Research Projects / 研究主題
A. The DNA repair project: 天然藥物調控DNA修補之分子機轉與應用
Targeting DNA repair pathways to potentiate the efficacy of DNA damage-based therapies, such as chemotherapy and radiotherapy, has emerged as a promising strategy in cancer treatment. Moreover, inhibition of DNA repair offers a means to selectively eliminate tumor cells while minimizing adverse side effects. By employing a single-strand annealing (SSA) system, our laboratory screens natural compounds that suppress DNA repair and investigates their underlying molecular pharmacological mechanisms, thereby providing insights that may guide the rational design and development of novel agents for combination therapy with radiotherapy and chemotherapy.
標靶DNA修補路徑進而提升DNA損傷療法如化學治療及放射治療療效，已成為熱門的癌症治療策略。除此之外，藉由抑制DNA修補可更專一的毒殺腫瘤細胞並減少治療副作用，本實驗室利用損傷定位系統篩選抑制DNA之天然藥物並研究其分子藥理機轉，可助於設計和發展合併放射治療和化學治療的新藥物。
B. Aging and aging-associated diseases: 延長壽命/抗肥胖藥物之篩選及機轉研究
Systems for screening lifespan-extending compounds remain limited. Our laboratory has established a novel high-throughput screening platform to identify drugs with lifespan-promoting effects and to investigate their molecular mechanisms. In light of the rapidly aging global population, such health-promoting agents may serve not only in the prevention and treatment of aging-associated disorders but also in substantially reducing future healthcare expenditures for the elderly, ultimately contributing to the goal of achieving healthy aging.
篩選增加壽命藥物的系統極少，本實驗室利用一套新穎的篩選系統大量篩選具有延長壽命功效的藥物，並研究其分子機制。針對人口老化日趨嚴重的社會現象，此類型健康食品可用於預防及治療老化相關的病狀，更可望大量減少未來老年人口的醫療資源支出，真正達到健康老化的最終目的。