(* denotes undergraduate co-author)
Hoang, N. L. T.*; Nsereko, N. N. P.*; Sheetz, S. A.*; Tasker, S. Z. Synthesis and Antibacterial Activity of Ficuseptine and its Derivatives: Determination of Structure–Activity Relationships. Synlett 2025, 36, 1049–1053. https://doi.org/10.1055/a-2490-2986
DeSimone, C. A.*; Naqvi, S. L.*; Tasker, S. Z. ThioCORMates: Tunable and Cost-Effective Carbon Monoxide-Releasing Molecules. Chem. Eur. J. 2022, e202201326. https://doi.org/10.1002/chem.202201326
Two of these reagents are now available to purchase from Sigma-Aldrich: phenyl thioCORMate (#930059) & p-NO2-phenyl thioCORMate (#930105)!
Featured in ChemistryViews: New CO-Releasing Molecules. 5/30/2022. https://www.chemistryviews.org/new-co-releasing-molecules/
See a video demonstration of these reagents on YouTube: https://www.youtube.com/watch?v=4RQ9QLj9zH8
(* denotes undergraduate co-author)
Kelly, A. M.; Berry, M. R.; Tasker, S. Z.; McKee, S. A.; Fan, T. M.; Hergenrother, P. J. Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy. J. Am. Chem. Soc. 2022, 144, 12367–12380. https://doi.org/10.1021/jacs.2c03944
Tasker, S. Z.; Cowfer, A. E.*; Hergenrother, P. J. Preparation of Structurally Diverse Compounds from the Natural Product Lycorine. Org. Lett. 2018, 20, 5894–5898. https://doi.org/10.1021/acs.orglett.8b02562
Gates, Z. P.; Vinogradov, A. A.; Quartararo, A. J.; Bandyopadhyay, A.; Choo, Z.-N.; Evans, E. D.; Halloran, K. H.; Mijalis, A. J.; Mong, S. K.; Simon, M. D.; Standley, E. A.; Styduhar, E. D.; Tasker, S. Z.; Touti, F.; Weber, J. M.; Wilson, J. L.; Jamison, T. F.; Pentelute, B. L. ‘Xenoprotein’ Engineering via Synthetic Libraries. Proc. Natl. Acad. Sci. 2018, 115, E5298–E5306. https://doi.org/10.1073/pnas.1722633115
Tasker, S. Z.; Jamison, T. F. Highly Regioselective Indoline Synthesis under Nickel/ Photoredox Dual Catalysis. J. Am. Chem. Soc. 2015, 137, 9531–9534. https://doi.org/10.1021/jacs.5b05597
Standley, E. A.† Tasker, S. Z.†; Jensen, K. L.; Jamison, T. F. Nickel Catalysis: Synergy between Method Development and Total Synthesis. Acc. Chem. Res. 2015, 48, 1503–1514. († indicates equal authorship) https://doi.org/10.1021/acs.accounts.5b00064
Tasker, S. Z.†; Standley, E. A.†; Jamison, T. F. Recent Advances in Homogeneous Nickel Catalysis. Nature 2014, 509, 299–309. († indicates equal authorship) https://doi.org/10.1038/nature13274
Tasker, S. Z.; Gutierrez, A. C.; Jamison, T. F. Nickel-Catalyzed Mizoroki–Heck Reaction of Aryl Sulfonates and Chlorides with Electronically Unbiased Terminal Olefins: High Selectivity for Branched Products. Angew. Chem., Int. Ed. 2013, 53, 1858–1861. https://doi.org/10.1002/anie.201308391
Tasker, S. Z.*; Bosscher, M. A.*; Shandro, C. A.*; Lanni, E. L.*; Ryu, K. A.*; Snapper, G. S.*; Utter, J. M.*; Ellsworth, B. A.; Anderson, C. E. Preparation of N-Alkyl 2-Pyridones via a Lithium Iodide Promoted O- to N-Alkyl Migration: Scope and Mechanism. J. Org. Chem. 2012, 77, 8220–8230. https://doi.org/10.1021/jo3015424
Tasker, S. Z.*; Brandsen, B. M.*; Ryu, K. A.*; Snapper, G. S.*; Staples, R. J.*; DeKock, R. L.; Anderson, C. E. Synthesis of a New Class of β-Iodo N-Alkenyl 2-Pyridones. Org. Lett. 2011, 13, 6224–6227. https://doi.org/10.1021/ol202679t
Hergenrother, P. J.; Richter, M.; Riley, A.; Drown, B.; Chavez, M.; Tasker, S.; Garcia, A. Small-Molecules Active Against Gram-Negative Bacteria. International Patent WO2017/156519A1, Sept. 2017.
