論文與著作

Chii-Wen Chou†, Chia-Chun Huang†, Ke-Min Chen†, Chun-I Wang†, Wan-Jing Chen, Chiung-Hung Hsu, Shih-Chan Lai, Shyun Chou, Yu-Kang Chang, Kuan-Yu Lin, Chih-Hao Chiu,  Cheng-You Lu#. Upregulation of Nrf2 attenuates Angiostrongylus cantonensis-induced parasitic meningitis in mice. Parasites & Vectors. 2025. Apr 3;18(1):129. Corresponding Author) (SCI). (2024_IF=3. /2023_IF=3.2. Rank of TROPICAL MEDICINE|Q1: 6/28=21.4% / Rank of PARASITOLOGY |Q1:11/46=23.9%)

Ke-Min Chen, Cheng-You Lu, Shih-Chan Lai#. Activation of the COX-2/mPGES-1/PGE-2 cascade through the NLRP3 inflammasome contributes to Angiostrongylus cantonensis-induced eosinophilic meningoencephalitis. Parasitology Research. 2025. Jan 20;124(1):9. (SCI) (2024_IF=1.8. /2023_IF=2. Rank of PARASITOLOGY |Q3:23/46=50%)

Pei-Fang Lai, Ramasamy Mahendran, Bruce Chi-Kang Tsai, Cheng-You Lu, Chia-Hua Kuo, Kuan-Ho Lin, Shang-Yeh Lu, Yu-Ling Wu, Yung-Ming Chang, Wei-Wen Kuo#, Chih-Yang Huang#. Calycosin Enhances Heat Shock Related-Proteins in H9c2 Cells to Modulate Survival and Apoptosis against Heat Shock. The American journal of Chinese medicine. 2024 Jun 28:1-21. (SCI) (2024_IF=4.8.  Rank of MEDICINE, GENERAL & INTERNAL|Q1: 34/325=10.46%)

An-Chih Chen*, Shih-Chan Lai*, Cheng-You Lu, Ke-Min Chen#. . Exploration of the Molecular Mechanism by Which Caveolin-1 Regulates Changes in Blood–Brain Barrier Permeability Leading to Eosinophilic Meningoencephalitis. Tropical Medicine and Infectious Disease. 2024. 9 (6), 124. (SCI) ((2024_IF=2.8. /2023_IF=2.9. Rank of TROPICAL MEDICINE|Q1: 7/28=25%)

Chi-Cheng Li, Cheng-You Lu, Chiung-Hung Hsu, Dennis Jine-Yuan Hsieh, Tso-Fu Wang, Tsung-Jung Ho, Wei-Wen Kuo, Cecilia Hsuan Day, Shih-Chieh Liao, Ming-Cheng Chen#, Chih-Yang Huang#. Calycosin inhibits gemcitabine-resistant lung cancer cells proliferation through modulation of the LDOC1/GNL3L/NFκB. The Chinese Journal of Physiology (2024-->Journal of Physiological Investigation). 2023 Jul-Aug;66(4):189-199. (SCI) (2023_IF=1.8. 81.3%) 

Cheng-You Lu, Chia-Hua Kuo, Wei-Wen Kuo, Dennis Jine-Yuan Hsieh, Tso-Fu Wang, Cheng Yen Shih, Pi-Yu Lin, Shinn-Zong Lin, Tsung-Jung Ho#, Chih-Yang Huang#. Ohwia caudata extract relieves the IL-17A-induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation. Environmental Toxicology. 2023 Aug;38(8):1914-1924. (First Author) (SCI)  (2023_IF=4.5. 21.5% ).

Chien-Yi Chiang*, Yu-Jung Lin*, Wen-Tsan Weng*, Heng-Dao Lin, Cheng-You Lu, Wan-Jing Chen, Cheng Yen Shih, Pi-Yu Lin, Shinn-Zong Lin, Tsung-Jung Ho, Marthandam Asokan Shibu, Chih-Yang Huang#. Recuperative herbal formula Jing Si maintains vasculature permeability balance, regulates inflammation and assuages concomitants of “Long-Covid”. Biomedicine & Pharmacotherapy. 2023. 163:114752. (SCI)  (2023_IF=7.5. 6.6%).

