Book Chapter:

1.  Chang, Y.J. and Chen, Y.R.* (2017). “Folding and Misfolding of Amyloid-β 40 and 42 in Alzheimer’s Disease” in Yuan, J.M and Zhou, H.X. (Ed.), "Biophysics and biochemistry of protein aggregation". Singapore, World Scientific. 

Conference Publication:

2.  Yun-Ru Chen*.  Publications in current position: 

1. Tien-Ying Tsai , Chun-Yu Chen , Tien-Wei Lin , Tien-Chang Lin , Feng-Lan Chiu , Orion Shih , Ming-Yun Chang , Yu-Chun Lin , An-Chung Su, Chiung-Mei Chen, U-Ser Jeng, Hung-Chih Kuo, Chi-Fon Chang and Yun-Ru Chen*. Amyloid modifier SERF1a interacts with polyQ-expanded huntingtin-exon 1 via helical interactions and exacerbates polyQ-induced toxicity. Communications Biology 6 (1):767 (2023)

2. Wan-Chin Chiang, Yu-Sheng Fang, Yuh Shen Lye, Tzu-Yu Weng, Tzu-Yu Weng, Kiruthika Ganesan, Shih-Han Huang, Lan-Yun Chang, Shih-Chieh Chou, and Yun-Ru Chen*. Hyperphosphorylation-Mimetic TDP-43 Drives Amyloid Formation and Possesses Neuronal Toxicity at the Oligomeric Stage. ACS Chem. Neurosci. 13, 17 (2022)

3.  Jin-Lin Wu, Tung-Hung Su, and Yun-Ru Chen*. Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level. Scientific Reports. 12:5799 (2022)

4. Yuh Shen Lye and Yun-Ru Chen*. TAR DNA-binding protein 43 oligomers in physiology and pathology. IUBMB Life 74:794 (2022)

5. Yao-Hsiang Shih§, Ling-Hsien Tu§, Ting-Yu Chang, Kiruthika Ganesan, Pao-Sheng Chang, Yu-Sheng Fang, Yeh-Tung Lin, Lee-Way Jin, and Yun-Ru Chen*. TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens Alzheimer’s disease pathology. Nature Communications. 11: 5950 (2020) 

6. Ling-Hsien Tu, Ning-Hsuan Tseng, Ya-Ru Tsai, Tien-Wei Lin, Yi-Wei Lo, Jien-Lin Charng, Hua-Ting Hsu, Yu-Sheng Chen, Rong-Jie Chen, Ying-Da Wu, Yi-Tsu Chan, Chang-Shi Chen, Jim-Min Fang,* and Yun-Ru Chen*. Rationally Designed Divalent Caffeic Amide Inhibits Amyloid-β Fibrillization, Induce Fibril Dissociation, and Ameliorate Cytotoxicity. European Journal of Medicinal Chemistry. 158: 393-404 (2018) 

7. Chia-Jung Kuo, Hsu-Cheng Chiang, Chi-Ang Tseng, Chin-Fu Chang, Rajesh Kumar Ulaganathan, Tzu-Ting Ling, Yu-Jen Chang, Chiao-Chen Chen, Yun-Ru Chen, and Yit-Tsong Chen*. A Lipid-Modified Graphene-Transistor Biosensor for Monitoring Amyloid-β Aggregation. ACS Applied Materials & Interfaces. 10(15):12311-12316 (2018) (IF=7.504, times cited=1)

8. Ming-Che Lee, Wan-Cheng Yu, Yao-Hsiang Shih, Chun-Yu Chen, Zhong-Hong Guo, Shing-Jong Huang, Jerry C. C. Chan, and Yun-Ru Chen*. Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease. Scientific Reports 8, Article number: 4772 (2018) (IF=4.259, times cited=1) 

9. Tien-Wei Lin, Chi-Fon Chang, Yu-Jen Chang, Yi-Hung Liao, Hui-Ming Yu, and Yun-Ru Chen*. Alzheimer’s Amyloid-β A2T Variant  and its N-terminal Peptides Inhibit Amyloid-β Fibrillization and Rescue the Induced Cytotoxicity. (2017) PLoS One. 12(3):e0174561.(IF=2.806,times cited=8)

