Publications

Research Articles  

From current position

1. Liu, Y.-H., Chuang, C.-H., Lee, Y.-Z., Lee, E.-T., Lo, C.-L., Wu, C.-Y., Huang, L.-K., Bikfalvi, A., Sue, S.-C.* (2022) The structural properties of CXCL4L1 and its recognition of the CXCR3 N-terminus. Biochemistry 62, 722-734. *Corresponding Author

2. Wu, C.-L., Chih, Y.-H., Hsieh, H.-Y., Peng, K.-L., Lee, Y.-Z., Yip, B.-S., Sue, S.-C.*, Cheng, J.-W.* (2022) High Level Expression and Purification of Cecropin-like Antimicrobial Peptides in Escherichia coli. Biomedicines 10,1351. *Corresponding Author

3. Tang, N., Lu, C.-Y., Sue, S.-C, Chen, T.-H., Jan, J.-T., Huang, M.-H., Huang, C.-H., Chen, C.-C., Chiang, B.-L., Huang, L.-M., Wu, S.-C.* (2020) Type IIb Heat Labile Enterotoxin B Subunit as a Mucosal Adjuvant to Enhance Protective Immunity against H5N1 Avian Influenza Viruses. Vaccines, 8, 710.

4. Lan, Y.-J., Yeh, P.-S., Kao, T.-Y., Lo, Y.-C., Sue, S.-C., Chen, Y.-W., Hwang, D.-W., Chiang, Y.-W.* (2020) Anti-apoptotic BCL-2 regulation by changes in dynamics of its long unstructured loop. Commun Biol., 3, 668. 

5. Li, J.-Y., Chen, Y.-C., Lee, Y.-Z., Huang, C.-H., Sue, S.-C*. (2020) N-terminal backbone pairing shifts in CCL5-12AAA14 dimer interface: Structural significance of the FAY sequence. International Journal of Molecular Sciences. 21, E1689. *Corresponding Author

6. Chen, Y. C., Chen, S. P., Li, J. Y., Chen, P. C., Lee, Y. Z., Li, K. M., Li, K.-M., Zarivach, R., Sun, Y.-J., Sue, S.-C*. (2020). Integrative model to coordinate the oligomerization and aggregation mechanisms of CCL5. Journal of Molecular Biology. 432, 1143-1157. *Corresponding Author

7. Chen, S.-H., Chao, A., Tsai, C.-L., Sue, S.-C., Lin, C.-Y., Lee, Y.-Z., Hung, Y.-L., Chao, A.-S., Cheng, A.-J., Wang, H.-S., Wang, T.-H. (2018) Utilization of HEPES for Enhancing Protein Transfection into Mammalian Cells. Mol Ther Methods Clin Dev.13, 99-111.

8. Hila Nudelman, Yi-Zong Lee, Yi-Lin Hung, Sofiya Kolusheva, Alexander Upcher, Yi-chen Chen, Jih-Ying Chen, Shih-Che Sue*, and Raz Zarivach*. (2018) Understanding the biomineralization role of magnetite-interacting components (MICs) from magnetotactic bacteria. Front Microbiol. 9:2480 *Corresponding Author

9. Chen, Y.-C., Li, K.-M., Zarivach, R., Sun, Y.-J., Sue, S.-C*. (2018) Human CCL5 trimer: expression, purification and initial crystallographic studies. Acta Cryst. F74, 82-85. *Corresponding Author

10. Boye, K., Pujol, N., I, D. A., Chen, Y. P., Daubon, T., Lee, Y. Z., Dedieu. S., Constantin, M., Bello, L., Rossi, M., Bjerkvig, R., Sue, S. C., Bikfalvi, A., and Billottet, C. (2017) The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors. Nature communications 8, 1571.

11. Chen, Y.-P., Wu, H.-L., Kevin Boye, Pan, C.-Y., Chen, Y.-C., Nadege Pujol, Lin, C.-W., Chiu, L.-Y., Clotilde Billottet, Isabel D. Alves, Andreas Bikfalvi, Sue, S.-C.* (2017) Oligomerization state of CXCL4 chemokines regulates G protein-couple receptor activation. ACS Chem Biol. 12, 2767-2778. *Corresponding Author

12. Hung, L.-C., Chiang, I.-J., Chen, C.-J., Lu, J.-Y., Hsieh, Y.-F., Kuo, P.-H., Hung, Y.-L., Wang, L.-H, Chang, M. D.*, Sue, S.-C.* (2017) Heparin-Promoted Cellular Uptake of The Cell-Penetrating Peptide GBPECP Depends On A Single Tryptophan. ACS Chem Biol. 12(2), 298-406. *Corresponding Author

13. Hung, Y.-L., Chiang, I.-J., Lee, Y.-Z., Wen, C.-K., Sue, S.-C.* (2016). NMR Study Reveals the Receiver Domain of Arabidopsis ETHYLENE RESPONSE1 Ethylene Receptor as an Atypical Type Response Regulator. PloS ONE, 11, e0160598. *Corresponding Author

14. Chen, W.-T., Huang, W.-Y., Chen, T., Salawu, E.-O., Wang, D., Lee, Y.-Z., Chang, Y.-Y., Yang, L.-W., Sue, S.-C., Wang, X., Yin, H.-S. (2016) Structure and function of chicken interleukin-1 beta mutants: uncoupling of receptor binding and in vivo biological activity. Sci Rep., 6, 27729.