Cheng-You Lu, Ke-Min Chen, Wei-Wen Kuo, Shih-Chan Lai, Tsung-Jung Ho, Po-Tang Lai, Chih-Yang Huang#, Tso-Fu Wang#. Calycosin attenuates Angiostrongylus cantonensis-induced parasitic meningitis through modulation of HO-1 and NF-κB activation. Parasitology. 2023 Apr;150(4):311-320. (First Author) (SCI) (IF=3.243. 32.05%)

Jhong-Kuei Chen, Chia-Hua Kuo, Wei-Wen Kuo, Cecilia Hsuan Day, Tso-Fu Wang, Tsung-Jung Ho, Pi-Yu Lin, Shinn-Zong Lin, Tzu-Ching Shih, Cheng-Yen Shih, Chih-Yang Huang#, Cheng-You Lu#. Artemisia argyi extract ameliorates IL-17A-induced inflammatory response by regulation of NF-κB and Nrf2 expression in HIG-82 synoviocytes. Environ Toxicol. 2022 Nov;37(11):2793-2803. (Corresponding Author)(SCI) (IF=4.109. 28.5%)

Da-Tong Ju, Dao Van Thao, Cheng-You Lu, Ayaz Ali, Marthandam Asokan Shibu,  Ray-Jade Chen, Cecilia Hsuan Day, Tzu-Ching Shih,  Cheng-Yen Tsai, Chia-Hua Kuo, Chih-Yang Huang#. Protective effects of CHIP overexpression and Wharton's jelly mesenchymal-derived stem cell treatment against streptozotocin-induced neurotoxicity in rats. Environ Toxicol. 2022. 37(8):1979-1987. (SCI)(IF=4.109. 28.5%)

Chih-Yang Huang, Yi-Chen Su, Cheng-You Lu, Ping-Ling Chiu, Yung-Ming Chang, Da-Tong Ju, Ray-Jade Chen, V. Vijaya Padma, Tsung-Jung Ho#, Hui-Chuan Kao#. Edible folic acid and medicinal folinic acid produce cardioprotective effects in late-stage triple-transgenic Alzheimer’s disease model mice by suppressing cardiac hypertrophy and fibrosis. Environ Toxicol. 2022. 37(7):1740-1749. (SCI) (IF=4.109. 28.5%)

Cheng-You Lu, Cecilia Hsuan Day, Chia-Hua Kuo, Tso-Fu Wang, Tsung-Jung Ho, Pei-Fang Lai, Ray-Jade Chen, Chun-Hsu Yao, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang#. Calycosin alleviates H2O2-induced astrocyte injury by restricting oxidative stress through the Akt/Nrf2/HO-1 signaling pathway. Environ Toxicol . 2022. 37(4):858-867.  (SCI)(IF=4.109. 28.5%)

Cheng-You Lu, Shih-Chan Lai, Hsiu-Hsiung Lee, Hui-Tan Chien, Ke-Min Chen#. Matrix metalloproteinases activation in Toxocara canis induced pulmonary pathogenesis. Journal of Microbiology Immunology and Infection. (J Microbiol Immunol Infect). 2021 Dec;54(6):1147-1153. (SCI)(First Author) (IF=10.273. 12.13%)

Tian-Kuo Lee, Cheng-You Lu, Sheng-Tzung Tsai, Pao-Hui Tseng, Yu-Chen Lin,  Shinn-Zong Lin, Jonas C Wang, Paul R. Sanberg,  Cesar V. Borlongan, Chih-Yang Huang, Tsung-Lang Chiu. Complete Restoration of Motor Function in Acute Cerebral Stroke Treated with Allogeneic Human Umbilical Cord Blood Monocytes: Preliminary Results of A phase I Clinical Trial. Cell Transplantation (Cell Transplant). 2021. 30:9636897211067447. (SCI)(IF=4.139. 35.4%)