10. Smethurst, Phillip*; Newcombe, Jia; Troakes, Claire;Simone, Roberto; Wadsworth, John; Hardy, John; Chen, Yun-Ru; Patani, Rickie; Sidle, Katie. In vitro prion-like mechanisms of TDP-43 in ALS. (2016) Neurobiology of Disease, 96:236-247 (IF=4.856, times cited=0)

11.  Nguyen Quoc Thai, Ning-Hsuan Tseng, Mui Thi Vu, Tin Trung Nguyen, Huynh Quang Linh, Chin-Kun Hu*, Yun-Ru Chen*, and Mai  Suan Li*. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for Alzheimer’s disease: in silico and in vitro study.     (2016) Journal of Computer-Aided Molecular Design, Aug;30(8):639-50. (IF=3.199, times cited=0)

12. Yu-Jen Chang, Nguyen Hoang Linh, Hui-Ming Yu, Mai Suan Li*, and Yun-Ru Chen*. Alzheimer’s Amyloid-β Sequesters  Caspase-3  in vitro via its C-terminal Tail. (2016) ACS Chemical Neuroscience, 7(8):1097-106 (IF=4.384, times cited=0)

13. Yu-Jen Chang, U-Ser Jeng, Ya-Ling Chiang, Ing-Shouh Hwang, and Yun-Ru Chen*. Glycine-Alanine Dipeptide Repeat from C9orf72 Hexanucleotide Expansions Forms Toxic Amyloids Possessing Cell-to-cell Transmission Property. (2016) J Biol. Chem.,  291(10):4903-11. (IF=4.258, times cited=7)

14. Chia‑Wei Lee, Lan‑Ling Jang, Huei‑Jyuan Pan, Yun‑Ru Chen, Chih‑Cheng Chen, and Chau‑Hwang Lee. “Membrane roughness as a sensitive parameter reflecting the status of neuronal cells in response to chemical and nanoparticle treatments”. (2016) Journal of Nanobiotechnology, 14:9. (IF=4.239, times cited=0)

15. Yi-Hung Liao and Yun-Ru Chen*. A novel method for expression and purification of authentic amyloid-β with and without 15N labels. (2015) Protein expression and purification, 113, 63-71. (IF=1.407, times cited=1)

16. Patricia F. Kao, Yun-Ru Chen, Xiao-Bo Liu, Charles DeCarli, William W. Seeley, and Lee-Way Jin*. Detection of TDP-43 oligomers in frontotemporal lobar degeneration-TDP. (2015)(Annals of Neurology, 78(2):211-21). (IF=9.638; times cited=4) 

17. Yu-Sheng Fang, Kuen-Jer Tsai, Yu-Jen Chang, Patricia Kao, Rima Woods, Pan-Hsien Kuo, Cheng-Chun Wu, Jhih-Ying Liao, Shih- Chieh Chou, Vinson Lin, Lee-Way Jin, Hanna S. Yuan, Irene H Cheng, Pang-Hsien Tu, and Yun-Ru Chen*. “Full-Length TDP-43     Forms Toxic Amyloid Oligomers that are Present in Frontotemporal Lobar Dementia-TDP Patients.” (*corresponding author) (2014) Nature Communications, 5:4824, 1-13. (IF=11.329; times cited=28, R/C=3/63, Multidisciplinary Sciences)

18.  Yu-Jen Chang and Yun-Ru Chen*. The Co-existence of an Equal Amount of Alzheimer’s Amyloid-β 40 and 42 forms Structurally Stable and Toxic Oligomers through a Distinct Pathway. (*corresponding author) (2014), FEBS Journal, 281, 2674-2687. (IF=4.237, times cited=14, R/C=72/289, Biochemistry & Molecular Biology)

19. Huei-Jyuan Pan, Ruei-Lin Wang, Jian-Long Xiao, Yu-Jen Chang, Ji-Yen Cheng, Yun-Ru Chen, and Chau-Hwang Lee*. Using optical profilometry to characterize cell membrane roughness influenced by Amyloid-beta peptide and electric fields.  Journal of Biomedical Optics, 19 (1):011009. (2014)(IF=2.556, times cited=4)  