15. Tsai, C.-L., Chao, A., Jung, S.-M., Tsai, C.-N., Lin, C.-Y., Chen, S.-H., Sue, S.-C., Wang, T.-H., Wang, H.-S., Lai, C.-H. (2016) Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells. Oncotarget, 7, 50548-50563.

16. Quemener, C., Baud, J., Boye, K., Dubrac, A., Billottet, C., Soulet, F., Darlot, F., Dumartin, L., Sire, M., Grepin, R., Daubon, T., Rayne, F., Wodrich, H., Couvelard, A., Pineau, R., Schilling, M., Castronovo, V., Sue, S.-C., Clarke, K., Lomri, A., Khatib, A.M., Hagedorn, M., Prats, H., Bikfalvi, A. (2016) Dual roles for CXCL4 chemokines and CXCR3 in angiogenesis and invasion of pancreatic cancer. Cancer Res., 76, 6507-6519.

17. Hung, Y.-L., Lee, H.-J., Jiang, I., Lin, S.-C., Lo, W.-C., Lin, Y.-J. and Sue, S.-C.* (2015) The First Residue of the PWWP Motif Modulates HATH Domain Binding, Stability, and Protein-Protein Interaction. Biochemistry, 54, 4063-4074 *Corresponding Author

18. Hung, Y.-L., Lin, Y.-J. and Sue, S.-C.* (2015) 13C, 15N and 1H resonance assignments of receiver domain of ethylene receptor ETR1. Bimolecular NMR Assignments, 9, 119-122 *Corresponding Author

19. Chiu, L.-Y., Hung, K.-W., Tjong, S.-C., Chiang, Y.-W. and Sue, S.-C.* (2014) NMR characterization of the electrostatic interaction of the basic residues in HDGF and FGF2 during heparin binding. Biochim. Biophys. Acta-Proteins and Proteomics, 1844, 1851-1859. *Corresponding Author

20. Chen, Y.-C., Cheng, C.-S., Tjong, S.-C., Yin, H.-S.* and Sue, S.-C.* (2014) Case Study of Hydrogen bonding in a hydrophobic Cavity. J. Phys. Chem. B., 118, 14602-14611. *Corresponding Author

21.  Lee, Y.-R., Lee, Y.-T., Lin, Y.-J., Chen, Y.-J.* and Sue, S.-C.* (2014) A streamlined method for preparing split intein for NMR study. Protein Expression and Purification, 99, 106-112. *Corresponding Author

22. Lin, H.-H., Lee, H.-C., Li, X.-F., Tsai, M.-J., Hsiao, H.-J., Peng, J.-G., Sue, S.-C., Qin, C.-F., Wu, S.-C. (2014) Dengue type four viruses with E-Glu345Lys adaptive mutation from MRC-5 cells induce low viremia but elicit potent neutralizing antibodies in rhesus monkeys. PloS One, 9, e100130. 

23. Platonova, N., Miquel, G., Chiu, L.-Y., Taouji, S., Moroni, E., Colombo, G., Chevet, E., Sue, S.-C., Bikfalvi, A. (2014) Dimerization Capacities of FGF2 Purified with or without Heparin-Affinity Chromatography. PloS One, 9, e110055. 

24. Lin, Y.-J., Lai, C.-C., Lai, C.-H., Sue, S.-C., Lin, C.-W., Hung, C.-H., Lin, T.-H., Hsu, W.-Y., Huang, S.-M., Hung, Y.-L., Tien, N., Liu, X., Chen, C.-L., Tsai, F.-J. (2013) Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide. Eur J Med Chem., 62, 206-213.

