Embedded Files
Single HCO Motif
Izhikevich HCO
Spiking behaviors of two neurons of a single HCO motif for the Izhikevich model. The parameter values for the silent mode are: I=2, a=0.02, b=0.2, c=-65 mV, d=8, Isyn=8, τsyn=40 ms; for the spiking mode, same as silent except I=8; for the asymmetric mode, same as spiking except Isyn=18; for the bursting mode, same as spiking, except I=5, c=-50 mV, d=0.5.
Morris-Lecar HCO
Spiking behaviors of two neurons of a single HCO motif for the Morris-Lecar model. The parameter values for the spiking mode are: I=0.8μA, gL=5μS, gCa=15μS, gK=20μS, gsyn=10μS, EL=-50 mV; for the asymmetric mode, same as spiking, except gK=10μS and gsyn=5μS.
Dimensional stacking of all 4,096 simulations for a single HCO motif with Morris-Lecar neuron model. The period of each HCO is color-coded according to the colormap on the right. Darker shades of blue correspond to higher periods. Each bin on the x and y axis corresponds to a range of values for each parameter.
HCO Chains
Visualizations and analyses of different topologies with the same parameters and their resulting voltage traces. As can be seen for both models, the network topology with just 2 HCOs has a drastic impact on the steady state firing activity for the Izhikevich model and the shape of the voltage trace for the Morris-Lecar model. This inter-HCO connectivity adds another parameter level to sweep through as well as the number of HCOs within the chain.
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