20. Man Hoang Viet, Chun-Yu Chen, Chin-Kun Hu, Yun-Ru Chen*, and Mai Suan Li*. Discovery of Dihydrochalcone as a potential lead  for Alzheimer’s disease: in silico and in vitro study. (*co-corresponding author) PLoS One, 8(11):e79151.(2013) (IF=3.057, times cited=12)

21. Wei-Chieh Cheng*, Chen-Yi Weng, Wen-Yi Yun, Shang-Yu Chang, Yu-Chun Lin, Fuu-Jen Tsai, Fu Yung Huang, Yun-Ru Chen. Rapid modifications of N-substitution in iminosugars: Development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease. (2013) Bioorganic & Medicinal Chemistry, 21(17) 5021-5028. (IF=2.923, times cited=11)

22. Rong-Jie Chen, Wei-Wei Chang, Yu-Chun Lin, Pei-Lin Cheng, and Yun-Ru Chen*. Alzheimer’s Amyloid-β Oligomers Rescue       Cellular Prion Protein Induced Tau Reduction via Fyn pathways. (*corresponding author). (2013) ACS Chemical Neuroscience, 4(9):1287-96. (IF=4.384, times cited=13, R/C=60/256,Neuroscience)

23. Yi-Ting Wang, Pan-Hsien Kuo, Chien-Hao Chiang, Jhe-Ruei Liang, Yun-Ru Chen, Shuying Wang, James C. K. Shen, and Hanna S. Yuan. The truncated C-terminal RRM domain of TDP-43 plays a key role in forming proteinaceous aggregates. (2013) J Biol. Chem., 288 (13), 9049-57. (IF=4.258, times cited=24) 

24. Winny Ariesandi, Chi-Fon Chang, Tseng-Erh Chen, and Yun-Ru Chen*. Temperature-dependent structural changes of Parkinson's  alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization. (*corresponding author). (2013) PLoS  One, 8(1):e53487. (IF=3.057, times cited=8)

25. Yi-Hung Liao, Yu-Jen Chang, Yuji Yoshiike, Yu-Chorng Chang*, and Yun-Ru Chen*. Negatively charged gold nanoparticles inhibit  Alzheimer’s amyloid-b fibrillization, induce fibril dissociation, and mitigate neurotoxicity. (*co-corresponding author). (Aug, 2012)  Small, 8, 23, 3631-3639. (IF=8.315, times cited=70, R/C=8/69, Nanoscience & Nanotechnology).

26. Wei-Ting Chen, Chen-Jee Hong, Ya-Tzu Lin, Wen-Han Chang, He-Ting Huang, Jhih-Ying Liao, Yu-Jen Chang, Yi-Fang Hsieh, Chih-Ya Cheng, Hsiu-Chih Liu, Yun-Ru Chen*, and Irene H Cheng *. Amyloid-beta (Ab) D7H mutation increases oligomeric Ab42  and alters properties of Ab-zinc/copper assemblies. (*co-corresponding author) (Apr., 2012) PLoS One, 7(4): e35807. (IF=3.057,  times cited=37, R/C=7/56, Multidisciplinary Sciences). 

27.      Chun-Lun Ni, Hoi-Ping Shi, Hui-Ming Yu, Yun-Chorng Chang, and Yun-Ru Chen*. Folding Stability of Amyloid-b40 Monomer is an Important Determinant of the Nucleation Kinetics in Fibrillization. (*corresponding author) (Apr., 2011) FASEB J., 25(4), 1390-401. (featured as a key scientific article in Global Medical Discovery) (IF=5.299, times cited=27, R/C=45/289, Biochemistry &    Molecular Biology) 

28. Wei-Ting Chen, Yi-Hung Liao, Hui-Ming Yu, Irene Cheng, and Yun-Ru Chen*. Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+ on Amyloid-b Stability, Oligomerization, and Aggregation: Amyloid-b Destabilization Promotes Annular Protofibril Formation. (*corresponding author) (Mar., 2011) J Biol. Chem., 286 (11), 9646-56. (IF=4.258; times cited=102, R/C=66/290, Biochemistry & Molecular Biology)

