News

• [Publication] 2022.11. We constructed the first comprehensive dynamic quantitative model of the mTOR signaling pathway and applied it to study the infection of SARS-CoV-2. This model can be used as a platform for investigating novel therapeutic strategies and administration times against COVID-19. The related works have been published in the Proceedings of IEEE BIBE 2022.

• [Industry-academia Cooperation] 2021.01. We sign the contract of industry-academia cooperation with Genesys Logic to develop AI-powered liver health diagnostic methods.

• [Publication] 2020.07. We collaborated with Academia Sinica and Assiut University, Egypt to develop the nutrient sialic acid derivatives as potent Siglec-2/CD22 inhibitors. The related works have been published in the European Journal of Medicinal Chemistry (SCI, IF=5.572, 5/61, CHEMISTRY, MEDICINAL).

• [Master's degree] 2020.07. Congratulations to Ms. Nien-Wei Chou for graduating with a Master's degree! (Thesis: Effects of Ketogenic Diet on Biological Pathways in Liver, Brain, and Heart)

• [Awarded] 2019.10. Our PI Dr. Yu-Yao Tseng received the Newly-recruited Faculty Excellence Award with Flexible Salary Reward from Shih Chien University.

• [Awarded] 2019.07. The lecture "Applications of Big Data in the Food and Nutrition Field" given by our PI Dr. Yu-Yao Tseng is awarded the Outstanding Featured Benchmark Program from Shih Chien University.

• [Invited talk] 2019.05. Our PI Dr. Yu-Yao Tseng is invited to the 45th Annual Conference of the Nutrition Society of Taiwan as a keynote speaker.

• [Invited talk] 2019.04. Our PI Dr. Yu-Yao Tseng is invited by the Industrial Innovation R&D office, Shih Chien University to give a technical lecture about the applications of big data and AI.

• [Invited talk] 2018.11. Our PI Dr. Yu-Yao Tseng is invited to the 48th Annual Conference of the Taiwan Association for Food Science and Technology as a keynote speaker.

Publications

1. Yu-Yao Tseng* (2022, Nov). Modeling the effects of SARS-CoV-2 infection on the mTOR signaling pathway. 2022 IEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE), 193-198.

2. Hajjaj H.M. Abdu-Allah*, Shang-Chuen Wu, Chun-Hung Lin, Yu-Yao Tseng* (2020, Jul). Design, synthesis and molecular docking study of α-triazolylsialosides as non-hydrolyzable and potent CD22 ligands. European Journal of Medicinal Chemistry, 208:112707.

3. Jung-Yu Lee, Si-Yu Lin, Chun-Yu Lin, Yi-Hsuan Chuang, Sing-Han Huang, Yu-Yao Tseng, Hung-Jung Wang, Jinn-Moon Yang* (2019, May). Identification of the PCA29 gene signature as a predictor in prostate cancer. Journal of Bioinformatics and Computational Biology, 17(3), 1940006.

4. Sing-Han Huang, Yu-Shu Lo, Yong-Chun Luo, Yu-Yao Tseng, and Jinn-Moon Yang* (2018, Mar). A homologous mapping method for three-dimensional reconstruction of protein networks reveals disease-associated mutations. BMC Systems Biology, 12(Suppl 2), 13.

5. Tung-Ju Hsien, Hsien-Ya Lin, Zhijay Tu, Ting-Chien Lin, Shang-Chuen Wu, Yu-Yao Tseng, Fu-Tong Liu, Shang-Tw Danny Hsu and Chun-Hung Lin* (2016, Jun). Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors. Scientific Reports, 15;6:29457.

6. Yu-Yao Tseng, Suzanne M. Hunt, Christian Heintzen, Susan K. Crosthwaite* and Jean-Marc Schwartz*. (2012, Mar). Comprehensive modelling of the Neurospora circadian clock and its temperature compensation. PLoS Computational Biology, 8(3):e1002437.

7. Guang-Jan Lin, Ting-Yu Liu, Yu-Yao Tseng, Zeng-Weng Chen, Chia-Chin You, Shih-Ling Hsuan, Maw-Sheng Chien, Chienjin Huang*. (2009, Nov). Yeast-expressed classical swine fever virus glycoprotein E2 induces a protective immune response. Veterinary Microbiology, 139(3-4):369-74.

8. Pei-Ching Wu, Maw-Sheng Chien, Yu-Yao Tseng, Jiarong Lin, Wei-Li Lin, Cheng-Yao Yang, Chienjin Huang*. (2008, Jan). Expression of the porcine circovirus type 2 capsid protein subunits and application to an indirect ELISA. Journal of biotechnology, 133(1):58-64.

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