(* denotes undergraduate co-author)
Synthesis of Thioethers via a Hypervalent Iodine-Catalyzed Thiol-Ene Reaction. National Organic Symposium, Troy, NY, 6/26/2025. (Poster).
Featuring work from: Balsubramanian, S.*, Gidwaney, Z. A.*, De Jesus, S.*
Development of Gas-Releasing Molecules Using a Thiol Carrier. National Organic Symposium, Troy, NY, 6/26/2025. (Poster).
Featuring work from: Weiss, T.N.*, Tavens, H.D.*, Ulman, T.A.*, Cevik, S.*, Doria, S.R.*, DeSimone, C.A.,* Naqvi, L.*
Development of CO-Releasing Molecules Designed around a Thiol Carrier. American Chemical Society National Meeting, Denver, CO. 7/9/2024. (Invited Talk), Session: Advances in Molecular Reactivity & Material Properties Enabled by Mechanistic & Structural Methods.
Featuring work from: Bachman, A.S.*, Tavens, H.D.*, Doria, S.R.*, Weiss, T.N.*, Sheetz, S. A.*, Nsereko, N.N.P.*, Broughton, D.P.*, Kelly, C. E.*, DeSimone, C. A.*; Naqvi, S. L.*
Development of CO-Releasing Molecules Designed around a Thiol Carrier. Organometallics Gordon Research Conference, Newport, RI. 7/9/2024. (Invited Talk).
Featuring work from: Bachman, A.S.*, Tavens, H.D.*, Doria, S.R.*, Weiss, T.N.*, Sheetz, S. A.*, Nsereko, N.N.P.*, Broughton, D.P.*, Kelly, C. E.*, DeSimone, C. A.*; Naqvi, S. L.*
From Carbon Monoxide Generation to Antibacterial Natural Products: Synthesis of Sulfur-Containing Compounds to Solve Real-World Problems. University of California, San Diego Seminar Series. 5/8/2023. (Invited Talk)
Featuring work from: DeSimone, C. A.*; Naqvi, S. L.*; Strachan, Z.*, Broughton, D. P.*, Mautone, O. N.*; Alagic, D.*; Fahey, J.*; Campbell, K. A.*; Hoang, A.*; Yu, H.*
ThioCORMates: Tunable and Cost-Effective Carbon Monoxide-Releasing Molecules. National Organic Symposium, San Diego, CA, 6/26/2022. (Poster).
Featuring work from: DeSimone, C. A.*; Naqvi, S. L.*
Exploring the Chemistry of S-Aryl Thioformates. American Chemical Society National Meeting, San Diego, CA. 3/23/3022. (Invited Talk; in-person), Session: ACS Petroleum Research Fund at 65.
Featuring work from: DeSimone, C. A.*; Naqvi, S. L.*; Mautone, O. N.*; Alagic, D.*
Photochemical Reactions of S-Aryl Thioformates: Toward a Synthesis of Oxetanes via Formal Formylation. American Chemical Society National Meeting, Philadelphia, PA, 4/9/2021. (Invited Talk), Session: Successful Products and Models of Undergraduate-Based Research: Good Science, Better Scientists.
Featuring work from: Mautone, O. N.*; Alagic, D.*
Photochemical Reactions of S-Aryl Thioformates: Toward a Synthesis of Oxetanes via Formal Formylation. National Organic Symposium, Bloomington, IN, 06/24/2019. (Poster).
Featuring work from: Mautone, O. N.*; Alagic, D.*
Additional seminar talks at: Elizabethtown College, Bucknell University, Lafayette College, Lebanon Valley College
Tasker, S. Z.; Hergenrother, P. J. Synthesis and Evaluation of a Collection of Complex Molecules to Investigate Active Transport at the Blood–Brain Barrier. High Throughput Chemistry and Chemical Biology, Gordon Research Conference, Andover, NH, June 24–30, 2017. Poster.
Tasker, S. Z.; Jamison, T. F. The Nickel-Catalyzed Heck Reaction: Regiocontrol and Novel Reactivity. Organic Reactions & Processes, Gordon Research Conference, Smithfield, RI, July 13–18, 2014 Poster.
Tasker, S. Z.; Anderson, C. E. Synthesis of N-Alkyl Pyridones via and O- to N- Alkyl Migration: Mechanistic Studies. National Organic Symposium, Boulder, CO, June 7–11, 2009. Poster.
Tasker, S. Z.; Meyer, D. B. Desulfurization of Diesel Fuel: A Peptide Approach. American Chemical Society National Meeting, Philadelphia, PA, August 17–21, 2008. CHED-268 Poster.