There are no easy or efficient means of measuring growth of physeal tissue while viewing responses to mechanical or chemical stimuli and observing changes to the tissue over time. The four most important goals of our bioreactor are accommodation, mechanical loading, chemical modulation, and visualization of the physis. Our design involves a vertical, sandwich-shaped tank within a larger tank and impermeable boundaries on the lateral edges of the physis that ensure a parabolic oxygen gradient within the slice that is mainly governed by Fick’s 2^nd Law to satisfy physiological accommodation and chemical modulation. Mechanical loading is done by a spring-loaded interface which impinges one side of the metaphyseal end of the physis and imaging of vertical slices is accomplished by using a prism that redirects the line of sight of a microscope horizontally.