Publications

PUBLICATIONS (*corresponding): 

1. Cheng YH*, Huang HP, Chen HH. Mucoadhesive phenylboronic acid-grafted carboxymethyl cellulose hydrogels containing glutathione for treatment of corneal epithelial cells exposed to benzalkonium chloride. Colloids and Surfaces B: Biointerfaces 2024; 238:113884 (SCI, IF: 5.8, Rank: 9/70, BIOPHYSICS)

2. Cheng YH*, Fung MP, Chen YQ, Chiu YC Development of mucoadhesive methacrylic anhydride-modified hydroxypropyl methylcellulose hydrogels for topical ocular drug delivery. Journal of Drug Delivery Science and Technology 2024; 93: 105450 (SCI, IF: 5.0, Rank: 60/277, PHARMACOLOGY & PHARMACY). 

3. Cheng YH, Chen HH, Liu YC, Yang KC. ROS-triggered drug release of puerarin from boronic ester modified nanoparticles to reduce oxidative damage in HUVECs. Journal of Drug Delivery Science and Technology 2023 (SCI, IF: 5.0, Rank: 60/277, PHARMACOLOGY & PHARMACY).

4. Chang YF, Cheng YH, Ko YC, Chiou SH, Liu CJ. Anti-apoptotic and autophagic effect: Using conditioned medium from human bone marrow mesenchymal stem cells to treat human trabecular meshwork cells. Regenerative Therapy 2023; 22:50-58. (SCI, IF: 4.3, Rank: 38/96, ENGINEERING, BIOMEDICAL)

5. Chen HH, Yu NY, Cheng YH*. Shear-thinning hydrogels containing reactive oxygen species-responsive nanoparticles for salvianolic acid B delivery to rescue oxidative damaged HUVECs. European Polymer Journal 2022; 164:110982 (SCI, IF: 6.0, Rank: 7/86, POLYMER SCIENCE).

6. Cheng YH*, Cheng SJ, Chen HH, Hsu WC. Development of injectable graphene oxide/ laponite/ gelatin hydrogel containing Wharton's jelly mesenchymal stem cells for treatment of oxidative stress-damaged cardiomyocytes. Colloids and surfaces B-biointerfaces 2022; 209: 112150 (SCI, IF: 5.8, Rank: 9/70, BIOPHYSICS).

7. Chang YF, Cheng YH, Ko YC, Chiou SH, Liu CJ. Development of topical chitosan/ β-glycerophosphate-based hydrogel loaded with levofloxacin in the treatment of keratitis: An ex-vivo study. Heliyon 2022; 8: e08697 (SCI, IF: 4.0, Rank: 23/73, MULTIDISCIPLINARY SCIENCES).

8. Cheng YH, Chang YF, Ko YC, Liu CJ. Development of a dual delivery of levofloxacin and prednisolone acetate via PLGA nanoparticles/ thermosensitive chitosan-based hydrogel for postoperative management: An in-vitro and ex-vivo study. International Journal of Biological Macromolecules 2021; 180: 365-374 (SCI, IF: 8.2, Rank: 5/86, POLYMER SCIENCE).

9. Tsai IL, Tsai CY, Kuo LL, Woung LC, Ku RY, Cheng YH*. PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage. Experimental Eye Research 2021; 206:108539 (SCI, IF: 3.4, Rank: 16/62, OPHTHALMOLOGY)

10. Wang CY, Hsiao CY, Tsai KL, Cheng YH*. Injectable thermosensitive chitosan‐based hydrogel containing ferulic acid for treating peripheral arterial disease. Journal of Tissue Engineering and Regenerative Medicine 2020; 14:1438-48. (SCI, IF: 3.3, Rank: 76/156, BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

11. Li JW, Cheng YH, Lee HT, Wang CC, Chiu CW, Suen MC. Synthesis and properties of castor oil-based polyurethane containing short fluorinated segment. Journal of Applied Polymer Science 2020; 137:49062. (SCI, IF: 3.0, Rank: 43/86, POLYMER SCIENCE)

12. Cheng YH, Chang YF, Ko YC, Liu CJ. Sustained release of levofloxacin from thermosensitive chitosan-based hydrogel for the treatment of postoperative endophthalmitis. Journal of Biomedical Materials Research: Part B 2020; 108:8-13  (SCI, IF: 3.4, Rank: 53/96, ENGINEERING, BIOMEDICAL)

