Embedded Files
DEPARTMENT OF MECHANICAL AND
AEROSPACE ENGINEERING
University of California, San Diego
INSTRUCTOR
Professor Dr. Maziar Ghazinejad
TA
Peter Violante
SPONSOR
Professor Dr. Geert Schmid-Schoenbein
TRIANGULAR DESIGN GROUP
Justin Oshiro
Jiansong Wang
Avinash Laha
Aziz Moganamm
MODULAR DESIGN GROUP
Yavit Vargas
BACKGROUND
Leakage of digestive enzymes across a scarred intestinal wall can lead to inflammation and “autodigestion” of other adjacent organs in the body. Thus, it is crucial to treat the outer protective layer and help regenerate the structure of the intestine. Recent stem cell regeneration of cardiac tissue has been made possible by novel hydrogels, which also show promise in being administered in other organs like the small intestine.
SOLUTION
Inject hydrogel into the submucosa layer to stimulate stem cells to regenerate the protective tissue layer in the small intestine.
DESIGN OBJECTIVE
This solution requires a precision hydrogel injector that aids surgeons in successfully targeting and delivering a predetermined dosage of hydrogel into the mucosal stem cell region. We plan to implement a biomedical device that creates a suction mechanism to grip onto a rat intestine model and is built with an insertion tunnel that allows a hydrogel syringe to inject the fluid at the intestinal site.
Our Design Goal in Four Simple Steps!
Animation of Design Goal
Initial Prototype Design
CAD View of Initial Prototype
3D Printed Initial Prototype
3D Printed Initial Prototype
Final Prototype Design
CAD View of Final Prototype
CAD View of Final Prototype
3-D Printed Final Prototype
3-D Printed Final Prototype
See Final Design Page for Design Improvements
Experimental Results
Successful experimental tests of injecting a red-dyed aqueous solution into the submucosa layer of a rodent's small intestine.
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