25. Kuo, J.-H., Chen, Y.-P., Liu, J.-S., Durac, A., Quemener, C., Prats, H., Bikfalvi, A., Wu, W.-g.* and Sue, S.-C.* (2013) Alternative C-Terminal Helix Orientation Alters Chemokine Function: Structure of the Anti-angiogenic Chemokine, CXCL4L1. J. Biol. Chem., 288, 13522-13533. *Corresponding Author

26. Yu, H.-Y., Yip, B.-S., Tu, C.-H., Chen, H.-L., Chu, H.-L., Chih, Y.-H., Cheng, H.-T., Huang, K.-C., Sue, S.-C.* and J.-W. Cheng* (2013) Correlations between Membrane Immersion Depth, Orientation, and Salt-Resistance of Tryptophan-rich Antimicrobial Peptides. Biochim. Biophys. Acta-Biomembranes, 1828, 2720-2728. *Corresponding Author

27. Cervantes, C.F., Handley, L.D., Sue, S.-C., Dyson, H.J., Komives, E.A. (2013) Longrange effects and functional consequences of stabilizing mutations in the ankyrin repeat domain of IκBα.. J. Mol. Biol., 425, 902-913.

28. Chen, F.-F., Lin, W.-H., Lin, S.-C., Kuo, J.-H., Chu, H.-Y., Huang, W.-C., Chuang, Y.-J., Lee, S.-C. and Sue, S.-C.* (2012) Significance of heparin binding to basic residues in homologous to amino terminus domain of hepatoma-derived growth factor and related proteins. Glycobiology, 22, 649-661. *Corresponding Author

29. Lee, Y.-T., Su, T.-H., Lo W.-C., Lyu, P.-C.* and Sue, S.-C.* (2012) Circular Permutation Prediction Reveals a Viable Backbone Disconnection for Split Proteins: An Approach in Identifying a New Functional Split Intein. PloS ONE, 7, e43820. *Corresponding Author

30. Vila, J. A., Sue, S.-C., Fraser, J. S., Scheraga, H. A., Dyson, H. J. (2012) CheShift-2 distinguishes the correct version of a local inconsistency between two X-ray crystal structures. J. Biomol. NMR, 54, 193-198.

31. Wang, C.H., Davamani F., Sue, S.-C., Lee, S.C., Wu, P.L., Tang, F.M., Shih, C., Huang, T.-h., and Wu, W.-g. (2011) Cell surface heparan sulfates mediate internalization of the PWWP/HATH domain of HDGF via macropinocytosis to fine-tune cell signalling processes involved in fibroblast cell migration. Biochem. J., 433, 127-138.

32. Cervantes, C.F., Bergqvist, S., Kjaergaard, M., Kroon, G., Sue, S.-C., Dyson, H.J. and Komives, E.A. (2011) The RelA nuclear localization signal folds upon binding to IκBα. J. Mol. Biol., 405, 754-764.

33. Sue, S.-C., Alverdi, V., Komives, E.A. and Dyson, H.J. (2011) Detection of a ternary complex of NF-kB and IkBa with DNA provides insights into how IkappaBalpha removes NF-kappaB from transcription sites. Proc. Natl. Acad. Sci., 108, 1367-1372. 

34. Sue, S.-C. and Dyson, H. J. (2009) Interaction of the IkBa C-terminal PEST sequence with NF-kB: insights into the inhibition of NF-kB DNA binding by IkBa. J. Mol. Biol., 388, 824-838. 

35. Cervantes, C.F., Markwick, P.R., Sue S.-C, McCammon, J.A., Dyson, H.J., Komives, E.A. (2009) Dynamics of the folded ankyrin repeats of IB revealed by NMR. Biochemistry, 33, 8023-8031.

Before 2009 

1. Sue, S.-C., Cervantes C. F., Komives E. A., and Dyson, H. J. (2008) Transfer of flexibility between ankyrin repeats in IkBa upon formation of the NF-kB complex. J. Mol. Biol., 380, 917-931. 

2. Sue, S.-C., Lee, W.-T., Tien, S.-C., Lee, S.-C., Yu, J.-G., Wu, W.-g., and Huang T.-h. (2007) Observation of domain swapping as a mechanism for enhancing the heparin binding affinity of the HATH domain of human hepatoma-derived growth factor. J. Mol. Biol., 367, 456-472.

3. Chen, C.-Y., Chang, C.-K., Chang, Y.-W., Sue, S.-C., Bai, H.-I., Riang, L., Hsiao, C.-D., and Huang, T.-h. (2007) Structure of the SARS coronavirus nucleocapsid protein RNA-binding dimerization domain suggests a mechanism for helical packaging of viral RNA. J. Mol. Biol., 368, 1075-1086.

4. Chang, C.-K.#, Sue, S.-C. #, Yu, T.-h., Hsieh, C.-M., Tsai, C.-K., Chiang Y.-C., Lee, S.-j., Hsiao, H.-h., Wu, W.-J., Chang, W.-L., Lin, C.-H., and Huang, T.-h. (2006) Molecular organization of SARS coronavirus nucleocapsid protein. J. Biomedical Sci., 13, 59-72. #Contribution equally

5. Sue, S.-C., Hsiao, H.-h., Chung, B. C.-P., Cheng, Y.-H., Hsueh, K.-L., Chen, C.-M., Ho, C.-H., and Huang, T.-h. (2006) Solution structure of Arabidopsis thaliana telomeric repeat-binding domain: a new fold with an additional C-terminal helix. J. Mol. Biol., 356, 72-85.   

