Esophageal Cancer Treatment Pipeline Analysis 2025

According to DelveInsight's evaluation, globally, the Esophageal Cancer pipeline comprises over 80 key pharmaceutical firms continuously advancing more than 100 Esophageal Cancer treatment therapies, with analysis of Clinical Trials, Therapeutics, Mechanism of Action, Route of Administration, and Developments conducted by DelveInsight.

"Esophageal Cancer Pipeline Analysis, 2025" report by DelveInsight outlines comprehensive intelligence into the current clinical development scenario and growth prospects across the Esophageal Cancer Market.

The Esophageal Cancer Pipeline analysis encompasses in-depth commercial and clinical evaluation of the pipeline products from the preclinical developmental phase to the marketed phase. The analysis also covers a comprehensive description of the medication, including the mechanism of action of the therapeutic, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.

Primary Highlights from the Esophageal Cancer Pipeline Analysis 

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• Pharmaceutical firms across the globe are diligently advancing toward developing novel Esophageal Cancer treatment therapies with a considerable amount of success over recent years.

• Esophageal Cancer pharmaceutical firms operating in the treatment market include Coherus Oncology, Inc., Iksuda Therapeutics Ltd, Akeso Biopharma, Sumit Therapeuics, Shanghai Henlius Biotech, Roche, Beijing Konruns Pharmaceutical Co., Ltd, Astellas Pharma, BeOne, among others, are creating therapies for Esophageal Cancer management.

• Emerging Esophageal Cancer investigational medications in the different phases of clinical trials include CHS-114, IKS014, Ivonescimab, HLX43, Atezolizumab, KC1036, Zolbetuximab, TEVIMBRA, among others, are anticipated to have a significant impact on the Esophageal Cancer market in the forthcoming years.

• In October 2025, Astellas Pharma Canada Inc. revealed that VYLOY(R) (zolbetuximab) was funded by the Ontario Drug Benefit Program under the New Drug Funding Program and in Quebec through the Liste des médicaments - Établissements de la RAMQ. VYLOY was funded as a first-line treatment for adult patients with locally advanced unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric or gastroesophageal junction (GEJ) adenocarcinoma whose tumours were claudin (CLDN) 18.2 positive as determined by a validated test in both provinces.

• In July 2025, Iksuda Therapeutics disclosed that the US Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for IKS014, a human epidermal growth factor receptor 2 (HER2) ADC targeting patients with advanced HER2+ solid tumours, enabling the expansion of ongoing clinical trials.

Esophageal Cancer Background

Esophageal cancer is a type of malignancy that forms in the tissues of the esophagus, the muscular tube that transports food and liquids from the mouth to the stomach. The two main types of esophageal cancer are squamous cell carcinoma, which emerges in the cells lining the esophagus, and adenocarcinoma, which often develops in the lower portion of the esophagus near the stomach. Risk factors include smoking, heavy alcohol consumption, obesity, and gastroesophageal reflux disease (GERD). Symptoms may encompass difficulty swallowing, chest pain, unexplained weight loss, and persistent heartburn. Early detection is crucial, and treatment options include surgery, radiation, chemotherapy, and targeted therapy, depending on the cancer's stage.

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Emerging Esophageal Cancer Investigational Medications Under Different Phases of Clinical Development Include:

• CHS-114: Coherus Oncology, Inc.

• IKS014: Iksuda Therapeutics Ltd

• Ivonescimab: Akeso Biopharma/Sumit Therapeuics

• HLX43: Shanghai Henlius Biotech

• Atezolizumab: Roche

• KC1036: Beijing Konruns Pharmaceutical Co., Ltd

• Zolbetuximab: Astellas Pharma

• TEVIMBRA: BeOne

Esophageal Cancer Administration Method

The Esophageal Cancer pipeline analysis presents therapeutic evaluation of the pipeline medications by Administration Method. Products are classified under various administration routes, such as:

• Intra-articular

• Intraocular

• Intrathecal

• Intravenous

• Ophthalmic

• Oral

• Parenteral

• Subcutaneous

• Topical

• Transdermal

Esophageal Cancer Molecular Classification

Esophageal Cancer products are classified under various molecular categories, such as:

