PUBLICATIONS

Selected Publications

Chen L, Daniels S, Dvorak R, Chu HY. Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism. Sci Adv. 2023 Aug 25;9(34):eadg3038. doi: 10.1126/sciadv.adg3038. Epub 2023 Aug 23. PubMed PMID: 37611096; PubMed Central PMCID: PMC10446482.

Chen L, Nagaraja C, Daniels S, Fisk ZA, Dvorak R, Meyerdirk L, Steiner JA, Escobar Galvis ML, Henderson MX, Rousseaux MWC, Brundin P, Chu HY. Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala. Elife. 2022 Jul 1;11. doi: 10.7554/eLife.78055. PubMed PMID: 35775627; PubMed Central PMCID: PMC9286736.

Chen L, Daniels S, Kim Y, Chu HY. Cell Type-Specific Decrease of the Intrinsic Excitability of Motor Cortical Pyramidal Neurons in Parkinsonism. J Neurosci. 2021 Jun 23;41(25):5553-5565. doi: 10.1523/JNEUROSCI.2694-20.2021. Epub 2021 May 18. PubMed PMID: 34006589; PubMed Central PMCID: PMC8221604.

Zhen XC, Chu HY. Emerging novel approaches to drug research and diagnosis of Parkinson's disease. Acta Pharmacol Sin. 2020 Apr;41(4):439-441. doi: 10.1038/s41401-020-0369-7. Epub 2020 Mar 13. PubMed PMID: 32203079; PubMed Central PMCID: PMC7471400.

Chu HY. Synaptic and cellular plasticity in Parkinson's disease. Acta Pharmacol Sin. 2020 Apr;41(4):447-452. doi: 10.1038/s41401-020-0371-0. Epub 2020 Feb 28. Review. PubMed PMID: 32112041; PubMed Central PMCID: PMC7470833.

McIver EL, Atherton JF, Chu HY, Cosgrove KE, Kondapalli J, Wokosin D, Surmeier DJ, Bevan MD. Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons. Cell Rep. 2019 Jul 23;28(4):992-1002.e4. doi: 10.1016/j.celrep.2019.06.076. PubMed PMID: 31340159; PubMed Central PMCID: PMC6699776.

Chu HY, McIver EL, Kovaleski RF, Atherton JF, Bevan MD. Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons. Neuron. 2017 Sep 13;95(6):1306-1318.e5. doi: 10.1016/j.neuron.2017.08.038. PubMed PMID: 28910619; PubMed Central PMCID: PMC5679443.

Chu HY, Atherton JF, Wokosin D, Surmeier DJ, Bevan MD. Heterosynaptic regulation of external globus pallidus inputs to the subthalamic nucleus by the motor cortex. Neuron. 2015 Jan 21;85(2):364-76. doi: 10.1016/j.neuron.2014.12.022. Epub 2015 Jan 8. PubMed PMID: 25578364; PubMed Central PMCID: PMC4304914.

Zhou SL, Chu HY, Jin GZ, Cui JM, Zhen XC. Effects of SKF83959 on the excitability of hippocampal CA1 pyramidal neurons: a modeling study. Acta Pharmacol Sin. 2014 Jun;35(6):738-51. doi: 10.1038/aps.2014.23. Epub 2014 May 26. PubMed PMID: 24858313; PubMed Central PMCID: PMC4086385.

Chu HY, Ito W, Li J, Morozov A. Target-specific suppression of GABA release from parvalbumin interneurons in the basolateral amygdala by dopamine. J Neurosci. 2012 Oct 17;32(42):14815-20. doi: 10.1523/JNEUROSCI.2997-12.2012. PubMed PMID: 23077066; PubMed Central PMCID: PMC3491568.

Chu HY, Wu Q, Zhou S, Cao X, Zhang A, Jin GZ, Hu GY, Zhen X. SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism. J Neurosci Res. 2011 Aug;89(8):1259-66. doi: 10.1002/jnr.22653. Epub 2011 May 2. PubMed PMID: 21538463.

Gao M, Chu HY, Jin GZ, Zhang ZJ, Wu J, Zhen XC. l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity. Synapse. 2011 May;65(5):379-87. doi: 10.1002/syn.20855. Epub 2010 Sep 24. PubMed PMID: 20803620.

Chu HY, Gu Q, Jin GZ, Hu GY, Zhen X. Electrophysiological effects of SKF83959 on hippocampal CA1 pyramidal neurons: potential mechanisms for the drug's neuroprotective effects. PLoS One. 2010 Oct 1;5(10). doi: 10.1371/journal.pone.0013118. PubMed PMID: 20957037; PubMed Central PMCID: PMC2948503.

Chu HY, Zhen X. Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels in the regulation of midbrain dopamine systems. Acta Pharmacol Sin. 2010 Sep;31(9):1036-43. doi: 10.1038/aps.2010.105. Epub 2010 Aug 2. Review. PubMed PMID: 20676119; PubMed Central PMCID: PMC4002296.

Chu HY, Yang Z, Zhao B, Jin GZ, Hu GY, Zhen X. Activation of phosphatidylinositol-linked D1-like receptors increases spontaneous glutamate release in rat somatosensory cortical neurons in vitro. Brain Res. 2010 Jul 9;1343:20-7. doi: 10.1016/j.brainres.2010.04.043. Epub 2010 Apr 24. PubMed PMID: 20420815.