6. Sue, S.-C., Chang, C.-F., Huang, Y.-T., Chou, C.-Y., and Huang, T.-h. (2005) Challenges in NMR-based structural genomics. Physica A, 350, 12-27.

7. Chang, C.-K.#, Sue, S.-C. #, Yu, T.-h., Hsieh, C.-M., Tsai, C.-K., Chiang Y.-C., Lee, S.-j., Hsiao, H.-h., Wu, W.-J., Chang, C.-F., and Huang, T.-h. The dimer interface of the SARS coronavirus nucleocapsid protein adapts a porcine respiratory and reproductive syndrome virus-like structure. (2005) FEBS Lett., 579, 5663-5668. #Contribution equally

8. Sue, S.-C., Chen, J.-Y., and Huang, T.-h. (2004) Sequence specific 1H, 13C and 15N resonance assignments of the hath-domain of hepatoma-derived growth factor. J. Biomol. NMR, 29, 95-6. 

9. Sue, S.-C., Chen, J.-Y., Lee S.-C., Wu, W.-g., and Huang, T.-h. (2004) Solution structure and heparin interaction of human hepatoma-derived growth factor. J. Mol. Biol., 343, 1365-1377.

10. Huang, W.-N., Sue, S.-C., Wang, D.-S., Wu, P.-L., and Wu. W.-g. (2003) Peripheral binding mode and penetration depth of cobra cardiotoxin on phospholipid membranes as studied by a combined FTIR and computer simulation approach. Biochemistry, 42, 7457-7466. 

11. Sue, S.-C., Chien, K.-Y., Huang, W.-N., Joseph K., A., Chen, K.-M. and Wu, W.-g. (2002) Heparin binding stabilizes the membrane bound form of cobra cardiotoxin. J. Biol. Chem., 277, 2666-2673. 

12. Sue, S.-C., Jarrell, H., Brisson, J.-R., and Wu, W.-g. (2001) Dynamic charaterization of the water binding loop in the P-type cardiotoxin: implication of the role of bound water molecule. Biochemistry, 40, 12782-12794.

13. Sue, S.-C., Brisson, J.-R., Chang, W., Huang, W.-N., Lee, S.-C., Jarrell, H., and Wu, W.-g. (2001) Structures of heparin-derived disaccharide bound to cobra cardiotoxins: context dependent conformational change of heparin upon binding to the rigid core of the three fingered toxin. Biochemistry, 40, 10436-10446.

14. Lin, Y.-H., Lee, S.-C., Chang, P. Y., Rajan, P. K., Sue S.-C., and Wu, W.-g. (1999) Heparin binding to cobra basic phospholipase A2 depends on heparin chain length and amino acid specificity. FEBS letters, 453, 395-399.

15. Sue, S.-C., Rajan, P. K., Chen, T.-S., Hsieh, C.-H. and Wu, W.-g. (1997) Action of Taiwan cobra cardiotoxin on membranes: binding modes of a b-sheet polypeptide with phosphatidylcholine bilayers. Biochemistry, 36, 9826-9836. 

16. Hsieh, C.-H., Sue, S.-C., Lyu, P.-C., and Wu, W.-g. (1997) Membrane packing geometry of diphytanoylphosphatidylcholine is highly sensitive to hydration: phospholipid polymorphism induced by molecular rearrangement in the headgroup region. Biophys. J., 73, 870-877. 

Book Chapters

From current position

1. Lee, Y. Z., & Sue, S. C.* (2019). Salt-sensitive intein for large-scale polypeptide production. Methods in enzymology, 621, 111-130. 

2. Lee, Y.-Z., Lo, W.-C.*, and Sue, S.-C.* (2017) Chapter 17: Computational Prediction of New Intein Split Sites, Split inteins, Mootz H. D. (ed), Meth. Mol. Biol. – Springer, 1495, 259-268.

Before 2009 

1. Dyson, H. J., Sue, S.-C. and Wright, P. E. (2009) Chapter 6: Functional unfolded proteins: how, when, where, and why? Water and Biomolecules,  Kuwajima K., Goto, Y., Hirata F., Kataoka, M, and Terazima, M. (eds), Springer-verlag Berlin Heidelberg

2. Brisson, J.-R., Sue, S.-C., Wu, W.-g., McManus, G., Nghia, P. T., and Uhrín D. (2003) Chapter 4: NMR of carbohydrates: 1D Homonuclear Selective Methods, NMR Spectroscopy of Glyco-Conjugates, Jiménez-Barbero J., and Peters, T. (eds), WILEY-VCH Verlag GmbH, Weinheim.