Inaugural GroPro Meeting 2025

Sunday 11 August 2024

Opening

• Chair: Sebastian Neggers (Netherlands)

• 16.00-17.00 Opening plenary: Shlomo Melmed (US)

“GroPro - What’s in a Name”

• 17.00-18.00 Datablitz1

• 19.00-19.30 Viewing posters: drinks may be purchased at the bar

• 19.30-21.00 Dinner

Monday 12 August 2024

• 07.30-09.00 Breakfast

Topic 1: Axes Dysregulation

• Co-chairs: Dave Grattan (New Zealand) and Sarah Hosking (Australia)

• 09.00-09.40 Plenary: Sally Camper (US)

“Genetics of Hypopituitarism: Gene Discovery in Mice”

• 09.40-10.05 Adrian Daly (Belgium)

“X-linked Acrogigantism: A Tall Tale of TADs”

• 10.05-10.30 Anthony Heaney (US)

“Cabergoline Targets Multiple Pathways to Inhibit PRL Secretion and Increase Stromal Fibrosis”

• 10.00-10.45 Amanda KE Hornsby (UK)

“Continuous Feeding Fails to Suppress Ghrelin Secretion in Human Volunteers, Resulting in Reduced Growth Hormone Pulsatility”

• 10.45-11.05 Coffee

• 11.05-11.20 Arne Hinrichs (Germany)

“Introducing the Göttingen Micropig”

• 11.20-11.45 Wouter de Herder (Netherlands)

“History of Acromegaly and Giantism”

• 11.45-12.10 Peter Trainer (UK/USA)

“An Oral SST2 Agonist for Acromegaly”

• 12.10-13.40 Lunch

Topic 2: Regulation of Physiology - Brain

• Co-chairs: Marika Charalambous (UK) and Isadora Clivatti Furigo (UK)

• 13.40-14.05 Sharon Ladyman (New Zealand)

“Prolactin Regulation of Body Temperature During Pregnancy”

• 14.05-14.30 Yazmín Macotela (Mexico)

“Beneficial Metabolic Actions of Prolactin: Novel Targets”

• 14.30-14.55 Marianna Sadagurski (US)

“Molecular and Spatial Signatures of Mouse Brain Aging: The Impact of Growth Hormone and Environmental Stressors”

• 14.55-15.15 Coffee

• 15.15-15.30 Biplob Saikia (Germany)

“Emergence of a Prolactin-Sensitive Blood Circulatory System in The Postnatal and Adult Murine Brain”

• 15.30-15.45 Risha Amarsi (UK)

“Single-Cell RNA Sequencing of the Maternal Hypothalamus Reveals a Distinct Neuroendocrine Transcriptome in Pregnancy”

• 15.45-16.10 Rosie Brown (New Zealand)

“The Interplay Between Prolactin and Dopamine to Motivate Mums to Nurture Offspring”

• 16.10-17.10 Datablitz 2

• 17.10-19.00 Viewing posters: drinks may be purchased at the bar

• 19.00-20.30 Dinner

Tuesday 13 August 2024

• 07.30-09.00 Breakfast

Topic 3: Regulation of Physiology - Peripheral Actions

• Co-chairs: Ameae Walker (US) and Jonathan Young (US)

• 09.00-09.40 Plenary: Darlene Berryman (US)

“GH: An Old Hormone with New Tricks”

• 09.40-10.05 Jason Breves (US)

“Growth Hormone and Prolactin Mediate Critical Life-History Transitions in Salmon”

• 10.05-10.30 Jose Donato (Brazil)

“The Role of Growth Hormone in Restoring Homeostasis in Situations of Metabolic Stress”

• 10.30-10.45 Fadil M. Hannan (UK)

“Prolactin Influences the Timing of Human Secretory Activation”

• 10.45-11.05 Coffee

• 11.05-11.20 Carlos Martínez-Moreno (Mexico)

“Growth Hormone (GH) Treatment is Neuroprotective and Preserves Retinal Function After an Optic Nerve Crush in Male Rats”

• 11.20-11.35 Vera Chesnakova (US)

“Local GH is a Microenvironmental Aging Landscape Determinant”

• 11.35-12.00 Andre Seale (US)

“Adaptive Responses of Prolactin to Environmental Challenges in a Euryhaline Fish Model”

• 12.00-12.25 Enzo Lalli (France)

“Prolactin: A New Adrenocorticopic Hormone?”

