Publications

Original Papers

Tajiri, R., Hirano, A., Kaibara, Y., Tezuka, D., Chen, Z., Kojima, T. (2023). Notch signaling generates the “cut here line” on the cuticle of the puparium in Drosophila melanogaster. iScience 26, 107279. 10.1016/j.isci.2023.107279

Yoda, S., Sakakura, K., Kitamura, T., KonDo, Y., Sato, K., Ohnuki, R., Someya, I., Komata, S., Kojima, T., Yoshioka, S., et al. (2021). Genetic switch in UV response of mimicry-related pale-yellow colors in Batesian mimic butterfly, Papilio polytes. Sci Adv 7. 10.1126/sciadv.abd6475

Tajiri, R., Fujiwara, H., and Kojima, T. (2021). A corset function of exoskeletal ECM promotes body elongation in Drosophila. Commun Biol 4. 10.1038/s42003-020-01630-9

Natori, K., and Kojima, T. (2019). Subdivision of the Tarsal Region into Five Tarsal Segments by the Combination of Region-Specific Transcription Factors. Cytologia (Tokyo) 84, 105–105. 10.1508/cytologia.84.105

Ando, T., Fujiwara, H., and Kojima, T. (2018). The pivotal role of aristaless in development and evolution of diverse antennal morphologies in moths and butterflies. BMC Evol Biol 18, 8. 10.1186/s12862-018-1124-2

Tajiri, R., Ogawa, N., Fujiwara, H., and Kojima, T. (2017). Mechanical Control of Whole Body Shape by a Single Cuticular Protein Obstructor-E in Drosophila melanogaster. PLoS Genet 13, e1006548. 10.1371/journal.pgen.1006548

Shirai, H., Kamimura, M., Yamaguchi, J., Imanishi, S., Kojima, T., and Fujiwara, H. (2012). Two Adjacent cis-Regulatory Elements Are Required for Ecdysone Response of Ecdysone Receptor (EcR) B1 Transcription. PLoS One 7, e49348. 10.1371/journal.pone.0049348

Natori, K., Tajiri, R., Furukawa, S., and Kojima, T. (2012). Progressive tarsal patterning in the Drosophila by temporally dynamic regulation of transcription factor genes. Dev Biol 361, 450–462. 10.1016/j.ydbio.2011.10.031

Ando, T., Kojima, T., and Fujiwara, H. (2011). Dramatic changes in patterning gene expression during metamorphosis are associated with the formation of a feather-like antenna by the silk moth, Bombyx mori. Dev Biol 357, 53–63. 10.1016/j.ydbio.2011.05.672

Miyazono, K.-I., Zhi, Y., Takamura, Y., Nagata, K., Saigo, K., Kojima, T., and Tanokura, M. (2010). Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless. EMBO Journal 29. 10.1038/emboj.2010.53

Okamoto, S., Futahashi, R., Kojima, T., Mita, K., and Fujiwara, H. (2008). A catalogue of epidermal genes: genes expressed in the epidermis during larval molt of the silkworm Bombyx mori. BMC Genomics 9, 396. 10.1186/1471-2164-9-396

Sato, K., Matsunaga, T.M., Futahashi, R., Kojima, T., Mita, K., Banno, Y., and Fujiwara, H. (2008). Positional cloning of a bombyx wingless locus flugellos (fl) reveals a crucial role for fringe that is specific for wing morphogenesis. Genetics 179, 875–885. 10.1534/genetics.107.082784

Tsubota, T., Saigo, K., and Kojima, T. (2008). Hox genes regulate the same character by different strategies in each segment. Mech Dev 125, 894–905. 10.1016/j.mod.2008.06.001

Kawashima, T., Osanai, M., Futahashi, R., Kojima, T., and Fujiwara, H. (2007). A novel target-specific gene delivery system combining baculovirus and sequence-specific long interspersed nuclear elements. Virus Res 127, 49–60. 10.1016/j.virusres.2007.03.014

