Papers Published

• "Effect of the Novel Myotrope Danicamtiv on Cross-Bridge Behavior in Human Myocardium"  is published in the Journal of the American Heart Association, October 2023

• "Torsional and strain dysfunction precede overt heart failure in a mouse model of dilated cardiomyopathy pathogenesis" is published in the American Journal  of Physiology-Heart and Circulatory Physiology, August 2023

• "Basic science methods for the characterization of variants of uncertain significance in hypertrophic cardiomyopathy" is published in Frontiers Cardiovascular Medicine, July 2023

•  "The contribution of N-terminal truncated cMyBPC to in vivo cardiac function" is published in the Journal of General Physiology, April 2023

Grants Awarded

• Lexi is awarded the Institutional Network Award for Promoting Kidney, Urologic, & Hematologic Research Training, 06/01/2023 – 05/31/2025

• Roger is awarded the AHA Research Supplement to Promote Diversity in Science, 04/01/2023 - 03/31/2025 

Congratulations to...

• Josh for passing his qualifying exam to advance to PhD candidacy, November 2023

• Katie for entering the PhD phase of the Medical Scientist Training Program, May 2023

• Katie for giving an oral platform presentation at the Biophysical Society Meeting in San Diego, CA, February 2024

Welcome

• Welcome Alexandra Schmidt, Postdoctoral Fellow from the University of Pittsburgh

Papers Published

• "Molecular characterization of linker and loop-mediated structural modulation and hinge motion in the C4-C5 domains of cMyBPC " is published in the Journal of Structural Biology, June 2022

• "Identification of Phosphorylation and Other Post-Translational Modifications in the Central C4C5 Domains of Murine Cardiac Myosin Binding Protein C" is published
  in the ACS Omega, April 2022

Grants Awarded

• American Heart Association, 2022TPA961478, 07/01/2022 – 06/30/2025

Congratulations to...

• Josh and Katie for presenting posters at the Myofilament Meeting in Madison, WI, May 2022

Welcome

• Welcome Rogelio Gonzalez Gonzalez, Postdoctoral Fellow from the Universidad a Autonoma de San Luis Potosi, Mexico 2022-Present

• Welcome Joo-Hee Choi, Postdoctoral Researcher from Jeonbuk National University, South Korea, 2022-2024

• Welcome Mandeep Singh, Research Associate, 2022-Present

Papers Published

• "cMyBPC phosphorylation modulates the effect of omecamtiv mecarbil on myocardial force generation " is published in the Journal of General Physiology, March 2021

Grants Awarded

• NIH, R01 HL153236, 04/01/2021 – 03/31/2025

• StrideBio Inc., 11/01/2021 – 12/31/2022

Congratulations to...

• Katie for entering medical school at CWRU, July 2021

• John graduates from CWRU with an MD, and moves to Vanderbilt to enter the Physician Scientist Training Program for Internal Medicine residency, postdoctoral research fellowship, and clinical cardiology fellowship. 

Welcome

• Michael Majcher, Postdoctoral Researcher, Department of Engineering, McMaster University, Hamilton, CA, 2021 – 2022.

Papers Published

• "AAV9 gene transfer of cMyBPC N-terminal domains ameliorates cardiomyopathy in cMyBPC-deficient mice" is published in the Journal of Clinical Investigation – Insight, August 2020

• "Prof. Cristobal dos Remedios and the Sydney Heart Bank: enabling translatable heart failure research" is published in Biophysical Reviews, June 2020

• "Strategies for targeting the sarcomere; avenues for novel drug discovery" is published in Expert Opinion On Drug Discovery, April 2020

Grants Awarded

• NIH, R01 HL146676, 04/1/2019 – 03/31/2023, NCE 03/31/2024

Congratulations to...

• Yoon for entering medical school at CWRU, July 2020

• Josh for graduating from CWRU with a BS in Physics, and staying in the lab as a research assistant, May 2020

• Katie for graduating from CWRU with a MS in Medical Physiology and remaining in the lab as a Research Assistant, May 2020

Papers Published

• "Lost in translation: Interpreting cardiac muscle mechanics data in clinical practice." is published in the Archives of Biochemistry and Biophysics, December 2019

• "The HCM-causing Y235S cMyBPC mutation accelerates contractile function by altering C1 domain structure" is published in Biochimica et Biophusica Acta (BBA) - Molecular Basis of Disease 

Grants Awarded

• NIH, R01 HL153236, 04/01/2021 – 03/31/2025

Welcome

• Katie Dominic, Masters Student Researcher, Department of Physiology and Biophysics, Case Western Reserve University, 2019 – 2021.

Papers Published

• Impact of the myosin modulator Mavacamten on force generation and cross-bridge behavior in a murine model of hypercontractility. Journal of the American Heart Association. 2018

• Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy. International Journal of Cardiology. 2018

• Dose-dependent effects of the myosin activator omecamtiv mecarbil on cross-bridge behavior and force generation in failing human myocardium. Circulation - Heart Failure, 2017, 

• Cardiac myosin binding protein C Ser302 phosphorylation regulates cardiac β-adrenergic reserve. Science – Advances. 2017.

• Sarcomeric protein modification during adrenergic stress enhances cardiac output and cross-bridge kinetics. Journal of Applied Physiology. 2017

• Modulation of length-dependent cross-bridge kinetics by cMyBPC phosphorylation. Frontiers in Physiology. 2016

• The contribution of myosin binding protein-C and troponin I phosphorylation to the β-adrenergic acceleration of left ventricular contraction and relaxation. Journal of Physiology. 2016

• Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C. Journal of Molecular and Cellular Cardiology 2015

•  Length-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation. Frontiers in Physiology. 2014,

•  Cardiac myosin binding protein C: a novel sarcomeric target for gene therapy. Pflugers Archives – European Journal of Physiology 2014

• The contribution of cMyBP-C Ser282 phosphorylation to the rate of force generation and in vivo cardiac contractility. Journal of Physiology. 2014

Grants Awarded

• NIH, S10 OD021635-01, 02/01/2016 – 01/31/2017

• NIH, R01 HL114770, 02/01/2013 – 01/31/2018, NCE until 01/31/2019

• AHA, 09SDG2050195, 07/01//2009 – 06/30/2013

Thesis Defence

• Kenneth Gresham (BSTP), CWRU SOM, Department of Physiology and Biophysics, 2016.

Welcome

• Joshua Holmes, Undergraduate Researcher, Department of Physics, Case Western Reserve University, 2017 – 2021.

• Chang-Yoon Doh, Undergraduate Researcher, Department of Biochemistry, Case Western Reserve University, 2016 – 2020. Currently: M4 – Case Western Reserve University.

• Jiayang Li, MSTP Student, 2014 – 2019. Currently: Resident, Vanderbilt University.

• Ranganath Mamidi, Postdoctoral Researcher, 2013 – 2021.

• Kenneth Gresham, PhD Student, Department of Physiology and Biophysics, 2013 – 2016. Currently: Postdoctoral Fellow – Temple University, Philadelphia.