29. Ni-Shian Lin, John Ching-Hao Chao, Fang-Chieh Chou, Chi-Fon Chang, Yun-Ru Chen, Yu-Jen Chang, Shing-Jong Huang, Wei-Hsiang Tseng, and Jerry C. C. Chan. Molecular Structure of Amyloid Fibrils Formed by Residues 127 to 147 of the Human Prion Protein. (May, 2010) Chemistry - A European Journal, 16(18), 5492-9  (IF=5.771, times cited=15, R/C=18/147, Chemistry- Multidisciplinary)

30. Yuji Yoshiike, Ryoichi Minai, Yo Matsuo, Yun-Ru Chen, Tetsuya Kimura, Akihiko Takashima. Amyloid Oligomer Conformation in a Group of Natively Folded Proteins. (Sep., 2008) PLoS One, 3(9), e3235 (IF=3.057, times cited=57)

31. Yun-Ru Chen, Charles G. Glabe*. Distinct Early Folding and Aggregation Properties of Alzheimer Amyloid-β Peptide Aβ40 and Aβ42: Stable Trimer or Tetramer Formation by Aβ42. (Aug., 2006) J Biol. Chem., Aug 25;281(34):24414-22. (IF=5.808; times cited=172, R/C=39/262, Biochemistry & Molecular Biology)

32. Yun-Ru Chen, A. Clay Clark*. Substitutions of prolines examine their role in kinetic trap formation of the caspase recruitment domain (CARD) of RICK. (May, 2006) Protein Science. Mar;15(3):395-409 (IF=3.462, times cited=6, R/C=88/262, Biochemistry & Molecular Biology)

33. Yun-Ru Chen, A. Clay Clark*. Kinetic traps in the folding/unfolding of procaspase-1 CARD Domain. (May, 2004) Protein Science. Aug;13(8):2196-206. (IF=4.116, times cited = 18, R/C=61/261, Biochemistry & Molecular Biology )

34. Yun-Ru Chen, A. Clay Clark*. Equilibrium and Kinetic Folding of the α-Helical Greek Key Protein Domain: Caspase Recruitment Domain (CARD) of RICK. (May, 2003) Biochemistry, 42(20); 6310-6320. (IF=3.922, times cited = 19, R/C=59/261, Biochemistry & Molecular Biology)

35. Pop C, Chen YR, Smith B, Bose K, Bobay B, Tripathy A, Franzen S, Clark AC*. Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer. (Aug., 2001) Biochemistry. Nov 27; 40(47);14224-14235. (IF=4.114, times cited = 61, R/C=66/308, Biochemistry & Molecular Biology)

36. Y. Y. Charng, C. W. Sun, S. L. Yan, S. J. Chou, Y. R. Chen and S. F. Yang*. cDNA sequence of a putative ethylene receptor from carnation petals. (1997) Plant Physiol. 115. 863. (IF=3.618)inant TDP-43 Forms Toxic and Stable Amyloid-like Oligomers. Alzheimer's and Dementia, ISSN: 1552-5260, Vol: 6, Issue: 4, e44 (2010) 

Patent:

1.    US 9796778 B1. ANTIBODIES AGAINST PATHOLOGICAL FORMS OF TDP-43 AND USES THEREOF. Yun-Ru Chen. (2017.10.24-   

       2035.9.14)

2.    台灣專利 I592426.可辨識致病性TDP-43之抗體及其用途 (2017.7.21-2035.3.8)

3.     JP, CN, EU patent filing. 

Selected Presentations:

Invited Oral Presentations since 2006 (Talk abroad) (Invited Talk in Major Scientific Conferences)

1.        Oct. 2019 Asian Pacific Prion Sympsium .(RIKEN Center)Tokyo,Japan." Tau destabilization accelerates fibrillization and modulates the seeding template effect " 

2.        Jul. 2019. Academic and technical exchange(Japan,Tokyo)

3.        Mar. 14th,2019 International Conference on Alzheimer's & Parkinson's Diseases . Lisbon,Portugal (AD/PD2019)." TDP-43 INTERACTS WITH AMYLOID-ΒETA AND EXACERBATES PATHOLOGY OF ALZHEIMER DISEASE" 

4.        Jan. 2019.: RIKEN Symposium: Recent Progress in Protein Conformation and Aggregation. Tokyo,Japan"From Protein Misfolding to Translational Medical Research for Alzheimer's Disease and ALS "

5.        Dec. 2nd, 2018. Asian Biophysics Association Symposium (ABA2018). Melbourne, Australia. “Protein Misfolding and Therapeutics in Neurodegenerative Diseases”.

