We are dedicated to transforming cutting-edge nanobiotechnology into intuitive and precise medical diagnostic tools. Our research focuses on the development and application of Functional Nucleic Acids (FNAs), a highly promising molecular analysis platform that offers distinct advantages over traditional antibody-based immunoassays.
Simple Colorimetric Readout: Our platform is designed for maximum user accessibility. Results can be determined by observing a distinct red-to-blue color transition within a single reaction tube. By integrating smartphone-based imaging, the colorimetric data can be instantly digitized to quantify target concentrations with high precision. This intuitive, rapid, and digital workflow significantly enhances the feasibility and practicality of point-of-care testing (POCT).
Complex Molecular Mechanisms: Beneath this intuitive readout lies a foundation of precisely engineered molecular science. We employ aptamer engineering to achieve highly specific molecular recognition, combined with duplex-specific nuclease (DSN)-mediated signal amplification and enzyme-like catalysis to enhance the detection limits for trace disease biomarkers. Furthermore, these platforms are rigorously validated using fluorescence, surface plasmon resonance (SPR), and electrophoresis to ensure the stability and precision of the underlying molecular dynamics.