Hinton Lab

Venture into understanding pseupdophosphatases roles in the protein phosphorylation signaling cascade! Protein phosphorylation signaling cascades are critical regulators of cellular responses such as growth, proliferation, differentiation, migration, and cell death. Kinases, enzymes that phosphorylate proteins, are known to control the amplitude of a signal response, whereas phosphatases, enzymes that dephosphorylate proteins, are thought to be important for controlling the rate and duration of the response. These enzymes control the activity of target proteins by coordinating a fine balance between phosphorylation and dephosphorylation. Disruption of this balance may lead to diseases such as cancer, diabetes, inflammation, dementia, and Alzheimer’s. Discovery of proteins termed pseudokinases and pseudophosphatases, which lack catalytic activity but have homology with kinases and phosphatases, has added another layer of complexity to phosphorylation cascades.

Please join us in our journey to understand the function of a pseudophosphatase termed MK-STYX by exploring the icons!