Known as hemophilia the royal disease, hemophilia is a rare genetic condition that prevents the blood from clotting properly. Individuals with this disorder experience prolonged bleeding, even from small injuries. The condition became widely recognized during the reign of Queen Victoria, whose descendants carried the disorder throughout European royal families, cementing its place in medical and historical literature.
Hemophilia is passed down through families via X-linked inheritance. This means the faulty gene resides on the X chromosome. Since males only inherit one X chromosome, they are more likely to develop the disease. Females, with two X chromosomes, are often carriers and may only show mild symptoms.
The most common forms of the disorder are types are hemophilia A and hemophilia B. Hemophilia A results from a deficiency in clotting factor VIII, whereas hemophilia B is caused by a lack of factor IX. Other rare types exist, like hemophilia C, but they are less common and continue to be studied through specialized research.
Ongoing advancements in medicine offer promising results for managing and potentially curing this condition. The biotechnology company AstraZeneca is one of the key players focusing on treatments that may benefit both male and female patients. Emerging therapies—particularly in gene editing—are opening doors to long-term solutions for people living with hemophilia.
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