Located at Barangay Mantuyop, Siaton, Negros Oriental resting in a plain along the Dumaguete South Road highway. Siaton Science HS serves the people of the whole municipality of Siaton from barangay Siit to the West and barangay Bonawon to the East. Senior High School offering is exclusive to one Academic Track particularly Science, Technology, Engineering, and Mathematics (STEM) Strand.