Recent Publications


  • Fontelles CC, Santana da Cruz R, Gonsiewski AK, Barin E; Tekmen V, Jin L, Cruz MI, Loudig L, Warri A, de Assis S. Systemic alterations play a dominant role in epigenetic predisposition to breast cancer in offspring of obese fathers and is transmitted to a second generation. Scientific Reports 11:7317, 2021. [Pubmed]

  • da Cruz RS, Chen, E, Smith M, Bates J. and de Assis S. Diet and Transgenerational Epigenetic Inheritance of Breast Cancer: The Role of the Paternal Germline. Front. Nutr., 7:93, 2020. [PubMed]

  • da Cruz RS, Clarke J, Curi AC, Al-Yawar A, Jin L, Baird A, Cruz I, Kallakury BV, de Assis S: Parental obesity programs pancreatic cancer development in offspring. Endocr Relat Cancer. 2019 Mar 1. pii: ERC-19-0016.R1. doi: 10.1530/ERC-19-0016.[Pubmed]

  • da Cruz RS, Carney EJ, Clarke J, Cao H, Cruz MI, Benitez C, Jin L, Fu Y, Cheng Z, Wang Y, de Assis S: Paternal malnutrition programs breast cancer risk and tumor metabolism in offspring, Breast Cancer Res 2018, 20:99. [Pubmed]

  • Nguyen NM, de Oliveira Andrade F, Jin L, Zhang X, Macon M, Cruz MI, Benitez C, Wehrenberg B, Yin C, Wang X, Xuan J, de Assis S, Hilakivi-Clarke L. Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice. Breast Cancer Res. 2017 Jul 3;19(1):77. [PubMed]

  • Hilakivi-Clarke L, Wärri A, Bouker KB, Zhang X, Cook KL, Jin L, Zwart A, Nguyen N, Hu R, Cruz MI, de Assis S, Wang X, Xuan J, Wang Y, Wehrenberg B, Clarke R. Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model. J Natl Cancer Inst. 2016 Sep 8;109(1). [PubMed]

  • Fontelles CC, Guido LN, Rosim MP, Andrade FO, Jin L, Inchauspe J, Pires VC, de Castro IA, Hilakivi-Clarke L, de Assis S, Ong TP. Paternal programming of breast cancer risk in daughters in a rat model: opposing effects of animal- and plant-based high-fat diets. BioMed Cent 18:71 (2016). [PubMed]

  • Fontelles CC, Carney E, Clarke J, Nguyen NM, Yin C, Jin L, Cruz MI, Ong TP, Hilakivi-Clarke L, de Assis S. Paternal overweight is associated with increased breast cancer risk in daughters in a mouse model. Sci Rep 6 (2016): 28602. [PubMed]

  • Andrade F, Fontelles C, Rosim M; Oliveira T, Loureiro A, Filho J, Rogero M, Moreno F, de Assis S, Barbisan F, Hilakivi-Clarke L, Ong TP. Lipidomic fatty acid profile and global gene expression pattern in mammary gland of rats that were exposed to lard-based high fat diet during fetal and lactation periods associated to breast cancer risk in adulthood. Chem Biol Interact. 239:118-28, 2015.

  • Andrade F, Fontelles C, Rosim M; Oliveira T, Loureiro A, Filho J, Rogero M, Moreno F, de Assis S, Barbisan F, Hilakivi-Clarke L, Ong TP. Exposure to lard-based high-fat diet during fetal and lactation periods modifies breast cancer susceptibility in adulthood in rats. J Nutr Biochem. 25(6):613-22, 2014.

  • de Assis S, Wang M, Jin L, Bouker KB, and Hilakivi-Clarke L. Exposure to excess estradiol or leptin during pregnancy increases mammary cancer risk and prevents parity-induced protective genomic changes in rats. Cancer Prev Res. 6(11):1194-211, 2013.

  • de Assis S*, Warri A, Cruz MI, Laja O, Tian Y, Zhang B, Wang Y, Huang T, and Hilakivi-Clarke . High-fat or ethinyl-estradiol intake during pregnancy increases mammary cancer risk in several generations of offspring. Nat Commun. 3:1053, 2012. * corresponding author