Publications

At F&M

(* denotes undergraduate co-author)

DeSimone, C. A.*; Naqvi, S. L.*; Tasker, S. Z. ThioCORMates: Tunable and Cost-Effective Carbon Monoxide-Releasing Molecules. Chem. Eur. J. 2022, e202201326. https://doi.org/10.1002/chem.202201326

Two of these reagents are now available to purchase from Sigma-Aldrich: phenyl thioCORMate (#930059) & p-NO2-phenyl thioCORMate (#930105)!
Featured in ChemistryViews: New CO-Releasing Molecules. 5/30/2022. https://www.chemistryviews.org/new-co-releasing-molecules/
See a video demonstration of these reagents on YouTube: https://www.youtube.com/watch?v=4RQ9QLj9zH8

Prior to F&M

(* denotes undergraduate co-author)

Kelly, A. M.; Berry, M. R.; Tasker, S. Z.; McKee, S. A.; Fan, T. M.; Hergenrother, P. J. Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy. J. Am. Chem. Soc. 2022, 144, 12367–12380. https://doi.org/10.1021/jacs.2c03944

Tasker, S. Z.; Cowfer, A. E.*; Hergenrother, P. J. Preparation of Structurally Diverse Compounds from the Natural Product Lycorine. Org. Lett. 2018, 20, 5894–5898. https://doi.org/10.1021/acs.orglett.8b02562

Gates, Z. P.; Vinogradov, A. A.; Quartararo, A. J.; Bandyopadhyay, A.; Choo, Z.-N.; Evans, E. D.; Halloran, K. H.; Mijalis, A. J.; Mong, S. K.; Simon, M. D.; Standley, E. A.; Styduhar, E. D.; Tasker, S. Z.; Touti, F.; Weber, J. M.; Wilson, J. L.; Jamison, T. F.; Pentelute, B. L. ‘Xenoprotein’ Engineering via Synthetic Libraries. Proc. Natl. Acad. Sci. 2018, 115, E5298–E5306. https://doi.org/10.1073/pnas.1722633115

Tasker, S. Z.; Jamison, T. F. Highly Regioselective Indoline Synthesis under Nickel/ Photoredox Dual Catalysis. J. Am. Chem. Soc. 2015, 137, 9531–9534. https://doi.org/10.1021/jacs.5b05597

Standley, E. A.† Tasker, S. Z.†; Jensen, K. L.; Jamison, T. F. Nickel Catalysis: Synergy between Method Development and Total Synthesis. Acc. Chem. Res. 2015, 48, 1503–1514. († indicates equal authorship) https://doi.org/10.1021/acs.accounts.5b00064

Tasker, S. Z.†; Standley, E. A.†; Jamison, T. F. Recent Advances in Homogeneous Nickel Catalysis. Nature 2014, 509, 299–309. († indicates equal authorship) https://doi.org/10.1038/nature13274

Tasker, S. Z.; Gutierrez, A. C.; Jamison, T. F. Nickel-Catalyzed Mizoroki–Heck Reaction of Aryl Sulfonates and Chlorides with Electronically Unbiased Terminal Olefins: High Selectivity for Branched Products. Angew. Chem., Int. Ed. 2013, 53, 1858–1861. https://doi.org/10.1002/anie.201308391

Tasker, S. Z.*; Bosscher, M. A.*; Shandro, C. A.*; Lanni, E. L.*; Ryu, K. A.*; Snapper, G. S.*; Utter, J. M.*; Ellsworth, B. A.; Anderson, C. E. Preparation of N-Alkyl 2-Pyridones via a Lithium Iodide Promoted O- to N-Alkyl Migration: Scope and Mechanism. J. Org. Chem. 2012, 77, 8220–8230. https://doi.org/10.1021/jo3015424

Tasker, S. Z.*; Brandsen, B. M.*; Ryu, K. A.*; Snapper, G. S.*; Staples, R. J.*; DeKock, R. L.; Anderson, C. E. Synthesis of a New Class of β-Iodo N-Alkenyl 2-Pyridones. Org. Lett. 2011, 13, 6224–6227. https://doi.org/10.1021/ol202679t

Hergenrother, P. J.; Richter, M.; Riley, A.; Drown, B.; Chavez, M.; Tasker, S.; Garcia, A. Small-Molecules Active Against Gram-Negative Bacteria. International Patent WO2017/156519A1, Sept. 2017.

Presentations

Exploring the Chemistry of S-Aryl Thioformates. American Chemical Society National Meeting, San Diego, CA. 3/23/3022. (Invited Talk; in-person), Session: ACS Petroleum Research Fund at 65.

Featuring work from: DeSimone, C. A.*; Naqvi, S. L.*; Mautone, O. N.*; Alagic, D.*

From Toxic Gases to Antibiotic Development: Using Organic Synthesis to Solve Real-World Problems. Elizabethtown College Seminar Series. 10/29/2021. (Invited Talk; in-person)

Featuring work from: DeSimone, C. A.*; Naqvi, S. L.*; Mautone, O. N.*; Alagic, D.*; Fahey, J.*; Campbell, K. A.*; Hoang, A.*; Yu, H.*

Photochemical Reactions of S-Aryl Thioformates: Toward a Synthesis of Oxetanes via Formal Formylation. American Chemical Society National Meeting, Philadelphia, PA, 4/9/2021. (Invited Talk; virtual), Session: Successful Products and Models of Undergraduate-Based Research: Good Science, Better Scientists.

Featuring work from: Mautone, O. N.*; Alagic, D.*

Photochemical Reactions of S-Aryl Thioformates: Toward a Synthesis of Oxetanes via Formal Formylation. American Chemical Society National Organic Symposium, Bloomington, IN, 06/24/2019. (Poster).

Featuring work from: Mautone, O. N.*; Alagic, D.*

Prior to F&M

Tasker, S. Z.; Hergenrother, P. J. Synthesis and Evaluation of a Collection of Complex Molecules to Investigate Active Transport at the Blood–Brain Barrier. High Throughput Chemistry and Chemical Biology, Gordon Research Conference, Andover, NH, June 24–30, 2017. Poster.

Tasker, S. Z.; Jamison, T. F. The Nickel-Catalyzed Heck Reaction: Regiocontrol and Novel Reactivity. Organic Reactions & Processes, Gordon Research Conference, Smithfield, RI, July 13–18, 2014 Poster.

Tasker, S. Z.; Anderson, C. E. Synthesis of N-Alkyl Pyridones via and O- to N- Alkyl Migration: Mechanistic Studies. National Organic Symposium, Boulder, CO, June 7–11, 2009. Poster.

Tasker, S. Z.; Meyer, D. B. Desulfurization of Diesel Fuel: A Peptide Approach. American Chemical Society National Meeting, Philadelphia, PA, August 17–21, 2008. CHED-268 Poster.