Previously, polygonal meshes were created using Amira, a program that allows for segmentation of histological stacks. This method created 3D models manually. However, SyGlass interprets 2D stacks as volumetric data generating a comprehensive model. Visualizing the model in VR allows for a better understanding of biological structures.
Using the 2D stack of images as described on the left, SyGlass generates a 3D model. This model drastically alters the perception of the stack. The viewer can now better appreciate the ultra structure of the capillary. SyGlass has the ability to measure, trace, count, and perform many other functions to improve the empirical study of histology.
SyGlass is available at the Tenzer Center, a collaborative space where all students can gain experience working with various technologies. Virtual reality has opened a new realm of understanding in biology. Textbook images are helpful, however, being able to manipulate a model with your hands provides a completely new appreciation for the morphology of a structure. SyGlass is intuitive and specifically designed to create videos from models. This software has many potential applications, including the study of human anatomy in 3D.
An exploration into the atrium, through the atrioventricular valve and out the ventricle.
Sectioning through a blood vessel using SyGlass's cutplane tool.
Whole block model of zebrafish cardiac tissue.
Courtesy of SyGlass's sample data set, MRI data of a male's torso.