• Oligonucleotide

• Peptide

• Small molecule

Esophageal Cancer Pipeline Therapeutics Evaluation

• Esophageal Cancer Evaluation by Product Category

• Esophageal Cancer By Stage and Product Category

• Esophageal Cancer Evaluation by Administration Method

• Esophageal Cancer By Stage and Administration Method

• Esophageal Cancer Evaluation by Molecular Classification

• Esophageal Cancer by Stage and Molecular Classification

DelveInsight's Esophageal Cancer Analysis covers approximately 100+ products under different phases of clinical development including:

• Late-phase products (Phase III)

• Mid-phase products (Phase II)

• Early-phase product (Phase I)

• Preclinical and Discovery stage candidates

• Discontinued & Inactive candidates

• Administration Method

Further Esophageal Cancer product details are provided in the analysis. Access the Esophageal Cancer pipeline analysis to learn more about the emerging Esophageal Cancer therapies https://www.delveinsight.com/sample-request/esophageal-cancer-pipeline-insight?utm_source=sites&utm_medium=promotion&utm_campaign=kkpr

Major Pharmaceutical Firms in the Esophageal Cancer Therapeutics Market Include:

Key pharmaceutical firms developing therapies for Esophageal Cancer include Novartis Pharmaceuticals, Sanofi, Seagen Inc., Rapa Therapeutics LLC, Incyte Corporation, Atreca, Inc., Exelixis, Bayer, BeiGene, Lyell Immunopharma, Sichuan Baili Pharmaceutical, AP Biosciences., Leap Therapeutics, Inc., Adlai Nortye Biopharma Co., Ltd., Athenex, Inc., Pfizer, Genentech, Hangzhou Neoantigen Therapeutics, Janssen Pharmaceutical, Curis, Inc., Merck KGaA, Apexigen, Inc, Shenzhen Hornetcorn Bio-technology Company, LTD, MacroGenics, Bristol-Myers Squibb, Integral Molecular, CARTEXELL, EMD Serono, among others.

Esophageal Cancer Pipeline Analysis:

The Esophageal Cancer pipeline analysis offers intelligence into:

• The analysis delivers detailed intelligence regarding pharmaceutical companies developing therapeutics for Esophageal Cancer management, including cumulative therapies created by each organization for this indication.

• It evaluates various therapeutic candidates categorized into early-phase, mid-phase, and late-phase development for Esophageal Cancer Treatment.

• Esophageal Cancer key pharmaceutical firms engaged in targeted therapeutic development with corresponding active and inactive (dormant or terminated) initiatives.

• Esophageal Cancer investigational medications classified by developmental phase, administration method, target receptor, monotherapy or combination therapy, distinct mechanism of action, and molecular classification.

• Comprehensive analysis of partnerships (company-to-company collaborations and company-to-academia partnerships), licensing arrangements, and funding particulars for future progression of the Esophageal Cancer market.

The analysis is constructed using data and information traced from the researcher's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, among others.

Access Sample PDF Report to learn more about Esophageal Cancer medications and therapies https://www.delveinsight.com/sample-request/esophageal-cancer-pipeline-insight?utm_source=sites&utm_medium=promotion&utm_campaign=kkpr

Esophageal Cancer Pipeline Market Drivers

• Increase in the number of cases of Esophageal Cancer, increasing research and development and launches of novel products by key players are some of the important factors that are fueling the Esophageal Cancer Market.

Esophageal Cancer Pipeline Market Obstacles

• However, high cost of therapy for managing esophageal cancer, side effects associated with the current treatment options and other factors are creating obstacles in the Esophageal Cancer Market growth.

Scope of Esophageal Cancer Pipeline Drug Intelligence

• Coverage: Global

• Key Esophageal Cancer Pharmaceutical Firms: Coherus Oncology, Inc., Iksuda Therapeutics Ltd, Akeso Biopharma, Sumit Therapeuics, Shanghai Henlius Biotech, Roche, Beijing Konruns Pharmaceutical Co., Ltd, Astellas Pharma, BeOne, among others

• Key Esophageal Cancer Investigational Treatments: CHS-114, IKS014, Ivonescimab, HLX43, Atezolizumab, KC1036, Zolbetuximab, TEVIMBRA, among others

• Esophageal Cancer Therapeutic Evaluation: Esophageal Cancer current marketed and Esophageal Cancer emerging therapies

• Esophageal Cancer Market Dynamics: Esophageal Cancer market drivers and Esophageal Cancer market obstacles

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate business growth and overcome challenges with a practical approach.

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