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Our mission is to help patients who have heart failure by bridging the scientific gaps between molecular, cellular and organ-level function.

If you are a patient, or you care about somebody who has heart disease, you can learn more about heart failure at Heart Failure 101.

We work as a team to integrate experimental and computational techniques with the goal of developing better therapies for patients who have heart failure. Working in collaboration with clinicians at the University of Kentucky, we have created a large biobank of human myocardium (>10,000 samples from ~400 organ donors and patients). We use these samples to accelerate translational research.

Our work is grounded in sarcomere-level mechanics and mathematical modeling but not extends beyond the myofilaments to explore ventricular remodeling, organ-level function, whole-body hemodynamics, and myocardial recovery induced by ventricular unloading.