We are actively pursuing the development of In-situ NMR methods to investigate membrane proteins and transthyretin-related familial amyloid polyneuropathy (TTR-FAP)..
Publications
Cheng-Hsun Hsu, Hsin-Yu Yu, Ho Jun Lee, Pei-Hao Wu, Shing-Jong Huang, Jong Suk Lee*, Tsyr-Yan Yu*, Yi-Pei Li*, Dun-Yen Kang*, "Fast Water Transport in UTSA-280 via a Knock-off Mechanism." Angew. Chem.Int. Ed.2023, 62, e202309874.
DOI: 10.1002/anie.202309874
Fang-Hsuan Hu, Li-Tang Chi, Guan-Bo Syu, Tsyr-Yan Yu, Ming-Pei Lin, Jiun-Jen Chen, Wen-Yueh Yu, Dun-Yen Kang, "Mixed-linker MOF-303 membranes for pervaporation". Journal of Membrane Science Letters, 3, 100053 (2023).
Yi-Rui Zhong, Tsyr-Yan Yu*, Li-Kang Chu*,
“Roles of functional lipids in bacteriorhodopsin photocycle in various delipidated purple membranes”. Biophysical Journal, 121(10), 1789-1798 (2022) https://doi.org/10.1016/j.bpj.2022.04.022
Cheng-Chieh Lin , Shing-Jong Huang , Pei-Hao Wu , Tzu-Pei Chen , Chih-Ying Huang , Ying-Chiao Wang , Po-Tuan Chen , Denitsa Radeva , Ognyan Petrov , Vladimir Gelev , Raman Sankar , Chia-Chun Chen , Chun-Wei Chen*, Tsyr-Yan Yu*, “Direct Investigation of the Reorientational Dynamics of A-site Cations in 2D Organic-Inorganic Hybrid Perovskite by Solid-State NMR”. Nature Communications, 13, 1513 (2022). https://doi.org/10.1038/s41467-022-29207-6
C-H Liu, S-J Huang*, Tsyr-Yan Yu*, “Cholesterol Modulates the Interaction between HIV-1 Viral Protein R and Membrane”. Membranes, 11(10), 784 (2021).
PB Zhong, C-H Liu, Y-T Chen*, T-Y Yu*, “The Study of HIV-1 Vpr-Membrane and Vpr-hVDAC-1 Interactions by Graphene Field-Effect Transistor Biosensors”. ACS. Appl. Bio. Mater., 3(9), 6351-6357 (2020).
R Ibrahim, S-Y Yeh, K-P Lin, F Ricardo, T-Y Yu, C-C Chan, J-W Tsai*, Y-T Liu*, “Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration”. Cell. Mol. Life Sci., 77(7), 1421-1434 (2020).
Feng-Jen Hsieh, Shingo Sotoma, Hsin-Hung Lin, Ching-Ya Cheng, Tsyr-Yan Yu, Chia-Lung Hsieh, Chun-Hung Lin*, and Huan-Cheng Chang*,
“Bioorthogonal Fluorescent Nanodiamonds for Continuous Long-Term Imaging and Tracking of Membrane Proteins.” ACS Appl. Mater. Interfaces, 11(22), 19774–19781 (2019) https://doi.org/10.1021/acsami.9b03640
Y-T Liu, Y-J Yen, F Ricardo, Y Chang, P-H Wu, S-J Huang, K-P Lin*, T-Y Yu*, “Biophysical characterization and modulation of Transthyretin Ala97Ser”. Ann. Clin. Transl. Neur., 6(10), 1961-1970(2019).
Y-M Kao, C-H Cheng, M-L Syue, H-Y Huang, I-C Chen*, T-Y Yu*, L-K Chu*, “Photochemistry of Bacteriorhodopsin with Various Oligomeric Statuses in Controlled Membrane Mimicking Environments: A Spectroscopic Study from Femtoseconds to Milliseconds.” J. Phys. Chem. B, 123(9), 2032-2039 (2019).
H. Y. Huang, M. L. Syue, I. C. Chen, T. Y. Yu, L. K. Chu, “Influence of Lipid Compositions in the Events of Retinal Schiff Base of Bacteriorhodopsin Embedded in Covalently Circularized Nanodiscs: Thermal Isomerization, Photoisomerization, and Deprotonation”. J. Phys. Chem. B, 123(43), 9123-9133 (2019).
M. T. Eddy, T. Y. Yu, G. Wagner, R. G. Griffin*, “Structural characterization of the human membrane protein VDAC2 in lipid bilayers by MAS NMR”.
J. Biomol. NMR, 73(8-9), 451-460 (2019).
Y Yusuf, J Massiot, Y-T Chang, P-H Wu, V Yeh, P-C Kuo, J Shiue*, T-Y Yu*, “Optimization of the Production of Covalently Circularized Nanodiscs and Their Characterization in Physiological Conditions”.
Langmuir, 34(11), 3525-3532 (2018).
V Yeh, T-Y Lee, C-W Chen, P-C Kuo, J Shiue, L-K Chu,* and T-Y Yu*, “Highly Efficient Transfer of 7TM Membrane Protein from Native Membrane to Covalently Circularized Nanodisc”. Sci. Rep., 8, 13501 (2018).
I Shown, S Samireddi, Y-C Chang, R Putikam, P-H Chang, A Sabbah, F-Y Fu, W-F Chen, C-I Wu, T-Y Yu, P-W Chung, M C Lin, L-C Chen* and K-H Chen*, “Carbon-doped SnS2 nanostructure as a high-efficiency solar fuel catalyst under visible light”. Nat. Commun., 9, 169 (2018).
