Publications

Publications

2025

• Neuroprotective Efficacy of Astragalus mongholicus in Ischemic stroke: Antioxidant and Anti-inflammatory mechanisms

• Astragalus mongholicus and Scutellaria baicalensis Extracts Mixture Target Pyroptosis in Ischemic Stroke via the NLRP3 Pathway

• Regulatory Mechanisms and Therapeutic Implications of Lysosomal Dysfunction in Alzheimer's Disease

2024

• Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review

• Synthesis of Highly Porous Graphene Oxide–PEI Foams for Enhanced Sound Absorption in High-Frequency Regime

• GPR40 agonist ameliorates neurodegeneration and motor impairment by regulating NLRP3 inflammasome in Parkinson’s disease animal models

• Potential Exosome Biomarkers for Parkinson’s Disease Diagnosis: A Systematic Review and Meta-Analysis

2023

• H.W SEO, T.Y HA, G.KO , A.R Jang, JW. Choi, D.H Lee, K.A Chang. Scutellaria baicalensis Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice. Cells 2023, 12(17), 2133

• Y.K Kim, J.H KIM, S.W Kang, K.A Chang. Depressive-like Behaviors Induced by mGluR5 Reduction in 6xTg in Mouse Model of Alzheimer’s Disease. IJMS 2023, 24(16), 13010 

• G. KO, J.H Kim, Y.J Jeon, D.H Lee, H.M Baek, K.A Chang. Salvia miltiorrhiza Alleviates Memory Deficit Induced by Ischemic Brain Injury in a Transient MCAO Mouse Model by Inhibiting Ferroptosis. Antioxidants 2023, 12(4), 785 

• Mammalian Models in Alzheimer’s Research: An Update

• GFAP as a Potential Biomarker for Alzheimer's Disease: A Systematic Review and Meta-Analysis

• Neurodegenerative Changes in the Brains of the 5xFAD Alzheimer's Disease Model Mice Investigated by High-Field and High-Resolution Magnetic Resonance Imaging and Multi-Nuclei Magnetic Resonance Spectroscopy

• Signal-to-Noise Ratio Enhancement of Single-Voxel In Vivo P-31 and H-1 Magnetic Resonance Spectroscopy in Mice Brain Data Using Low-Rank Denoising

• Metabotropic Glutamate Receptor 5 in Amygdala Target Neurons Regulates Susceptibility to Chronic Social Stress

• Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer's disease

• Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review

2022

• Effect of cx-DHED on Abnormal Glucose Transporter Expression Induced by AD Pathologies in the 5xFAD Mouse Model

• Non-Invasive Nasal Discharge Fluid and Other Body Fluid Biomarkers in Alzheimer's Disease

• MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 x Tg Alzheimer's Disease Model Mice

• The potential anti-amyloidogenic candidate, SPA1413, for Alzheimer's disease

• miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3 gamma in early stage of 5xFAD mouse model of Alzheimer's disease

• In Vivo Cerebral Translocator Protein (TSPO) Binding and Its Relationship with Blood Adiponectin Levels in Treatment-Naive Young Adults with Major Depression: A [C-11]PK11195 PET Study

• Potential Biomarkers for Post-Stroke Cognitive Impairment: A Systematic Review and Meta-Analysis

2021

• RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer’s disease

• Long-Term Treatment of Cuban Policosanol Attenuates Abnormal Oxidative Stress and Inflammatory Response via Amyloid Plaques Reduction in 5xFAD Mice

• Sex Difference in Peripheral Inflammatory Biomarkers in Drug-Naive Patients with Major Depression in Young Adulthood

• Brain-Derived Exosomal Proteins as Effective Biomarkers for Alzheimer's Disease: A Systematic Review and Meta-Analysis

• Potential of N-trans feruloyl tyramine from Lycium barbarum fruit extract on neurogenesis and neurotrophins; targeting TrkA/ERK/CREB signaling pathway

• Therapeutic Potential of Magnetic Nanoparticle-Based Human Adipose-Derived Stem Cells in a Mouse Model of Parkinson's Disease

• Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice

• Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice

• Spatial memory deficiency early in 6xTg Alzheimer’s disease mouse model

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2020

• Therapeutic Potential of Repeated Intravenous Transplantation of Human Adipose-Derived Stem Cells in Subchronic MPTP-Induced Parkinson's Disease Mouse Model