Marthandam Asokan Shibu, Yu-Jung Lin, Chien-Yi Chiang, Cheng-You Lu, Debakshi Goswami, Navneethan Sundar, Surbhi Agarwal, Bi-Yu Lin, Shinn-Zong Lin, Tsung-Jung Ho, Wan-Ting Tsai, Wei-Wen Kuo, Chih-Yang Huang#. Novel anti-aging herbal formulation Jing Si Herbal Drink displays pleiotropic effects against aging associated disorders. Biomedicine & Pharmacotherapy (Biomed Pharmacother). 2022. 146:112427. (SCI) (IF=7.419. 9.14%)

Hsi-Lung Hsieh*, Ching-Chung Liang*, Cheng-You Lu, Jen-Tsung Yang, Chiu-Yen Chung, Yu-Shien Ko, Tsong-Hai Lee#. Induced pluripotent stem cells can improve thrombolytic effect of low-dose rt-PA after acute carotid thrombosis in rat. Stem Cell Research & Therapy (Stem Cell Res Ther.) 2021. 12(1):549. (SCI)(IF=8.098. 12.07%)

Fu-Tzu Pai, Cheng‐You Lu, Chia-Hsin Lin, John Wang, Ming-Cheng Huang, Chuan-Teng Liu, Ying-Chyi Song, Cheng-Lung Ku#, Hung-Rong Yen#. Psoralea corylifolia L. ameliorates collagen-induced arthritis by reducing proinflammatory cytokines and upregulating myeloid-derived suppressor cells. Life (Basel). 2021. 11(6):587. (SCI) (IF=3.817. 28.5%)

Yen-Lun Kung, Cheng-You Lu, Khan Fareen Badrealam, Wei-Wen Kuo, Marthandam Asokan Shibu, Cecilia Hsuan Day, Ray-Jade Chen, Shang-Yeh Lu, Viswanadha Vijaya Padma, Chih-Yang Huang#. Cardioprotective potential of Amygdalin against Angiotensin II induced cardiac hypertrophy, oxidative stress and inflammatory responses through modulation of Nrf2 and NF-κB activation. Environ Toxicol. 2021. 36(5):926-934. (SCI)(IF=4.119. 21%)

Ling-Yuh Shyu, Ke-Min Chen, Cheng-You Lu, Shih-Chan Lai#. Regulation of Proinflammatory Enzymes by Peroxisome Proliferator–Activated Receptor Gamma in  Astroglia Infected with Toxoplasma gondii. Journal of parasitology (J Parasitol) 2020. 106(5):564-571. (SCI)

Shih-Chan Lai, Cheng-You Lu, Ling-Yuh Shyu, Ke-Min Chen#. Angiostrongylus cantonensis infection induces MMP-9 and causes tight junction proteins disruption associated with Purkinje cells degeneration. Parasitol Res. 2020. 119(10):3433-3441.

Yung-Ming Changa, Manoj-Kumar M, Cheng-You Lu, Chuan-Te Tsaic, Chin-Chuan Tsaia, Po-Hsiang Liao, Shu-Luan Lin, Chia-Cheng Changg, B-Mahalakshmi, Wei Wen Kuoi#, Chih Yang Huang#. Parkinson’s disease a futile entangle of Mankind’s credence on an herbal remedy: A review. Life Sciences (Life Sci). 2020. 257:118019. (SCI) (IF=5.037. 24.4%)

Jo-Ping Chin, Chien-Min Chen, Tsong-Hai Lee, Chii-Wen Chou, Cheng-You Lu#. Angiostrongylus cantonensis-conditioned culture medium induces myelin basic protein alterations via Erk1/2 and NF-κB activation in rat RSC 96 schwann cells. Chin J Physiol. 2018. 61:137-143. (SCI) (Corresponding Author) (IF=1.764. Q4)

Kuan-Yu Lin, Chien-Min Chen, Cheng-You Lu#, Chun-Yuan Cheng#, Yu-Hsin Wu#.  Regulation of miR-

21 expression in human melanoma via UV-ray-induced melanin pigmentation. Environ Toxicol. 2017. 

