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IODINE-MEDIATED HYDRATION OF ALKYNES
IODINE-MEDIATED HYDRATION OF ALKYNES
Curr. Org. Syn. 2013, 11(3), 466-470.
Curr. Org. Syn. 2013, 11(3), 466-470.
The iodine-mediated hydration of internal alkynes is a novel, green, and inexpensive synthetic pathway in comparison with the commonly used transition metal catalyzed reactions. This experimental design has been used successfully on terminal alkynes and through systematic probing of the reaction conditions, we determined a strong mechanistic hypothesis based on neighboring group participation, a 5-exo-dig cyclization with the alkyne and keto units (above). Looking forward, our group is extending the scope of iodine-mediate reaction to other interesting substrates and tandem processes that take advantage of the reaction intermediates or hydrated products.
The iodine-mediated hydration of internal alkynes is a novel, green, and inexpensive synthetic pathway in comparison with the commonly used transition metal catalyzed reactions. This experimental design has been used successfully on terminal alkynes and through systematic probing of the reaction conditions, we determined a strong mechanistic hypothesis based on neighboring group participation, a 5-exo-dig cyclization with the alkyne and keto units (above). Looking forward, our group is extending the scope of iodine-mediate reaction to other interesting substrates and tandem processes that take advantage of the reaction intermediates or hydrated products.
CHEMOSENSORS
CHEMOSENSORS
New J. of Chem. 2015, 39 (1), 295-303.
New J. of Chem. 2015, 39 (1), 295-303.
Cations and anions are of great importance to biological and physiological processes and an imbalance in the concentration of any ion is harmful. Therefore, the ability to selectively recognize anions and cations is of great value. Our group proposes to address this issue with the design of chemosensors based on the 1,2,3-triazole scaffold, a motif for which its unique photophysical properties that can be tuned with structural modifications. Specifically, we are targeting 1,2,3-triazole sensors that provide intense color and fluorescent changes in response to their analytes. The sensors' structures and hence, their colorimetric/fluorometric recognition capabilities can be easily manipulated with straightforward synthetic approaches.
Cations and anions are of great importance to biological and physiological processes and an imbalance in the concentration of any ion is harmful. Therefore, the ability to selectively recognize anions and cations is of great value. Our group proposes to address this issue with the design of chemosensors based on the 1,2,3-triazole scaffold, a motif for which its unique photophysical properties that can be tuned with structural modifications. Specifically, we are targeting 1,2,3-triazole sensors that provide intense color and fluorescent changes in response to their analytes. The sensors' structures and hence, their colorimetric/fluorometric recognition capabilities can be easily manipulated with straightforward synthetic approaches.
This project is in collaboration with the labs of Debanjana Ghosh and Shainaz Landge.
This project is in collaboration with the labs of Debanjana Ghosh and Shainaz Landge.
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