The UC San Diego team is led by Professor and IEM Director Andrew McCulloch and includes nine dynamic and innovative faculty from Bioengineering, Mechanical and Aerospace Engineering, Orthopedic Surgery and Biological Sciences including Professors Adam Engler, Stephanie Fraley, Robert Sah and Daniela Valdez-Jasso in Bioengineering, as well as our many collaborators at the other institutions including Professor Todd Coleman at Stanford. UC San Diego is home to the Multiscale Athlete moonshot and the Triton Center for Performance and Injury Science innovation hub of the alliance.
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A new BioEng assistant professor interviews Lingyan Shi, PhD about her award-winning research program.
The researchers report their findings in a paper published Mar. 10 in Science Translational Medicine and the work was highlighted by Francis Collins in the NIH Director’s Blog.
The idea for such a treatment emerged when Moreno was a Ph.D. student in UC San Diego bioengineering Professor Prashant Mali’s lab. Mali had been investigating the possibility of applying CRISPR-based gene therapy approaches to rare as well as common human diseases.
“I still don’t have an office on campus” Dr. Smarr laughs. “True story: I started at UC San Diego in the first week of March, 2020. I showed up and I said ‘where do I put my stuff.’ They told me they still needed to clean out the office I would use, so come back next week. Next week, everything shut down, so I still don’t have an office.” Benjamin Smarr was coming from Berkeley, where he’d been an NIH K99 fellow studying circadian rhythms and reproductive neuroendocrinology in rodent models. Luckily, as it would turn out, he had been transitioning from wet lab work to data science, using implanted sensors to capture physiological time series from his experimental subjects, and developing methods for extracting patterns in these time series that could predict things like pregnancy outcomes or hormonal disruptions. When COVID-19 hit, and he couldn’t find space on campus, it pushed him to complete his conversion to digital science.
By studying how different pluripotent stem cell lines build muscle, Professor Subramaniam of UC San Diego Bioengineering led a multi-site collaboration to discovered how epigenetic mechanisms can be triggered to accelerate muscle cell growth at different stages of stem cell differentiation.
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Combining ecosystem dynamics, the microbiome, metabolomics, and time series analysis make a detailed case against specific strains of E. coli as having means, opportunity, and motive.