Mayor Simplicio Manalo National High School is located at E. Quiogue St., Barangay Aguho, Pateros Metro Manila. It has an area of about Two Thousand Ninety Six (2,096) square meters lot donated by Late Col. Agripino Manalo in memory of their father who has been also the Mayor of Pateros, the respected late Agripino Manalo. This is also the very reason that the name of this school was being named after him.