Okumura, T., Tajiri, R., Kojima, T., Saigo, K., and Murakami, R. (2007). GATAe-dependent and -independent expressions of genes in the differentiated endodermal midgut of Drosophila. Gene Expression Patterns 7, 178–186. 10.1016/j.modgep.2006.07.001

Sakurai, K.T., Kojima, T., Aigaki, T., and Hayashi, S. (2007). Differential control of cell affinity required for progression and refinement of cell boundary during Drosophila leg segmentation. Dev Biol 309, 126–136. 10.1016/j.ydbio.2007.07.001

Tajiri, R., Tsuji, T., Ueda, R., Saigo, K., and Kojima, T. (2007). Fate determination of Drosophila leg distal regions by trachealess and tango through repression and stimulation, respectively, of Bar homeobox gene expression in the future pretarsus and tarsus. Dev Biol 303, 461–473. 10.1016/j.ydbio.2006.11.026

Yasunaga, K., Saigo, K., and Kojima, T. (2006). Fate map of the distal portion of Drosophila proboscis as inferred from the expression and mutations of basic patterning genes. Mech Dev 123, 893–906. 10.1016/j.mod.2006.08.008

Kozu, S., Tajiri, R., Tsuji, T., Michiue, T., Saigo, K., and Kojima, T. (2006). Temporal regulation of late expression of Bar homeobox genes during Drosophila leg development by Spineless, a homolog of the mammalian dioxin receptor. Dev Biol 294, 497–508. 10.1016/j.ydbio.2006.03.015

Kojima, T., Tsuji, T., and Saigo, K. (2005). A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. Dev Biol 279, 434–445. 10.1016/j.ydbio.2004.12.005

Takahashi, M., Takahashi, F., Ui-Tei, K., Kojima, T., and Saigo, K. (2005). Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila. Development 132. 10.1242/dev.01850

Kojima, T. (2004). The mechanism of Drosophila leg development along the proximodistal axis. Dev Growth Differ 46, 115–129. 10.1111/j.1440-169X.2004.00735.x

Inaki, M., Kojima, T., Ueda, R., and Saigo, K. (2002). Requirements of high levels of Hedgehog signaling activity for medial-region cell fate determination in Drosophila legs: identification of pxb, a putative Hedgehog signaling attenuator gene repressed along the anterior–posterior compartment boundary. Mech Dev 116, 3–18. 10.1016/S0925-4773(02)00119-3

Tsuji, T., Sato, A., Hiratani, I., Taira, M., Saigo, K., and Kojima, T. (2000). Requirements of Lim1, a Drosophila LIM-homeobox gene, for normal leg and antennal development. Development 127, 4315–4323. 10.1242/dev.127.20.4315

Kojima, T., Sato, M., and Saigo, K. (2000). Formation and specification of distal leg segments in Drosophila by dual Bar homeobox genes, BarH1 and BarH2. Development 127, 769–778. 10.1242/dev.127.4.769

Sato, A., Kojima, T., Ui-Tei, K., Miyata, Y., and Saigo, K. (1999). Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants. Development 126. 10.1242/dev.126.20.4421

Orihara, M., Hosono, C., Kojima, T., and Saigo, K. (1999). Identification of engrailed promoter elements essential for interactions with a stripe enhancer in Drosophila embryos. Genes to Cells 4, 205–218. 10.1046/j.1365-2443.1999.00254.x

Sato, M., Kojima, T., Michiue, T., and Saigo, K. (1999). Bar homeobox genes are latitudinal prepattern genes in the developing Drosophila notum whose expression is regulated by the concerted functions of decapentaplegic and wingless. Development 126, 1457–1466. 10.1242/dev.126.7.1457

