The desire of the community to have a secondary school in their municipality became a reality when in the school year 1989-1990, the DECS Regional Office through the Regional Director granted a Municipal Resolution of the municipality of Sta. Praxedes, Cagayan requesting an establishment of a secondary school. The regional Director then directed the Claveria Rural and Vocational School located in the nearby municipality of Claveria, Cagayan to put up extension classes in the municipality of Sta. Praxedes, Cagayan. These extension classes were then administered and supervised in available classrooms at the Sta. Praxedes Central School.

The following year, Hon. Congressman Leoncio M. Puzon sponsored the passing of his House Bill No. 836 which finally in the year 1991 became Republic Act No. 7022, an act establishing the creation of Sta. Praxedes High School. Thus, this institution had evolved from the Claveria Rural and Vocational School-Extension Classes.

Sta. Praxedes High School is located in a peaceful municipality of Barangay Centro 1, Sta. Praxedes, Cagayan. The school is situated in one of the towns, which belongs to the second Congressional district of the Province of Cagayan. The location of the school is 150 meters away from the municipal hall and is far from any disturbance during class hours. It also allows convenient commuting of teachers and students who are living in nearby municipalities as well as resident teachers and students.

The school area is exactly 20,000 square meters, slightly rolling and a greater portion of it is still a forested area. The school has a total of 346 students. The major dialect spoken by the students is Ilocano, although there are few students who speak Tagalog. And Yapayao. Students of SPHS hail mainly from Sta. Praxedes. About 30% of the student’s population comes from nearby towns like Claveria. There are also students coming from Fuga and Calayan Island, and others come from Tanglagan, Apayao.

As the only Secondary school in the municipality, Sta. Praxedes High School is experiencing problems such as inadequate seats, comfort rooms, textbooks, laboratories including its equipment and facilities.

Sta. Praxedes High School is managed by a Principal II, has 1 Head teacher III to man the fifteen (15) Junior High School teaching staff, six (6) Senior High School teachers, 1 Administrative Assistant II and 1 Administrative Aid I of the school.

Despite the many obstacles faced by the school, smooth operation is ensured through the effective teamwork of the teaching staff and the overflowing support of both its external and internal stakeholders.