From Northwestern Pennsylvania: Take I-79 to Rt. 422 East to Ebensburg. In town, turn left at the traffic light onto High Street. Continue straight at next light. Turn left on to Manor Road. Saint Francis University is six miles on the right.

From Cleveland (Ohio area): Take Ohio Turnpike East to I-80 East. Take I-680 South to Route 422 East (approximately 120 miles) to Ebensburg. In town, turn left at the traffic light onto High Street. Continue straight at next light. Turn left on to Manor Road. Follow this road for six miles to the Saint Francis University entrance on right.

From Southwestern PA and Southeast Ohio: Take Route 22 East from Pittsburgh to second Ebensburg exit (Ebensburg/Loretto exit). Bear right at end of exit ramp. Proceed straight (crossing over Route 22). Turn right at the first light on to Manor Road. Follow this road for six miles to the Saint Francis University entrance on right.

From Northeastern PA/Central New Jersey: Take I-80 South to I-80 West to Exit 161 (Bellefonte). Take US99/Rt. 220 South approximately 50 miles to Altoona. Take Rt. 22 West to Lilly/Portage Exit. Turn right onto Rt. 53 North. Continue on Rt. 53 North approximately two miles to traffic light (Sheetz on left). Turn left at light and continue beneath railroad overpass. 200 yards beyond overpass, bear right at Saint Francis University sign onto St. Joseph Street. Take this road four miles to Loretto. At Village Cross monument on traffic circle, bear left. Saint Francis University entrance is 200 yards on left.

From Southeastern PA, Baltimore, MD, and Washington, D.C.: Take PA Turnpike (I-76) West to Bedford Exit 146 (220 North/I-99 North). Turn left after toll booth. At top of hill, turn left onto US99/Rt. 220 North to Altoona. Travel approximately 30 miles to Rt. 22 West. Continue from Altoona -- see previous paragraph.