13. Li JW, Cheng YH, Lee HT, Tsen WC, Chiu CW, Suen MC. Properties and degradation of castor oil-based fluoridated biopolyurethanes with different lengthsof fluorinated segments. RSC Advances 2019; 9:31133-49. (SCI, IF: 3.9, Rank: 74/178, CHEMISTRY, MULTIDISCIPLINARY)

14. Cheng YH, Ko YC, Chang YF, Huang SH, Liu CJ. Thermosensitive chitosan-gelatin-based hydrogel containing curcumin-loaded nanoparticles and latanoprost as a dual-drug delivery system for glaucoma treatment. Experimental Eye Research 2019; 179:178-87. (SCI, IF: 3.4, Rank: 16/62, OPHTHALMOLOGY)

15. Tsai KL, Hung CH, Chan SH, Hsieh PL, Ou HC, Cheng YH, Chu PM.  Chlorogenic acid protects against oxLDL-induced oxidative damage and mitochondrial dysfunction by modulating SIRT1 in endothelial cells. Molecular Nutrition & Food Research 2018; 62: 1700928 (SCI, IF: 5.2, Rank: 34/142, FOOD SCIENCE & TECHNOLOGY).

16. Chan SH, Hung CH, Shih JY, Chu PM, Cheng YH, Lin HC, Hsieh PL, Tsai KL. Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling. Redox Biology 2018; 14:116-125 (SCI, IF: 11.4, Rank: 15/315, BIOCHEMISTRY & MOLECULAR BIOLOGY).

17. Cheng YH, Chavez E, Tsai KL, Yang KC, Kuo WT, Yang YP, Chiou SH, Lin FH Effects of thermosensitive chitosan-gelatin based hydrogel containing glutathione on Cisd2-deficient chondrocytes under oxidative stress. Carbohydrate Polymers 2017; 173:17-27. (SCI, IF: 11.2, Rank: 1/93, POLYMER SCIENCE)

18. Chan SH, Hung CH, Shih JY, Chu PM, Cheng YH, Lin HC, Tsai KL. SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease. Redox Biology 2017; 13:301-309 (SCI, IF: 11.4, Rank: 15/315, BIOCHEMISTRY & MOLECULAR BIOLOGY)

19. Cheng YH, Lin FH, Wang CY, Hsiao CY, Chen HC, Kuo HY, Tsai TF, Chiou SH. Recovery of oxidative stress-induced damage in cisd2-deficient cardiomyocytes by sustained release of ferulic acid from injectable hydrogel. Biomaterials. 2016; 103:207-18. (SCI, IF: 14.0, Rank: 4/96, ENGINEERING, BIOMEDICAL)

20. Cheng YH, Tsai TH, Jhan YY, Chiu AW, Tsai KL, CS Chien, Chiou SH, Liu CJ. Thermosensitive chitosan-based hydrogel as a topical ocular drug delivery system of latanoprost for glaucoma treatment. Carbohydrate Polymers 2016; 144:390-9. (SCI, IF: 11.2, Rank: 1/93, POLYMER SCIENCE)

21. Tsai CY, Woung LC, Yen JC, Tseng PC, Chiou SH, Sung YJ, Liu KT, Cheng YH*. Thermosensitive chitosan-based hydrogels for sustained release of ferulic acid on corneal wound healing. Carbohydrate Polymers 2016; 135:308-15. (SCI, IF: 11.2, Rank: 1/93, POLYMER SCIENCE)

22. Tsai KL, Chang YL, Huang PH, Cheng YH, Liu DH, Chen HY, Kao CL. Ginkgo biloba extract inhibits oxidized low-density lipoprotein (oxLDL)-induced matrix metalloproteinase activation by the modulation of the lectin-like oxLDL receptor 1-regulated signaling pathway in human umbilical vein endothelial cells. Journal of Vascular Surgery 2016; 63:204-15 (SCI, IF: 4.3, Rank: 27/212, SURGERY)

23. Chan SH, Chu PM, Kao CL, Cheng YH, Hung CH, Tsai KL. Oleic acid activates MMPs up-regulation through SIRT1/PPAR-γ inhibition: a probable linkage between obesity and coronary arterial disease. Journal of Biochemistry 2016; 160:217-225 (SCI, IF: 2.7, Rank: 214/285, BIOCHEMISTRY & MOLECULAR BIOLOGY)