32:2064-2069. (SCI) (Co-Corresponding Author)

Chien-Min Chen , Lian Chiu, Hung-Chi Chen, Chun-Yuan Cheng, Woei-Cherng Shyu, Chii-Wen Chou, Cheng-You Lu#, Chung-Tien Lin#. Glucose transporter type 4 redistribution on the membrane induced by insulin through Akt in hydrocortisone treatment in rat skeletal muscles. Chin J Physiol. 2015. 58: 294-301. (SCI) (Co-Corresponding Author) (IF=1.764. Q4)

Ruey-Hwang Chou*, Cheng-You Lu*, Wei-Lee, Jia-Rong Fan, Yung-Luen Yu, Woei-Cherng Shyu#. The potential therapeutic applications of olfactory ensheathing cells in regenerative medicine. Cell Transplant. 2014. 23:567-71. (SCI) (Co-First Author)

Yi-Chun Lin, Kuei-Mei Cheng, Hsin-Yu Huang, Pei-Yu Chao, Jin-Ming Hwang, Hsueh-Hui Lee, Cheng-You Lu, Yung-Wei Chiu#, Jer-Yuh Liu#. Hepatoprotective activity of Chhit-Chan-Than extract powder against carbon tetrachlorideinduced liver injury in rats. J Food Drug Anal. 2014. 22:220-29. (SCI)

Wang Ming Fu, Cheng-You Lu, Shih-Chan Lai#. Up-regulation of matrix metalloproteinases-2 and -9 via an Erk1/2/NF-κB pathway in murine mast cells infected with Toxoplasma gondii. J Comp Pathol. 2013. 149:146-55. (SCI)

 Cheng-You Lu, Shih-Chan Lai#.Induction of matrix metalloproteinase-2 and -9 via Erk1/2-NF-κB pathway in human astroglia infected with Toxoplasma gondii. Acta Trop. 2013. 127:14-20. (SCI) (First Author) (IF=3.112. 15.3%)

Cheng-You Lu, Shih-Chan Lai#. Matrix metalloproteinase-2 and -9 lead to fibronectin degradation in astroglia infected with Toxoplasma gondii. Acta Trop. 2013. 125: 320-9. (SCI) (First Author) (IF=3.112. 15.3%)

Chou-Cin Shin, Chou-Min Chi, Chen-Ke Min, Cheng-You Lu, Shih-Chan Lai#. Induction of plasminogen activators in pregnant women with Toxoplasma gondii infection. Clin Exp Obstet Gyneco. 2011. 38: 342-6. (SCI)

Ke-Min Chen, Shih-Chan Lai, Chiung-Hung Hsu, Cheng-You Lu#. (2024, Nov). MiR-185-3p regulates brain injury by targeting RAGE in Angiostrongylus cantonensis-infected mic. 112學年度跨院及跨校際合作暨研究計劃成果發表會. 中山醫學大學, Taichung, Taiwan. 本人為通訊作者.

Ke-Min Chen, Cheng-You Lu, Shih-Chan Lai#. (2024, Nov). Activation of the COX-2/mPGES-1/PGE-2 cascade through the NLRP3 inflammasome contributes to Angiostrongylus cantonensis-induced eosinophilic meningoencephalitis. 112學年度跨院及跨校際合作暨研究計劃成果發表會.中山醫學大學, Taichung, Taiwan.

Yu-Heng Huang*, Chii-Wen Chou*, Ke-Min Chen, Wan-Jing Chen, Kuan-Yu Lin, Chiung-Hung Hsu, Cai-Ying Lin, Shih-Chan Lai, Cheng-You Lu# (2024, Mar). Albendazole–calycosin co-therapy could mitigates eosinophilic meningitis caused by Angiostrongylus cantonensis. 台灣寄生蟲學會第三十九次會員大會暨第三十八次學術討論會, 高雄醫學大學, Kaohsiung, Taiwan. P02. 本人為通訊作者.