6.        Jul. 12th, 2017. The 5th Asia Pacific Protein Association Conference, 12th International Symposium of the Protein Society of Thailand. Bangsaen, Thailand. “Understanding Amyloids in Neurodegenerative Diseases”. 

7.        Apr. 1, 2017. The 13th International conference on Alzheimer’s and Parkinson’s diseases AD/PD 2017, Vienna, Austria. “Understanding TDP-43 Oligomers and Dipeptide Repeats in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis”

8.        Jan. 27, 2017. IPR Seminar / RIKEN Symposium / MEXT Kakenhi “Nascent Chain Biology: New Frontiers in Protein Misfolding and Aggregation, Osaka University, Osaka, Japan. “Understanding TDP-43 Oligomers and Dipeptide Repeats in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis” 

9.        Jan. 12, 2017. Inst. of Medical Sciences, Tzu Chi University, Hualien, Taiwan. “Understanding Amyloid Oligomers and Finding Opportunities toward Combating Neurodegenerative Diseases: Stories of Amyloid-β and TDP-43”

10.        Nov. 2, 2016. Dept. of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan. “Understanding Amyloid Oligomers and Finding Opportunities toward Combating Neurodegenerative Diseases”

11.        Oct. 17, 2016. The 23rd East Asia Joint Symposium, the 15th Cross-Strait Symposium on Biomedical Research and the 13th Symposium of the Frontiers of Biomedical Sciences, Taipei, Taiwan. “Full-length TDP-43 Forms Toxic Amyloid Oligomers in Frontotemporal Lobar Dementia-TDP Patients and Disturbs Amyloid-β Fibrillization”

12.        Oct. 7, 2016. Sunney Chan Symposium: Membrane Proteins: Biochemistry, Diseases, and Energy. Academia Sinica, Taipei, Taiwan. “Investigation of Pathogenic Proteins in Amyotrophic Lateral Sclerosis: TDP-43 and Dipeptide Repeats”

13.        Aug. 8, 2016. Gordon Conference: Neurobiology of Brain Disorder, Girona, Spain. “ The Discovery of Toxic TDP-43 Oligomers in TDP-43 Proteinopathies” (The only speaker from Asia)

14.     Jul. 23, 2016. 生技展BioTaiwan Exhibition, Taipei, Taiwan. “A novel antibody for neurodegenerative diseases”

15.     May 9, 2016. Dept. of Life Science, National Taiwan University, Taipei, Taiwan. “Understanding Amyloid Oligomers and Finding Opportunities toward Combating Neurodegenerative Diseases”

16.     Apr. 20, 2016. Taipei Medical University, Taipei, Taiwan. “Understanding Amyloid Oligomers and Finding Opportunities toward Combating Neurodegenerative Diseases”

17.     Dec. 17, 2015. 神經疾病產學交流研討會, Academia Sinica, Taipei, Taiwan. “Discovery of Amyloid Oligomers in Neurodegenerative Diseases”

18.     Nov. 27, 2015. Dept. of Life Science, National Normal University, Taipei, Taiwan. “Understanding amyloid oligomers and finding opportunities toward combating neurodegenerative diseases”

19.       Yun-Ru Chen. (Nov. 16, 2015). Protein Structure and Function-Joint Symposium between the Institute for Protein Research (Osaka University) and the Research School of Chemistry (Australian National University), Australia National University, Canberra, Australia. “Discovery of Amyloid Oligomers of TDP-43 in Neurodegenerative Diseases”

20.       Yun-Ru Chen. (Oct. 16, 2015). RIKEN-Academia Sinica Joint Conference on Chemical Biology, Academia Sinica, Taipei, Taiwan. “Understanding the Mechanism of Amyloid Formation: Stories of Amyloid-β and TDP-43”

21.       Yun-Ru Chen. (Jun. 14, 2015). Symposium of Taiwan Dementia Society, Taipei General Veteran Hospital, Taipei, Taiwan. “An emerging new player in frontotemporal lobar dementia, amyotrophic lateral sclerosis, and Alzheimer’s disease”