• Serum tau proteins as potential biomarkers for the assessment of alzheimer’s disease progression

• Longitudinal profiling of oligomeric Aβ in human nasal discharge reflecting cognitive decline in probable Alzheimer’s disease

• Therapeutic Effects of Human Amniotic Epithelial Stem Cells in a Transgenic Mouse Model of Alzheimer's Disease

• Structural Modification of Indolinone-Diene Analogues as Alpha-Synuclein Ligands and Its Structure-Activity Relationship Analysis

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2019

• Synthesis and evaluation of novel potent TSPO PET ligands with 2-phenylpyrazolo [1,5-a]pyrimidin-3-yl acetamide

• The Protective Effects of PSM-04 Against Beta Amyloid-Induced Neurotoxicity in Primary Cortical Neurons and an Animal Model of Alzheimer's Disease

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2018

• Novel potential pyrazolopyrimidine based translocator protein ligands for the evaluation of neuroinflammation with PET

• Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model

• Blood-based immunoassay of tau proteins for early diagnosis of Alzheimer's disease using surface plasmon resonance fiber sensors

• Distinct amyloid precursor protein processing machineries of the olfactory system

2017

• Differential spatial expression of peripheral olfactory neuron-derived BACE1 induces olfactory impairment by region-specific accumulation of beta-amyloid oligomer

• Human adipose-derived stem cells ameliorate repetitive behavior, social deficit and anxiety in a VPA-induced autism mouse model

2016

• Impedimetric Tumor Necrosis Factor-alpha Sensor Based on a Reduced Graphene Oxide Nanoparticle-Modified Electrode Array

• S100A9 Exacerbates the A beta 1-42-mediated Innate Immunity in Human THP-1 Monocytes

• Dehydroevodiamine center dot HCl Protects Against Memory Impairment and Cerebral Amyloid-beta Production in Tg2576 Mice by Acting as a beta-Secretase Inhibitor

• Plasma soluble neuregulin-1 as a diagnostic biomarker for Alzheimer's disease

• Sensitivity enhancement of capacitive tumor necrosis factor-alpha detection by deposition of nanoparticles on interdigitated electrode

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2015

• 알츠하이머질병 모델동물인 Tg2576 마우스를 이용한 미나리 알코올추출물의 기억력 개선 효능

• Therapeutic potentials of human adipose-derived stem cells on the mouse model of Parkinson's disease

• Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau

• Neural stem cell transplantation at critical period improves learning and memory through restoring synaptic impairment in Alzheimer's disease mouse model

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2014

• Therapeutic Potential of Human Adipose-Derived Stem Cells in Neurological Disorders

• In vivo imaging of human adipose-derived stem cells in Alzheimer's disease animal model

• Dehydroevodiamine center dot HCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats

• S100A9 Knockout Decreases the Memory Impairment and Neuropathology in Crossbreed Mice of Tg2576 and S100A9 Knockout Mice Model

• The Therapeutic Effects of Human Adipose-Derived Stem Cells in Alzheimer's Disease Mouse Models

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2013

• Amyloid-beta peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes

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2012

• Therapeutic potentials of neural stem cells treated with fluoxetine in Alzheimer's disease

• The Role of S100a9 in the Pathogenesis of Alzheimer's Disease: The Therapeutic Effects of S100a9 Knockdown or Knockout

• The Preventive and Therapeutic Effects of Intravenous Human Adipose-Derived Stem Cells in Alzheimer's Disease Mice

• Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells

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Patent

2022

• 아밀로이드 베타 특이적 펩타이드 CBRV1-04369 및 이를 포함하는 알츠하이머병 치료용 조성물(Amyloid beta-specific peptide CBRV1-04369 and a composition for treating Alzheimer's disease comprising the same) / 10-2022-0097555

• 아밀로이드 베타 특이적 펩타이드 SMA_04088-2 및 이를 포함하는 알츠하이머병 치료용 조성물(Amyloid beta-specific peptide SMA_04088-2 and a composition for treating Alzheimer's disease comprising the same) / 10-2022-0097554

• N-[(4'-브로모[1,1'-바이페닐]-4-일)설포닐]-L-발린 또는 이의 약제학적으로 허용 가능한 염을 포함하는 아밀로이드 베타의 올리고머화 및 피브릴화 억제용 조성물 / PCT/KR2022/007251

