Embedded Files
Current research interests:
Current research interests:
Over the past 30 years, transition metal compounds have shown great medicinal promise because of their diverse structures, chemical stability, and electronic tunability. One such complex is cis-platin (Figure 1).
Cis-platin is used extensively to combat many forms of cancer and in particular, it has been used to fight testicular cancer with a 95% survival rate. Unfortunately, this therapeutic, like many others, has severe side effects including hair loss, nausea, and the loss of taste. These problems arise because the drug attacks both healthy and cancerous cells.
Recent studies have shown that cancer cells have an over expression of folate receptors. As a result, folic acid (Figure 2) is preferentially taken up by cancerous cells, and hence, this moiety may be used to selectively target tumors while leaving the health cells alone.
For the past several years, the Krogstad research group has extensively examined the water-soluble phosphine 1,3,5-triaza-7-phosphaadamantane (PTA, Figure 3), its derivatives, and their metal complexes.
This summer, we plan to prepare new folic acid derivatives of PTA and to coordinate the water-soluble phosphines to Ru and Pt precursors. It is hoped that the resulting Pt and Ru compounds (Figure 4) will selectively target cancerous cells, and therefore have limited side effects for the patient.
This will involve utilizing synthetic methodologies from both organic and inorganic chemistry.
Publications
Publications
RECENT PUBLICATIONS (undergraduate co-authors are underlined)
Lee, W. C.; Sears, J. M.; Eads, K.; Krogstad, D. A.; Frost, B. J. “Hemilabile b-Aminophosphine Ligands Derived from 1,3,5-triaza-7-phosphadamantane (PTA): Application to Aqueous Ruthenium Catalyzed Nitrile Hydration.” Inorg. Chem. 2013, 54, 1737-1746.
Gonsalvi, L.; Guerriero, A.; Hapiot, F.; Krogstad, D. A.; Monflier, E.; Reginato, G.; Peruzzini, M. “Lower and Upper Rim-Modified PTA Derivatives: Coordination Chemistry and Applications in Catalytic Reactions in Water. Pure Appl. Chem. 2013, 85, 385-396.
Krogstad, D. A.; Guerriero, A.; Ienco, A.; Manca, G.; Peruzzini, M.; Reginato, G.; Gonsalvi, L. “Imidazolyl-PTA Derivatives as Water-Soluble (P,N) Lignds for Ruthenium-Catalyzed Hydrogenations. Organometallics 2011, 30, 6292-6302.
Guerriero, A.; Erlandsson, M.; Ienco, A.; Krogstad, D. A.; Peruzzini, M.; Reginato, G.; Gonsalvi, L. “Iridium (I) Complexes of Upper Rim Functiaonalized PTA Derivatives. Synthesis, Characterization, and Use in Catalytic Hydrogenations (PTA = 1,3,5-Triaza-7-phosphaadamantane). Organometallics 2011, 30, 1874-1884.
Krogstad, D. A.; Gohmann, K. E.; Sunderland, T. L.; Geis, A. E.; Bergamini, P.; Marvelli, L.; Young, V. G., Jr. “Preparation, Spectroscopy, X-ray analysis, and water-solubility studies of the first bis-PTA (PTA = 1,3,5-triaza-7-phosphaadamantane) derivatives.” Inorg. Chim. Acta 2009, 362, 3049-3055.
Krogstad, D. A.; Ellis, G. S.; Gunderson, A. K.; Hammrich, A. J.; Rudolf, J.W.; Halfen, J. A. “Two New Water-Soluble Derivatives of 1,3,5-triaza-7-phosphaadamantane (PTA). Synthesis, Characterization, X-ray Analysis and Solubility Studies of 3,7-diformyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane and 1-pyridylmethyl-3,5-diaza-1-azonia-7-phosphatricyclo[3.3.1.1]decane bromide.” Polyhedron 2007, 26, 4093-4100.
Krogstad, D. A.; Cho, J.; DeBoer, A. J.; Klitzke, J. A.; Sanow, W. R.; Williams, H. A.; and Halfen, J. A. “Platinum(II) and palladium (II) 1,3,5-triaza-7-phosphaadamantante (PTA) complexes as intramolecular hydroamination catalysts in aqueous and organic media.” Inorg. Chim. Acta 2006, 359, 136-147.
Krogstad, D. A.; DeBoer, A. J.; Ortmeier, W. J.; Rudolf, J. W.; and Halfen, J. A. “1,3,5-Triaza-7-phosphaadamantane (PTA) ligated iridium (I) complexes as catalysts for the intramolecular hydroamination of 4-pentyn-1-amine in water.” Inorg. Chem. Comm.2005, 8,1141-1144.
Krogstad, D. A.; Owens, S.B.; Halfen, J. A.; and Young, V. G., Jr. “Intramolecular hydroamination of alkynylamines in aqueous media catalyzed by platinum (II) 1,3,5-triaza-7-phosphaadamantane (PTA) complexes.” Inorg. Chem. Comm. 2005, 8, 65-69.
Krogstad, D. A.; Halfen, J. A.; Terry, T. J.; Young, V. G., Jr. “Synthesis and Characterization of Iridium 1,3,5-Triaza-7-phosphaadamantane (PTA) Complexes. X-ray Crystal and Molecular Structures of [Ir(PTA)4(CO)]Cl and [Ir(PTAH)3(PTAH2)(H)2]Cl6.” Inorg. Chem. 2001, 40, 463-471.
Curriculum vitae
Curriculum vitae
Contact information
Contact information
Email: krogstad@cord.edu
Phone: 218-299-4315
Office: ISC 329
Mailing address: Chemistry Department, Concordia College, Moorhead, MN 56562
Page updated
Report abuse