Hayashi, T., Kojima, T., and Saigo, K. (1998). Specification of Primary Pigment Cell and Outer Photoreceptor Fates byBarH1Homeobox Gene in the DevelopingDrosophilaEye. Dev Biol 200, 131–145. 10.1006/dbio.1998.8959

Shishido, E., Ono, N., Kojima, T., and Saigo, K. (1997). Requirements of DFR1/Heartless, a mesoderm-specific Drosophila FGF-receptor, for the formation of heart, visceral and somatic muscles, and ensheathing of longitudinal axon tracts in CNS. Development 124, 2119–2128. 10.1242/dev.124.11.2119

Takahashi, F., Endo, S., Kojima, T., and Saigo, K. (1996). Regulation of cell-cell contacts in developing Drosophila eyes by Dsrc41, a new, close relative of vertebrate c-src. Genes Dev 10, 1645–1656. 10.1101/gad.10.13.1645

Tetsuya, K., Tatsuo, M., Minako, O., and Kaoru, S. (1994). Induction of a mirror-image duplication of anterior wing structures by localized hedgehog expression in the anterior compartment of Drosophila melanogaster wing imaginal discs. Gene 148, 211–217. 10.1016/0378-1119(94)90691-2

Shigeki, T., Tatsuo, M., Shin-ichi, H., Shuhei, Z., Satoshi, I., Fumitaka, T., Minako, O., Tetsuya, K., and Kaoru, S. (1993). Structure and expression of Hedgehog, a Drosophila segment-polarity gene required for cell-cell communication. Gene 124, 183–189. 10.1016/0378-1119(93)90392-G

Higashijima, S., Kojima, T., Michiue, T., Ishimaru, S., Emori, Y., and Saigo, K. (1992). Dual Bar homeo box genes of Drosophila required in two photoreceptor cells, R1 and R6, and primary pigment cells for normal eye development. Genes Dev 6, 50–60. 10.1101/gad.6.1.50

Kojima, T., Sone, M., Michiue, T., and Saigo, K. (1993). Mechanism of induction ofBar-like eye malformation by transient overexpression ofBar homeobox genes inDrosophila melanogaster. Genetica 88, 85–91. 10.1007/BF02424465

Kojima, T., Ishimaru, S., Higashijima, S., Takayama, E., Akimaru, H., Sone, M., Emori, Y., and Saigo, K. (1991). Identification of a different-type homeobox gene, BarH1, possibly causing Bar (B) and Om(1D) mutations in Drosophila. Proceedings of the National Academy of Sciences 88, 4343–4347. 10.1073/pnas.88.10.4343

Reviews

Kojima, T. (2017). Developmental mechanism of the tarsus in insect legs. Curr Opin Insect Sci 19, 36–42. 10.1016/j.cois.2016.11.002

Kojima, T. (2017). Proximodistal Development of the Leg in Drosophila – Creation of New Developmental Fields by Gene Regulatory Interaction and Tissue Growth –. Proc. Arthropod. Embryol. Soc. Jpn. 48, 1–11

Kojima, T. (2004). The mechanism of Drosophila leg development along the proximodistal axis. Dev Growth Differ 46, 115–129. 10.1111/j.1440-169X.2004.00735.x

小嶋徹也 (2006).「発生過程における組織の厳密な領域化のメカニズム－ショウジョウバエ成虫肢形成過程における解析－」蛋白質核酸酵素　51, 256-261.

小嶋徹也 (2005).「ショウジョウバエにおけるゲノム情報を用いた発生・分化研究－遺伝子レベルでの完全な理解へ向けて－」実験医学　23, 164-168.

小嶋徹也 (2001).「ショウジョウバエの肢形成の分子メカニズム」医学のあゆみ　199, 1031-1034.

小嶋徹也，西郷薫 (1995).「ショウジョウバエヘッジホッグ遺伝子のクローニング」実験医学　13, 20-25.

小嶋徹也，西郷薫 (1991).「ショウジョウバエ複眼の形成」実験医学　9, 152-158.