News

• [Publication] Oct 2024. We developed a quantitative systems biology model to investigate the interaction mechanisms between the circadian clock and SARS-CoV-2 infection. Through integrated analysis of chronobiology and pharmacology, we identified the optimal therapeutic time for antiviral treatment that enhance therapeutic efficacy while minimizing circadian perturbation. This research has been published in CPT Pharmacometrics & Systems Pharmacology, providing innovative insights and methodologies for COVID-19 chronotherapy and precision medicine development. 

• [Publication] 2024.08. We employed mathematical modeling to compare the effects of high-fat diet and ketogenic diet on cardiac PI3K-Akt signaling. The study revealed that, compared to the high-fat diet, the ketogenic diet reduced cardiomyocyte apoptosis. Our findings were published in Nutrition & Metabolism, offering new perspectives for precision nutrition and therapeutic strategy development.

• [Publication] 2024.05. We analyzed seasonal beverage preferences in Taiwan using Google Trends and weather data. Results published in ICHTL 2024, demonstrating big data applications in the food industry.

• [Invited Talk] 2024.04. Our PI was invited to the EMI Teacher Workshop at Shih Chien University as the keynote speaker for "EMI Teaching Experience Sharing."

• [Publication] 2024.02. We collaborated with NYCU to develop the Gscore gene set correlation enrichment analysis method, applicable to cancer and COVID-19 research. The related works have been published in Nucleic Acids Research.

• [Awarded] 2024.01. Our PI Dr. Yu-Yao Tseng received the "Faculty Award for Teaching Courses in English" from Shih Chien University.

• [Invited Talk] 2023.10. Our PI was invited to the "Programming Education" Teacher Professional Community at Shih Chien University as the main speaker for "Course Discussion and Experience Sharing."

• [Awarded] 2023.07. Our laboratory was awarded a grant from the Ministry of Science and Technology to conduct an "Undergraduate Student Research Project." (Student: Hsuan-Hui Wu; Project Title: Research on the Correlation between Diet and Cultural Habits Using Big Data)

• [Awarded] 2023.07. Our PI Dr. Yu-Yao Tseng was assigned by Shih Chien University to participate in the Bilingual Seed Teacher Training Program. He attended a training program at Queen's University Belfast in Northern Ireland, UK.

• [Invited Talk] 2023.06. Our PI Dr. Yu-Yao Tseng was invited to serve as the college lead instructor for the EMI Expert Panel Discussion at Shih Chien University.

• [Master's degree] 2023.01. Congratulations to Mr. David Wang for graduating with a Master's degree! (Thesis: The Application of Machine Learning on The Non-invasive Diagnosis of Coronary Artery Disease)

• [Publication] 2022.11. We constructed the first comprehensive dynamic quantitative model of the mTOR signaling pathway and applied it to study the infection of SARS-CoV-2. This model can be used as a platform for investigating novel therapeutic strategies and administration times against COVID-19. The related works have been published in the Proceedings of IEEE BIBE 2022.

• [Industry-academia Cooperation] 2021.01. We sign the contract of industry-academia cooperation with Genesys Logic to develop AI-powered liver health diagnostic methods.

• [Publication] 2020.07. We collaborated with Academia Sinica and Assiut University, Egypt to develop the nutrient sialic acid derivatives as potent Siglec-2/CD22 inhibitors. The related works have been published in European Journal of Medicinal Chemistry (SCI, IF=5.572, 5/61, CHEMISTRY, MEDICINAL).

• [Master's degree] 2020.07. Congratulations to Ms. Nien-Wei Chou for graduating with a Master's degree! (Thesis: Effects of Ketogenic Diet on Biological Pathways in Liver, Brain, and Heart)

• [Awarded] 2019.10. Our PI Dr. Yu-Yao Tseng received the Newly-recruited Faculty Excellence Award with Flexible Salary Reward from Shih Chien University.

• [Awarded] 2019.07. The lecture "Applications of Big Data in the Food and Nutrition Field" given by our PI Dr. Yu-Yao Tseng is awarded the Outstanding Featured Benchmark Program from Shih Chien University.

• [Invited talk] 2019.05. Our PI Dr. Yu-Yao Tseng is invited to the 45th Annual Conference of the Nutrition Society of Taiwan as a keynote speaker.

