niche and Drives Hematopoietic Regeneration during Chemotherapy. Small Methods. 7(6):e2201300, 2023 June
Meng-Che Tsai, Chih-Hui Hsu, Shih-Kai Chu, Marie-Hélène Roy-Gagnon, Sheng-Hsiang Lin*. Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene. Journal of Human Genetics. 68(5):339-345, 2023 May
Shih-Kai Chu, Shilin Zhao, Yu Shyr*, Qi Liu*. Comprehensive evaluation of noise reduction methods for single-cell RNA sequencing data. Briefings in Bioinformatics. 23(2):bbab565, 2022 March
Hsin-Chou Yang*, Chia-Wei Chen, Yu-Ting Lin, Shih-Kai Chu. Genetic ancestry plays a central role in population pharmacogenomics. Communications Biology. 4(1):171, 2021 February
Satya Das*, Kristen K. Ciombor, Sigurdis Haraldsdottir, Yoanna Pumpalova, Ibrahim H. Sahin, G. Pineda, Yu Shyr, E.P. Lin, Chih-Yuan Hsu, Shih-Kai Chu, Laura W. Goff, Dana B. Cardin, Mehmet A. Bilen, George A. Fisher, Christina Wu, Jordan Berlin. Immune‐Related Adverse Events and Immune Checkpoint Inhibitor Efficacy in Patients with Gastrointestinal Cancer with Food and Drug Administration‐Approved Indications for Immunotherapy. The Oncologist. 25(8):669-679, 2020 August
Shih-Kai Chu, Hsin-Chou Yang*. Interethnic DNA methylation difference and its implications in pharmacoepigenetics. Epigenomics. 9(11):1437-1454, 2017 November
Hsiang-Wei Kuo, Chia-Lung Shih, Jieh-Hen Tsung, Sheng-Wen Liu, Shih-Kai Chu, Hsin-Chou Yang, Hsiao-Hui Tsou, Zih-Hsiang Wang, Andrew C. H. Chen, Yu-Li Liu*. Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome. PLoS ONE. 12(3):e0174647, 2017 March
Hsin-Chou Yang, Shih-Kai Chu, Chieh-Liang Huang, Hsiang-Wei Kuo, Sheng-Chang Wang, Sheng-Wen Liu, Ing-Kang Ho, Yu-Li Liu*. Genome-wide pharmacogenomic study on methadone maintenance treatment identifies SNP rs17180299 and multiple haplotypes on CYP2B6, SPON1, and GSG1L associated with plasma concentrations of methadone R- and S-enantiomers in heroin-dependent patients. PLoS Genetics. 12(3):e1005910, 2016 March
Yi-Ting Hwang*, Shih-Kai Chu, Shyh-Tyan Ou. Evaluations of FDR-controlling procedures in multiple hypothesis testing. Statistics and Computing. 21:569–83, 2011 October