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Design Overview
Design Overview
Viral vectors are one of the most promising tools for gene delivery due to their efficiency and relative ease to customize. In this project, we designed a Herpes Simplex Virus 1(HSV-1) viral vector in the form of a bacterial artificial chromosome with an excisable bacterial sequence and a recombination site that allows simple insertion of the gene of sequence. The vector was engineered through recombineering methods in genetically modified E.coli. The viral vector construct allows the manipulation of its genome in bacteria and can deliver large DNA constructs of up to 100kb.
Problem Statement
Problem Statement
There is a lack of viral vectors available that can be easily engineered to deliver large DNA constructs to a wide range of hosts.
Overall objective and expected outcome of the project.
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