2021

• 기저측편도체의 자극을 통한 스트레스에 대한 취약성을 가지는 동물 모델 제조방법 및 이를 이용한 스트레스에 대한 회복력을 증강시키는 약물의 스크리닝 방법 / 10-2021-0180692

• 3-페닐-2H-크로멘 유도체 및 이를 함유하는 알츠하이머의 예방 또는 치료용 약학적 조성물 / PCT/KR2021/011746

• N-[(4'-브로모[1,1'-바이페닐]-4-일)설포닐]-L-발린 또는 이의 약제학적으로 허용 가능한 염을 포함하는 아밀로이드 베타의 올리고머화 및 피브릴화 억제용 조성물(Composition for Inhibiting Oligomerization and Fibrillization of Amyloid Beta Comprising N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine or Pharmaceutically Acceptable Salt Thereof) / 10-2021-0065823

• Iba-1, TNF-α, IL-1β 및 GFAP를 이용한 청년기 우울증 판단 정보를 제공하는 방법(Information offering method for young adulthood depression using Iba-1, TNF-α, IL-1β and GFAP) / 10-2021-0049050

• Iba-1, TNF-α, IL-1β 및 IL-17를 이용한 청년기 우울증 판단 정보를 제공하는 방법(Information offering method for young adulthood depression using Iba-1, TNF-α, IL-1β and IL-17) / 10-2021-0049042

• 폴리코사놀을 유효성분으로 함유하는 기억 및 인지 기능 개선용 조성물 및 알츠하이머 예방 또는 개선용 조성물 / 10-2021-0004419

2020

• 청년기 우울증 질환을 진단하기 위한 조성물 및 키트(Composition and kit for diagnosing young adulthood depression) / 10-2020-0080388

• 알츠하이머 질환의 글루코스 대사 조절제 및 이를 스크리닝하는 방법(Modulator of glucose metabolism in Alzheimer's disease and screening method for the modulator) / 10-2020-0058548

2019

• 청년기 우울증 동물모델의 제조방법(Method for producing animal model having young adulthood depression) / 10-2019-0089150

2018

• 알츠하이머병 동물모델로서의 6×FAD 마우스 및 이의 용도(6×FAD mouse as an animal model of Alzheimer's disease and use thereof) / 10-2018-0137391

• 청년기 우울증 동물모델의 제조방법 / 10-2018-0129089

• 콧물 시료를 이용하여 경도 및 중도 알츠하이머 질환을 구분하여 진단하기 위한 조성물 및 키트 / 10-2018-0042631

• 콧물 시료의 베타 아밀로이드 올리고머를 이용한 알츠하이머 질환의 진행 단계 스크리닝용 조성물 및 이를 이용한 알츠하이머 질환의 진행 단계 스크리닝 방법(Composition for screening stage of Alzheimer's  disease progression using amyloid beta oligomer in  nasal fluid and method for screening stage of  Alzheimer's disease progression using the same) / 10-2018-0005761

2017

• 타우 단백질의 발현수준을 측정하는 제제를 포함하는 알츠하이머 중증도 진단용 조성물 및 이를 이용한 알츠하이머 중증도의 진단방법 / 10-2017-0144000

• 콧물 시료를 이용한 알츠하이머 질환의 진행 단계 스크리닝 방법 (Method for screening stage of Alzheimer''s disease progression using nasal fluid) / 10-2017-0127707

2016

• 뉴레귤린-1 단백질을 이용한 알츠하이머 병 진단용 조성물 및 이를 이용한 알츠하이머 병의 진단방법(DIAGNOSTIC COMPOSITION OF ALZHEIMER''S DISEASE USING  NEUREGULIN-1 PROTEIN AND DIAGNOSTICS METHOD OF  ALZHEIMER''S DISEASE USING THE SAME) / 10-2016-0184244

2015

• 콧물 시료를 이용한 뇌신경 질환의 진단용 조성물(Composition for diagnosing neurological disease using nasal mucus) / 10-2015-0083597

2010

• Pharmaceutical composition for treating dementia comprising ShRNA inhibiting S100a9 expression / 12851273

• S100a9 의 발현을 억제하는 shRNA를 포함하는  치매 치료용 약학 조성물(Pharmaceutical composition for treating dementia  comprising shRNA inhibiting S100a9 expression) / 10-2010-0050864