Chii-Wen Chou, Chiung-Hung Hsu, Jeremy Jian Wei Chen, Jeremy Jian Wei Chen, Jin-Long Huang, Cheng-You Lu* (2022, Dec). Calycosin–albendazole co-therapy attenuates Angiostrongylus cantonensis-induced parasitic meningitis through modulation of HO-1 and NF-κB activation. 2022中興、中榮及中科舉辦新創論談與產學合作媒合會, 台中榮總, Taichung, Taiwan. 本人為通訊作者.

Chii-Wen Chou, Chiung-Hung Hsu, Jeremy Jian Wei Chen, Jeremy Jian Wei Chen, Jin-Long Huang, Cheng-You Lu* (2022, Dec). Artemisia argyi extract ameliorates IL-17A-induced inflammatory response in synoviocytes by regulation of NF-κB and Nrf2/HO-1 expression. 2022 新創論談與產學合作媒合會, 台中榮總, Taichung, Taiwan. 本人為通訊作者.

 Wan-Jing Chen*, Cheng-You Lu, Chih-Yang Huang. (2022, Dec). Low-folate status as stress factor to promote insulin resistance on type 2 diabetes mellitus by reprogramming glucose energy metabolism. Asia Pacific Nutrigenomics Nutrigenetics Organisation. APNNO 2022 BIENNIAL CONFERENCE. Taipei, Taiwan.

Marthandam-Asokan Shibu, Cheng-You Lu, Chih-Yang Huang.* (2019, Dec). CHIP overexpressing adipose-derived Mesenchymal Stem cells displaying augmented IGF1R activation as favourable transplants for better cardio-protection. 2019 Taiwan Healthcare + Expo (2019台灣醫療科技展), Taipei. 2019.12.05 ~ 2019.12.08.

 Hung-Rong Yen, Fu-Tzu Pai, Cheng-You Lu*. Inhibition of dendritic cells and Th17 cells by a flavonoid compound attenuates clinical severities in a murine collagen-induced arthritis model. J Immunol May 1, 2019 May, 202 (1 Supplement) 133.14. 華盛頓 D.C. 本人為通訊作者.

Hung-Rong Yen, Fu-Tzu Pai, Cheng-You Lu, Ying-Chyi Song, Mei-Yao Wu, Sheng-Jie Yu, Ming-Cheng Huang. CD001, an active compound from  Astragalus membranaceus, downregulates TH17 cells differentiation and attenuates collagen-induced arthritis through inhibition of IL-6/IL-6R signaling. J Immunol May 1, 2017 May, 198 (1 Supplement) 224.8，華盛頓 D.C. 

Lin, L. J, Lu, C.Y, Chen, P. Y, Shyu. W. C, Chiu, S. C, Chen, H. C.* 2016. The relationship between the viability of hypoxic jejunum and the pre-transplantation changes of cytokine-IL-1b, IL-6, and Nitric oxide. The 1st International Symposium on Biomedical Science, Taichung. ISBS-104. (第一屆生物醫學國際研討會)

 Lin, L. J, Lu, C.Y, Chen, P. Y, Shyu. W. C, Chiu, S. C, Chen, H. C.* 2016. To investigate the effect of the 

jejunum hypoxic tissue viability before  transplantation cytokine-IL-1b, IL-6, NO changes. The 31 th 

Joint Annual Conference of Biomedical Science, Taipei. P.587 (706).

 Lin, K. Yu, Shyu. W. C, Chiu. L, and Lu, C. Y.* 2015. To explore the effect of miR-21 in human melanoma A375.S2 cell from UV rays induced melanin pigmentation. The 8th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC), Hsinchu. No.: PC-9.( P.103.)(第八屆泛太平洋國際幹細胞及癌

症研究研討會)

Kao, E. S, Lu, C. Y,and Lin, K. Yu.* 2015. MiR-21 protected A375.S2 human melonamoa cells from UV rays induced melanin pigmentation. The 30 th  Joint Annual Conference of Biomedical Science, Taipei. P.306.