• [Invited talk] 2019.04. Our PI Dr. Yu-Yao Tseng is invited by the Industrial Innovation R&D office, Shih Chien University to give a technical lecture about the applications of big data and AI.

• [Invited talk] 2018.11. Our PI Dr. Yu-Yao Tseng is invited to the 48th Annual Conference of the Taiwan Association for Food Science and Technology as a keynote speaker.

Publications

1. Yu-Yao Tseng* (2024, Oct). A theoretical systems chronopharmacology approach for COVID-19: Modeling circadian regulation of lung infection and potential precision therapies. CPT Pharmacometrics & Systems Pharmacology, 14(2):340-350.

2. Yu-Yao Tseng* (2024, Aug). Comparative mathematical modeling reveals the differential effects of high-fat diet and ketogenic diet on the PI3K-Akt signaling pathway in heart. Nutrition & Metabolism, 21, 65.

3. Yu-Yao Tseng*, Hsuan-Hui Wu (2024, May). Deciphering regional preferences for seasonal beverages in Taiwan: A rhythmicity and correlation analysis of Google search trends and weather data. 2024 International Conference on Hospitality, Tourism and Leisure: Technology, Innovation, and Sustainability (ICHTL), 1-18-1~1-18-20.

4. Lan-Yun Chang, Meng-Zhan Lee, Yujia Wu, Wen-Kai Lee, Chia-Liang Ma, Jun-Mao Chang, Ciao-Wen Chen, Tzu-Chun Huang, Chia-Hwa Lee, Jih-Chin Lee, Yu-Yao Tseng, Chun-Yu Lin* (2024, Feb). Gene set correlation enrichment analysis for interpreting and annotating gene expression profiles. Nucleic acids research, 52(3):e17.

5. Yu-Yao Tseng* (2022, Nov). Modeling the effects of SARS-CoV-2 infection on the mTOR signaling pathway. 2022 IEEE 22nd International Conference on Bioinformatics and Bioengineering (BIBE), 193-198.

6. Hajjaj H.M. Abdu-Allah*, Shang-Chuen Wu, Chun-Hung Lin, Yu-Yao Tseng* (2020, Jul). Design, synthesis and molecular docking study of α-triazolylsialosides as non-hydrolyzable and potent CD22 ligands. European Journal of Medicinal Chemistry, 208:112707.

7. Jung-Yu Lee, Si-Yu Lin, Chun-Yu Lin, Yi-Hsuan Chuang, Sing-Han Huang, Yu-Yao Tseng, Hung-Jung Wang, Jinn-Moon Yang* (2019, May). Identification of the PCA29 gene signature as a predictor in prostate cancer. Journal of Bioinformatics and Computational Biology, 17(3), 1940006.

8. Sing-Han Huang, Yu-Shu Lo, Yong-Chun Luo, Yu-Yao Tseng, and Jinn-Moon Yang* (2018, Mar). A homologous mapping method for three-dimensional reconstruction of protein networks reveals disease-associated mutations. BMC Systems Biology, 12(Suppl 2), 13.

9. Tung-Ju Hsien, Hsien-Ya Lin, Zhijay Tu, Ting-Chien Lin, Shang-Chuen Wu, Yu-Yao Tseng, Fu-Tong Liu, Shang-Tw Danny Hsu and Chun-Hung Lin* (2016, Jun). Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors. Scientific Reports, 15;6:29457.

10. Yu-Yao Tseng, Suzanne M. Hunt, Christian Heintzen, Susan K. Crosthwaite* and Jean-Marc Schwartz*. (2012, Mar). Comprehensive modelling of the Neurospora circadian clock and its temperature compensation. PLoS Computational Biology, 8(3):e1002437.

11. Guang-Jan Lin, Ting-Yu Liu, Yu-Yao Tseng, Zeng-Weng Chen, Chia-Chin You, Shih-Ling Hsuan, Maw-Sheng Chien, Chienjin Huang*. (2009, Nov). Yeast-expressed classical swine fever virus glycoprotein E2 induces a protective immune response. Veterinary Microbiology, 139(3-4):369-74.

12. Pei-Ching Wu, Maw-Sheng Chien, Yu-Yao Tseng, Jiarong Lin, Wei-Li Lin, Cheng-Yao Yang, Chienjin Huang*. (2008, Jan). Expression of the porcine circovirus type 2 capsid protein subunits and application to an indirect ELISA. Journal of biotechnology, 133(1):58-64.

Lab Alumni