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Research in the Hinkle Lab
Research in the Hinkle Lab
We are interested in creating new reactions and studying reactive intermediates. In particular, we create novel molecules using oxocarbenium ion and iodonium ion intermediates in cascade, or domino reaction sequences. These complex processes involve a number of discreet organic transformations in which the individual reactions must take place in a specific order for the overall reaction to afford products in reasonable yields. In essence, one reaction (domino) must fall (react) before the next reaction can proceed, and so-on.
For more information on Prof. Hinkle, see the page entitled "About." To see what we're interested in studying at the present time, please visit our "Current Research and Publications" page. For older chemistry, please see the "Research Page."
Prins Chemistry
Prins Chemistry
The Prins reaction was first described 100 years ago and is the result of attack of an activated ketone or aldehyde by an alkene followed by trapping by a nucleophile. In the last two decades, it has become increasingly important in the synthesis of tetrahydropyran and dihydropyran ring systems, which are prevalent in many anticancer, antifungal and antibiotic compounds.
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Contact
Contact
Robert J. Hinkle
Vice-Dean for Natural, Physical, and Computational Sciences & Interdisciplinary Studies, Professor of Chemistry
William & Mary
Office: ISC 2043 / Ewell Hall 136
Lab: ISC 2070
(757) 221-1501
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