24. Kuo WT, Huang JY, Chen MH, Chen CY, Shyong YJ, Yen KC, Sun YJ, Ke CJ, Cheng YH, Lin FH. Development of gelatin nanoparticles conjugated with phytohemagglutinin erythroagglutinating loaded with gemcitabine for inducing apoptosis in non-small cell lung cancer cells. Journal of Materials Chemistry B 2016; 4:2444-54 (SCI, IF: 7.0 Rank: 10/45, MATERIALS SCIENCE, BIOMATERIALS)

25. Tsai IL, Hsu CC, Hung KH, Chang CW, Cheng YH*. Mini-review: Applications of biomaterials in corneal wound healing. Journal of the Chinese Medical Association 2015; 78:212-17. (SCI, IF: 3.0, Rank: 75/167, MEDICINE, GENERAL & INTERNAL)

26. Cheng YH, Hung KH, Tsai TH, Lee CJ, Ku RY, Chiu AW, Chiou SH, Liu CJ. Sustained delivery of latanoprost by thermosensitive chitosan-gelatin-based hydrogel for controlling ocular hypertension. Acta Biomaterialia 2014; 10: 4360-66 (SCI, IF: 9.7, Rank: 9/96, ENGINEERING, BIOMEDICAL)

27. Tsai KL, Huang PH, Kao CL, Leu SB, Cheng YH, Liao YW, et al. Aspirin attenuates Vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis. Biochemical Pharmacology 2014; 88:189-200. (SCI, IF: 5.8, Rank: 40/277, PHARMACOLOGY & PHARMACY)

28. Chang YC, Chang WC, Hung KH, Yang DM, Cheng YH, Liao YW, Woung LC, Tsai CY, Hsu CC, Lin TC, Liu JH, Chiou SH, Peng CH, Chen SJ. The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress. Frontiers in Aging Neuroscience 2014; 6:191. (SCI, IF: 4.8, Rank: 80/272, NEUROSCIENCES)

29. Cheng YH, Yang SH, Liu CC, Gefen A, Lin FH. Thermosensitive hydrogel made of ferulic acid-gelatin and chitosan glycerophosphate. Carbohydrate Polymers 2013; 92:1512-9. (SCI, IF: 11.2, Rank: 1/93, POLYMER SCIENCE)

30. Cheng YH, Yang SH, Lin FH. Thermosensitive chitosan-gelatin-glycerol phosphate hydrogel as a controlled release system of ferulic acid for nucleus pulposus regeneration. Biomaterials. 2011; 32:6953-61. (SCI, IF: 14.0, Rank: 4/96, ENGINEERING, BIOMEDICAL)

31. Cheng YH, Yang SH, Yang KC, Chen MP, Lin FH. The effects of ferulic acid on nucleus pulposus cells under hydrogen peroxide-induced oxidative stress. Process Biochemistry 2011; 46:1670-7. (SCI, IF:4.4, Rank: 42/140, ENGINEERING, CHEMICAL)

32. Cheng YH, Yang SH, Su WY, Chen YC, Yang KC, Cheng WT, Wu SC, Lin FH. Thermosensitive chitosan-gelatin-glycerol phosphate hydrogels as a cell carrier for nucleus pulposus regeneration: an in-vitro study. Tissue Engineering Part A 2010; 16:695-703. (SCI, IF: 4.1, Rank: 41/96, ENGINEERING, BIOMEDICAL)

33. Chen MP, Yang SH, Chou CH, Yang KC, Wu CC, Cheng YH, Lin FH. The chondroprotective effects of ferulic acid on hydrogen peroxide-stimulated chondrocytes: inhibition of hydrogen peroxide-induced pro-inflammatory cytokines and metalloproteinase gene expression at the mRNA level. Inflammation Research 2010; 59:587-95. (SCI, IF: 6.7, Rank: 42/161, IMMUNOLOGY)

34. Yang KC, Wu CC, Cheng YH, Kuo TF, Lin FH. Chitosan/gelatin hydrogel prolonged the function of insulinoma/agarose microspheres in vivo during xenogenic transplantation. Transplantation Proceedings 2008; 40:3623-6. (SCI, IF: 0.9, Rank: 186/212, SURGERY)

35. Yang KC, Wu CC, Lin FH, Qi Z, Kuo TF, Cheng YH, Chen MP, Sumi S. Chitosan/gelatin hydrogel as immunoisolative matrix for injectable bioartificial pancreas. Xenotransplantation 2008; 15:407-16. (SCI, IF: 3.9, Rank: 71/189, MEDICINE, RESEARCH & EXPERIMENTAL)

PATENT: 

• Chiou SH, Liu CJ, Cheng YH. A sustained releasing pharmaceutical composition (United States Patent: 9,314,446)