22.       Yun-Ru Chen. (Apr. 23, 2015). Dept. of Biochemical Science & Technology, National Taiwan University, Taipei, Taiwan. “Understanding structure and function of amyloid-β and TDP-43 oligomers and the opportunities toward combating neurodegenerative diseases”

23.       Yun-Ru Chen. (Mar. 21, 2015) The 12th International conference on Alzheimer’s and Parkinson’s diseases AD/PD 2015, Nice, France. “Full-length TDP-43 Forms Toxic Amyloid Oligomers that are Present in Frontotemporal Lobar Dementia-TDP Patients”

24.       Yun-Ru Chen. (Nov. 21, 2014) The 2nd Korea-Taiwan International Biophysics Workshop, Pusan, Korea. “Understanding the mechanism of amyloid Formation: Stories of Amyloid-β and TDP-43”

25.       Yun-Ru Chen. (Nov. 7, 2014) The 2nd Proteostasis & Disease Symposium, Wollongong, Australia. “Full-length TDP-43 Forms Toxic Amyloid Oligomers that are Present in Frontotemporal Lobar Dementia-TDP Patients”

26.       Yun-Ru Chen. (Oct. 9, 2014) National Tsing-Hua University Life Science Seminar Series, Taipei, Taiwan. “Understanding the mechanism of amyloid Formation: Stories of Amyloid-β and TDP-43.” 

27.       Yun-Ru Chen. (Oct. 6, 2014) Taipei General Veteran Hospital, Dept. of Neurology Seminar, Taipei, Taiwan. “Understanding Amyloid-β and TDP-43 Oligomers and the Opportunities toward Combating the Neurodegenerative Diseases.” 

28.       Yun-Ru Chen. (March 21, 2014) National Yang-Ming University Biomedical Seminar Series, Taipei, Taiwan. “Understanding the Formation and Function of Amyloid Oligomers in Neurodegenerative Diseases: Alzheimer’s Aβ, Parkinson’s alpha-synuclein, and FTLD-U/ALS’s TDP-43.” 

29.       Yun-Ru Chen. (May 15, 2013) National Taiwan University Hospital Seminar Series, Taipei, Taiwan. “Pathogenic Amyloid Proteins in Neurodegenerative Diseases.” 

30.       Yun-Ru Chen. (Jun. 2013) The 18th Biophysics Conference, Taipei, Taiwan. Young Investigator Award Lecture “The Role of Amyloid Oligomers in Amyloid Fibrillization: Amyloid-β in Alzheimer’s Disease and α-Synuclein in Parkinson’s Disease.”

31.       Yun-Ru Chen. (May. 2013) Frontier in Neurodegenerative Diseases and Beyond-From Basic to Translational, Taipei, Taiwan. “Distinct, Toxic Oligomer Formation during Co-existence of Alzheimer’s amyloid-b 40 and 42”

32.       Yun-Ru Chen. (Oct. 2012) Annual Meeting of Society of Neuroscience (SfN), New Orleans, Louisiana, USA. “Distinct, Toxic Oligomer Formation during Co-existence of Alzheimer’s amyloid b 40 and 42”

33.       Yun-Ru Chen. (Nov. 2011) Annual Meeting of Taiwan Society of Biochemistry and Molecular Biology, Taiwan. “Oligomerization and its Associated Toxicity in Amyloid-b in Alzheimer’s Disease”. 

34.       Yun-Ru Chen. (June 14, 2010) IPR Seminar: Cooperation in Protein Science between Asian and Pacific Countries, Osaka University, Osaka, Japan. “Folding Stability and Native Conformation of Amyloid-b Monomer are Important Determinants of the Nucleation Kinetics and Fibril Formation.”  

35.     Yun-Ru Chen. (Jan. 28-29, 2010) NCTS January Workshop on Critical Phenomena and Complex Systems, National Center for Theoretical Sciences and Inst. of Physics, Academia Sinica. “The Conformation Stability and Aggregation Mechanism of Amyloid-b”.