• 12.25-14.00 Lunch

• 14.00-18.00 Optional visit to Stirling Castle

• 18.00-19.00 Dinner

Topic 4: Pathophysiology

• Co-chairs: Mai Christiansen Arlien-Søborg (Denmark) and Carol Huang (US)

• 19.00-19.25 Laura Dichtel (US)

“The Impact of GH on Metabolic Dysfunction-AssociatedSteatotic Liver Disease (MASLD): Insights and Mechanisms”

• 19.25-19.50 Jens Otto Jørgensen (Denmark)

“Growth Hormone and Collagen Turnover in Human Models”

• 19.50-20.05 Yue Wang (NZ)

“Growth Hormone Receptor Antagonism Delays Tumour GrowthWhen Combined with Radiation in a Lung Cancer Xenograft Model”

• 20.05-20.20 Alma Lorena Perez (Mexico)

“The Vasoinhibin Analog VIAN-C4551 Reduces Melanoma Metastasis in Mice by Inhibiting Pulmonary Vascular Permeability”

• 20.20-20.50 Drinks break: drinks may be purchased from the bar

• 20.50-21.15 Shoshona Yakar (US)

“Skeletal Changes in Response to Age-Induced Somatopause”

• 21.15-21.40 Shouan Zhu (US)

“Excessive Growth Hormone Promotes Joint Degeneration and Chondrocyte Metabolic Dysfunction in Mice”

Wednesday 14 August 2024

• 07.30-09.00 Breakfast

Topic 5: Pituitary Gland Biology

• Co-chairs: Gwen Childs (US) and Tatiana Fiordelisio (Mexico)

• 09.00-09.40 Plenary: Patrice Mollard (France)

“The Hidden Face of GH Secretion”

• 09.40-10.05 Buffy Ellsworth (US)

“Molecular Mechanisms Underlying Somatotrope Differentiation and Function”

• 10.05-10.30 Konstantin Khetchoumian (Canada)

“Corticotrope-Somatotrope Interaction Directs Tissue Architecture and Size”

• 10.30-10.45 Maria Perez Milan (Argentina)

"The Nuclear Factor One B (NFI-B) Interacts with PROP1 and Regulates Pituitary Stem Cell Biology”

• 10.45-11.05 Coffee

• 11.05-11.20 Genevieve Fernandez (Israel)

“Novel Transgenic Tools for Studying the Regulation of GH in Fish”

• 11.20-11.45 Domingo Tortonese (UK)

“Pituitary Angiogenic Mechanisms Underlying the Photoperiodic Control of Prolactin Secretion”

• 11.45-12.10 Patrizio Caturegli (US)

“Isolated Hypo-Prolactinemia: The Rarest of the Rare?”

• 12.10-13.20 Lunch

Topic 6: Hormone Regulation and Feedback

• Co-chairs: Rebecca Dumbell (UK) and Tiffany Miles (US)

• 13.20-13.45 Jimena Ferraris (Sweden)

“TIDA Neurons Plasticity: From Endocrine Control to Network Connectivity"

• 13.45-14.10 Chunmei Wang (US)

“A New Perspective of Estrogenic Effects on PRL Homeostasis”

• 14.10-14.35 Tim Wells (UK)

“Eat Less to Grow More: The Impact of Meal-Feeding on the GH Axis”

• 14.35-14.40 Joe Yip (NZ)

“Reconfiguration of the Tuberoinfundibular Dopaminergic Neuronal Network in Lactating Rats”

• 14.40-14.55 Su Young Han (UK)

“Profiling of Growth Hormone-Releasing Hormone Neuron Activity in Freely Behaving Male and Female Mice”

• 14.55-15.15 Coffee

• 15.15-15.40 Agnes Martin (France)

“Physiological Modulation of Prolactin Secretion: Sex-Specific and Temporal Plasticity of TIDA Neurons Networking”

• 15.40-16.05 David Lyons (UK)

“TIDA Neurons – Cellular and Circuit Mechanisms of Neuroendocrine Control”

• 16.05-16.30 Raphael Szawka (Brazil)

“Modification of Anxiety and Stress Axis Function by Prolactin”

• 16.30-18.00 Business meeting

• 19.00-22.00 Conference Dinner

Thursday 15 August 2024

• 07.30-09.00 Breakfast

Topic 7: Prolactin and GH Receptor Function and Targeting

• Co-chairs: John Kopchick (US) and Ed List (US)

• 09.00-09.40 Plenary: Birthe Kragelund (Denmark)

"Structural Disorder in the GroPro Landscape – Why Bother?”

• 09.40-10.05 David Waxman (US)

“Sex-Dependence of STAT5-Dependent GH Signaling to the Liver Epigenome”

• 10.05-10.30 Maïté Verreault (France)

“Development of a Growth Hormone Receptor Inhibitor for Glioblastoma Treatment”

• 10.30-10.45 Reetobrata Basu (US)

“Novel Classes of Growth Hormone Antagonists Markedly Improve Response to Therapy in Human Cancers”

• 10.45-11.05 Coffee

• 11.05-11.20 Christopher M. Walsh (US)

“Growth Hormone Signaling Alters Lymphatic Pumping Rate and Lymphatic Vessel Healing”

• 11.20-11.45 Carrie Shemanko (Canada)

“Stopping the Vicious Cycle of Prolactin-Accelerated Breast Cancer Bone Metastasis”

• 11.45-12.10 Vincent Goffin (France)

“STAT5 Signaling in Benign Prostate Hyperplasia”

• 12.10-12.35 Jo Perry (New Zealand)

“Current and New Approaches to Target Growth Hormone Signaling in Cancer”

• 12.35-12.40 Close Meeting, Any Other Comments