O Shih, Y-Q Yeh, K-F Liao, C-J Su, P-H Wu, R Heenan, T-Y Yu*, and U-S Jeng*, “Membrane Charging and Swelling upon Calcium Adsorption as Revealed by Phospholipid Nanodiscs.” J. Phys. Chem. Lett., 9(15), 4287-4293 (2018).
V Yeh, Y Hsin, T-Y Lee, J C C Chan, T-Y Yu*, and L-K Chu*, “Lipids influence the proton pump activity of photosynthetic protein embedded in nanodiscs”. Rsc. Adv., 6(91), 88300-88305 (2016).
A Viegas, T Viennet, T-Y Yu, F Schumann, W Bermel, G Wagner, M Etzkorn*, “UTOPIA NMR: activating unexploited magnetization using interleaved low-gamma detection”. J Biomol NMR, 64(1), 9-15 (2016).
T-Y Lee, V Yeh, J Chuang, J C C Chan, L-K Chu*, T-Y Yu*, “Tuning the Photocycle Kinetics of Bacteriorhodopsin in Lipid Nanodiscs”. Biophys J., 109(9), 1899-1906 (2015).
M. T. Eddy, T. Y. Yu*, “Membranes, peptides, and disease: Unraveling the mechanisms of viral proteins with solid state nuclear magnetic resonance spectroscopy”. Solid State Nucl Mag 61-62, 1-7 (2014).
P Coote*, K Leigh, T-Y Yu*, N Khaneja, G Wagner, H Arthanari,
“A new broadband homonuclear mixing pulse for NMR with low applied power”. J. Chem. Phys. 141(2), 024201(2014).
S J Kim, M Singh, A Wohlrab, T-Y Yu, G J Patti, R D O'Connor, M VanNieuwenhze *, J Schaefer. “The Isotridecanyl Side Chain of Plusbacin-A(3) Is Essential for the Transglycosylase Inhibition of Peptidoglycan Biosynthesis”. Biochemistry, 52(11), 1973-1979 (2013).
P Coote*, H Arthanari, T-Y Yu, A Natarajan, G Wagner, N Khaneja, “Pulse design for broadband correlation NMR spectroscopy by multi-rotating frames”. J. Biomol NMR, 55(3), 291-302 (2013).
T-Y Yu, T. Raschle, S. Hiller, G. Wagner*, “Solution NMR spectroscopic characterization of human VDAC-2 in detergent micelles and lipid bilayer nanodiscs”. BBA-Biomembranes, 1818(6), 1562-1569 (2012).
J. S. Li*, J. Ruths, T-Y Yu, H. Arthanari, G. Wagner, “Optimal pulse design in quantum control: A unified computational method”, Proc. Natl. Acad. Sci, USA, 108(5), 1879-1884 (2011).
T-Y Yu, M. Singh, S. Matsuoka, G J Patti, G. S. Potter, J Schaefer*,
“Variability in C-3-Plant Cell-Wall Biosynthesis in a High-CO2 Atmosphere by Solid-State NMR Spectroscopy”. J. Am. Chem. Soc., 132(18), 6335-6341 (2010).
D. Stueber D., T-Y Yu, B. Hess, K. Kremer, R D O'Connor, J Schaefer*,
“Chain packing in polycarbonate glasses”. J. Chem. Phys., 132(10), 104901(2010).
T Gullion, T-Y Yu, M Singh, G J Patti, G S Potter, J Schaefer*, “Oxygen-17 Appears Only in Protein in Water-Stressed Soybean Leaves Labeled by 17O2”. J. Am. Chem. Soc., 132(31), 10802-10807 (2010).
T. Raschle, S. Hiller, T-Y Yu, A J Rice, T Walz, G Wagner*, “Structural and Functional Characterization of the Integral Membrane Protein VDAC-1 in Lipid Bilayer Nanodiscs”. J. Am. Chem. Soc., 131(49), 17777-17779 (2009).
G J Patti, SJ Kim, T-Y Yu, E. Dietrich, K. S. E Tanaka, T. R. Parr, A. R. Far, J Schaefer*, “Vancomycin and Oritavancin Have Different Modes of Action in Enterococcus faecium”. J. Mol. Biol., 392(5), 1178-1191 (2009).
T-Y Yu, J. Schaefer*, “REDOR NMR characterization of DNA packaging in bacteriophage T4”. J. Mol. Biol., 382(4), 1031-1042 (2008).
T-Y Yu, R. D. O'Connor, A. C. Sivertsen, C. Chiauzzi, B. Poliks, M. Fischer, A. Bacher, I. Haase, M. Cushman*, J Schaefer, “15N{31P} REDOR NMR Studies of the Binding of Phosphonate Reaction Intermediate Analogues to Saccharomyces cerevisiae Lumazine Synthase”. Biochemistry, 47(52), 13942-13951 (2008).
P. C. Jiang, T-Y Yu, W. C. Perng, L. P. Hwang*, “Pore-to-pore hopping model for the interpretation of the pulsed gradient spin echo attenuation of water diffusion in cell suspension systems”. Biophys J., 80(6), 2493-2504 (2001).
D. W. Hwang, A. K. Sinha, C. Y. Cheng, T-Y Yu, L. P. Hwang*, “Water dynamics on the surface of MCM-41 via 2H double quantum filtered NMR and relaxation measurements”. J. Phys. Chem. B, 105(24), 5713-5721 (2001).
T-Y Yu, C. Y. Cheng, D. W. Hwang, H. W. Huang, L. P. Hwang*, “Water-filled MCM-41 characterized by double-quantum-filtered 2H NMR spectral analysis”. Appl. Magn. Reson., 18(3), 435-453 (2000).
N. Hedin, T-Y Yu, I. Furo*, “Growth of C12E8 micelles with increasing temperature. A convection-compensated PGSE NMR study”, Langmuir, 16(19), 7548-7550 (2000).
背景圖 畫家: 余享諦