36.       Yun-Ru Chen. (May 19-21, 2010) 15th Joint Biophysics Conference, Taipei, Taiwan. “Folding Stability and Native Conformation of Amyloid-b Monomer are Important Determinants of the Nucleation Kinetics and Fibril Formation”.

37.       Yun-Ru Chen. (April, 2009) PepCon-2009, Seoul, Korea. “The conformational Stability and Aggregation Mechanisms of Amyloid b in Alzheimer Disease”. 

38.     Yun-Ru Chen. (Jun. 4-5, 2009) Frontier of Protein Aggregation and Neurodegenerative Diseases, Taipei, Academia Sinica. “The Conformation Stability and Aggregation Mechanism of Amyloid-b”.

39.     Yun-Ru Chen. (Jul. 27-28, 2009) NCTS July Workshop on Critical Phenomena and Complex Systems. “Conformational Stability of Amyloid-b Predominantly Determines the Nucleation Phase of Fibrillization”. 

40.     Yun-Ru Chen. (Oct. 12-13, 2007) NCTS July Workshop on Critical Phenomena and Complex Systems. “Equilibrium Folding and Aggregation of Wild Type and Familial Mutants of Amyloid-b in Alzheimer’s Disease”.

41.       Yun-Ru Chen. (August, 2007) Neuroscience Society of Taiwan, Hua Lien, Taiwan. “Equilibrium Folding and Aggregation Properties of Wild Type and Familial Mutants of Amyloid b in Alzheimer Disease”.

42.       Yun-Ru Chen. (Oct. 2006) IBC conferences: Structural and Biochemical Properties of Prions and Amyloids, Academia Sinica. “Distinct Equilibrium Folding Properties of Amyloid β peptide 40 and 42 prior aggregation: Stable Trimer or Tetramer Formation of Aβ42”. 

Serving as Conference Chairs:

1.   The 20th Biophysics Conference, R.O.C., May 7-10, 2016, Hsin-Chu,, Taiwan. Chairing at section: Frontiers of Protein Folding and Misfolding.

2.   The 19th Biophysics Conference, R.O.C., May 7-10, 2014, Tainan, Taiwan. Chairing at section : Protein Folding and Misfolding. 

3.   The 3rd APPA (Asian-Pacific Protein Association) Conference, May 6-9, 2011, Shanghai Univ., Shanghai, China. Co-chairing at section 3: Protein Folding, Structure, and Dynamics.

4.   PepCon-2009, Seoul, Korea. April 2-4, 2009. Co-chairing at section 3-3: Promising Protein Therapeutics for CNS Disorders/ Neurodegenerations.

Memberships:

•  Protein Society

•  ISTAART (International Society to Advance Alzheimer’s Research and Treatment)

•  Society of Neuroscience

•  APPA (Asian-Pacific Protein Association)

•  Taiwan Society for Biochemistry and Molecular Biology 台灣生物化學及分子生物學會

•  The Biophysics Society of Taiwan中華民國生物物理學會

•  The Neuroscience Society of Taiwan中華民國基礎神經科學會 

Council member and Conference Organizing Committee:

• Council member, The Biophysical Society of R.O.C. 中華民國生物物理學會理事(2016-present)

• Council member, The Taiwan Society for Biochemistry and Molecular Biology台灣生物化學及分子生物學會理事 (2015-present) 

• Council member, APPA (Asian-Pacific Protein Association) Representative of Taiwan. (2014.5-2017.7)

• Council member, APPA (Asian-Pacific Protein Association) Backup Representative of Taiwan. (2009-2014.5)

• Organizing Committee member, (Jun. 4-5, 2009) Frontier of Protein Aggregation and Neurodegenerative Diseases, Taipei, Academia Sinica 

Grant Review:

• Ministry of Science and Technology grant proposals, Taiwan 

• MRC grant proposals (Medical Research Council, UK)

• Univ. of California, Davis, Pilot project grant proposal (USA) 

Journal Referee:

• ACS Chemical Neuroscience 

• ACS Nano

• Biochemistry

•  BBA-Proteins and Proteomics

• JACS 

•  International Journal of Biological Macromolecules

• Journal of Inorganic Chemistry

•   Journal of Physical Chemistry

•   Neurochemistry International 

•   Small

•   Scientific Reports