Lu, C. Y., Lin, T. Y., Wu, C. W., Lin, K. Y., Hsu, C. H. and Lai, S. C.* 2012. The effect of rosiglitazone treatment in astroglia response to Toxoplasma gondii. The 12th Joint Annual Conference of Taiwan Society of Health System Pharmacists. Kaohsiung, Taiwan. P. 157.

吳雀維, 盧正祐, 朱慧珍, 林政仁. 2012. 手術後給予注射Dynastat止痛是否和Ketorolac一樣安全有效. 台灣實證醫學學會（TEBMA）2012學術年會. Taichung, Taiwan. PA21.

Lu, C. Y., Li, Y. C., Lai, Z. M.,Chem, K. M. and Lai, S. C.* 2012. Fibronectin degradation by matrix metalloproteinase-2 and -9 in astroglia infected with Toxoplasma gondii. 5th Asia-Pacific Laboratory Science Forum 2012, Taichung, Taiwan. P. 93.

Li, Y. C, Lin, Cheng, D. P., Shuo, C. Y., Lu, C. Y. and Lee, M.S.* 2012. Correlation of Human follicular fluid Hedgehog contents with oocyte quality. 5th Asia-Pacific Laboratory Science Forum 2012, Taichung, Taiwan. P. 77.

王銘甫, 盧正祐, 賴世展, 2011. Fibronectin degradation by MMP-2/MMP-9 in the serum of pregnant women and umbilical cord with Toxoplasma gondii infection. 中山醫大51周年校慶學術研討會 (100學年度跨院際合作計畫成果發表會). Taichung. P. 15.

Lin, K. Yu., Chen, K. M., Lee, H. H., Lu, C. Y., Chiu, P. S. and Shih-Chan Lai.* 2011. Alterations of 2’, 3’-cyclic nucleotide 3’-phosphohydrolase and myelin proteins in inflammatory demyelination of BALB/c mice caused by Angiostrongylus cantonensis. The Twenty-Fifth Joint Annual Conference of Parasitology, Taichung. P. 27.

周邦新, 盧正祐, 賴世展, 2010. Matrix metalloproteinase-12 increase and elastin degradation in confinement pregnant women with Toxoplasma gondii infection.中山醫大50周年校慶學術研討會 (99學年度跨院際合作計畫成果發表會). Taichung. P. 08.

 Chen, K. M., Chiu, P. S., Lu, C. Y. and Lai, S. C.* 2010. Proteolytic Enzymes and Pathological Changes in Permissive and Non-permissive Animal Hosts for Angiostrongylus cantonensis Infection. The 25th Joint Annual Conference of Biomedical Science, Taipei. P. 140.

 Lu, C. Y., Chen, K. M., Lee, H. H. and Lai, S. C.* 2010. Matrix metalloproteinase-12 increase and elastin degradation in astroglia infected with Toxoplasma gondii. The Twenty-Fourth Joint Annual Conference of Parasitology, Kaohsiung. P. 29.

  Chiu, P. S., Lu, C. Y., Lee, H. H., Lan, K. P., and Lai, S. C.* 2009. Study on gel images of zymography. The Twenty-Third Joint Annual Conference of Parasitology, Taichung. P. 22.

Chen, K. M., Lu, C. Y. and Lai, S. C.* 2008. Changes to plasminogen activators and matrix metalloproteinase-9 in dogs with toxocarosis. The 23rd Joint Annual Conference of Biomedical Sciences, Taipei. P. 464.

Chang, S. F., Chen, K. M., Chiu, P. S., Lu, C. Y. and Lai, S. C.* 2005. Association of plasminogen activators and matrix metalloproteinase-9 proteolytic enzymes with blood-CNS barrier damage in angiostrongyliasis. The Twentieth Joint Annual Conference of Parasitology, Kaohsiung. P. 26

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