"cMyBP-C in Hypertrophic Cardiomyopathy: Gene Therapy and Small-Molecule Innovations" is published in Frontiers Cardiovascular Medicine, February 2025
"Comparative mechanistic analysis of danicamtiv and omecamtiv mecarbil's in vivo cardiac effects" is published in the Journal of General Physiology, June 2025
Biological basis of cardiac thick filament regulation: NIH R01HL181868
Molecular Basis for cMyBP-C HCM variants: NIH 1R01HL175803-01A1
Patrick: Cleveland Kidney, Urology, and Hematology Training Award U2CDK129440, and TL1DK132770 06/01/2-25 - 06-01-2027
Katie for Best Presentation at this year's MSTP Retreat, July 2025.
Welcome Natalie Pachter, Postdoctoral Fellow. 2025-Present
Welcome Maria Iannucci, Research Assistant III/Lab Manager . 2025-Present
"Mechanism-based sarcomere manipulation to treat diastolic dysfunction in HFpEF" is published in Frontiers in Physiology, December 2024
“Differential effects of myosin activators on myocardial contractile function in non-failing and failing human hearts” is published in the American Journal of Physiology, October 2024
"Bringing into focus the central domains C3-C6 of myosin binding protein C" is published in Frontiers Physiology, February 2024
Josh: AHA Pre-Doctoral Fellowship 01/01/2025 – 12/31/2026
Yanqui: Clinical and Translational Science Collaborative grant, November 2024
Case-Coulter Translational Research Partnership: 10/1/2024-9/30/2025
Case Western Reserve University Council to Advance Human Health (CAHH): 10/01/2024-09-30/2025
Biological Basis of Genetic cMyBP-C Cardiomyopathies: NIH, R01 HL173989, 08/01/2024 – 06/30/2028
Computer modeling of myosin binding protein C and its effects on cardiac contraction, NIH 2RO1 HL146676, 04/01/2024-03/31/2028
Katie: AHA Pre-Doctoral Fellowship 01/01/2024 – 12/31/2025
Katie for passing her qualifying exam to advance to PhD candidacy, November 2024
Patrick for presenting at the Recknagel Symposium and earning this year's student academic achievement award. October 2024
Yoon for graduating from CWRU with an MD, and moving to Oregon Health and Science University to begin residency in Internal Medicine, May 2024
Josh for presenting a poster at the Myofilament Meeting in Madison, WI, May 2024
Welcome Michael Murphy, Research Associate, 2024-2025
Welcome Yanqui Shen. Research Associate, 2024-Present
Welcome Tharika, Undergraduate Researcher, 2024-Present
Welcome Patrick Wood, PhD Student, College of Wooster, 2024-Present
"Effect of the Novel Myotrope Danicamtiv on Cross-Bridge Behavior in Human Myocardium" is published in the Journal of the American Heart Association, October 2023
"Torsional and strain dysfunction precede overt heart failure in a mouse model of dilated cardiomyopathy pathogenesis" is published in the American Journal of Physiology-Heart and Circulatory Physiology, August 2023
"Basic science methods for the characterization of variants of uncertain significance in hypertrophic cardiomyopathy" is published in Frontiers Cardiovascular Medicine, July 2023
"The contribution of N-terminal truncated cMyBPC to in vivo cardiac function" is published in the Journal of General Physiology, April 2023
Lexi is awarded the Institutional Network Award for Promoting Kidney, Urologic, & Hematologic Research Training, 06/01/2023 – 05/31/2025
Roger is awarded the AHA Research Supplement to Promote Diversity in Science, 04/01/2023 - 03/31/2025
Josh for passing his qualifying exam to advance to PhD candidacy, November 2023
Katie for entering the PhD phase of the Medical Scientist Training Program, May 2023
Katie for giving an oral platform presentation at the Biophysical Society Meeting in San Diego, CA, February 2024
Welcome Alexandra Schmidt, Postdoctoral Fellow from the University of Pittsburgh
"Molecular characterization of linker and loop-mediated structural modulation and hinge motion in the C4-C5 domains of cMyBPC " is published in the Journal of Structural Biology, June 2022
"Identification of Phosphorylation and Other Post-Translational Modifications in the Central C4C5 Domains of Murine Cardiac Myosin Binding Protein C" is published
in the ACS Omega, April 2022
American Heart Association, 2022TPA961478, 07/01/2022 – 06/30/2025
Josh and Katie for presenting posters at the Myofilament Meeting in Madison, WI, May 2022
Welcome Rogelio Gonzalez Gonzalez, Postdoctoral Fellow from the Universidad a Autonoma de San Luis Potosi, Mexico 2022-Present
Welcome Joo-Hee Choi, Postdoctoral Researcher from Jeonbuk National University, South Korea, 2022-2024
Welcome Mandeep Singh, Research Associate, 2022-Present
"cMyBPC phosphorylation modulates the effect of omecamtiv mecarbil on myocardial force generation " is published in the Journal of General Physiology, March 2021
NIH, R01 HL153236, 04/01/2021 – 03/31/2025
StrideBio Inc., 11/01/2021 – 12/31/2022
Katie for entering medical school at CWRU, July 2021
John graduates from CWRU with an MD, and moves to Vanderbilt to enter the Physician Scientist Training Program for Internal Medicine residency, postdoctoral research fellowship, and clinical cardiology fellowship.
Michael Majcher, Postdoctoral Researcher, Department of Engineering, McMaster University, Hamilton, CA, 2021 – 2022.
"AAV9 gene transfer of cMyBPC N-terminal domains ameliorates cardiomyopathy in cMyBPC-deficient mice" is published in the Journal of Clinical Investigation – Insight, August 2020
"Prof. Cristobal dos Remedios and the Sydney Heart Bank: enabling translatable heart failure research" is published in Biophysical Reviews, June 2020
"Strategies for targeting the sarcomere; avenues for novel drug discovery" is published in Expert Opinion On Drug Discovery, April 2020
NIH, R01 HL146676, 04/1/2019 – 03/31/2023, NCE 03/31/2024
Yoon for entering medical school at CWRU, July 2020
Josh for graduating from CWRU with a BS in Physics, and staying in the lab as a research assistant, May 2020
Katie for graduating from CWRU with a MS in Medical Physiology and remaining in the lab as a Research Assistant, May 2020
"Lost in translation: Interpreting cardiac muscle mechanics data in clinical practice." is published in the Archives of Biochemistry and Biophysics, December 2019
"The HCM-causing Y235S cMyBPC mutation accelerates contractile function by altering C1 domain structure" is published in Biochimica et Biophusica Acta (BBA) - Molecular Basis of Disease
NIH, R01 HL153236, 04/01/2021 – 03/31/2025
Katie Dominic, Masters Student Researcher, Department of Physiology and Biophysics, Case Western Reserve University, 2019 – 2021.
Impact of the myosin modulator Mavacamten on force generation and cross-bridge behavior in a murine model of hypercontractility. Journal of the American Heart Association. 2018
Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy. International Journal of Cardiology. 2018
Dose-dependent effects of the myosin activator omecamtiv mecarbil on cross-bridge behavior and force generation in failing human myocardium. Circulation - Heart Failure, 2017,
Cardiac myosin binding protein C Ser302 phosphorylation regulates cardiac β-adrenergic reserve. Science – Advances. 2017.
Sarcomeric protein modification during adrenergic stress enhances cardiac output and cross-bridge kinetics. Journal of Applied Physiology. 2017
Modulation of length-dependent cross-bridge kinetics by cMyBPC phosphorylation. Frontiers in Physiology. 2016
The contribution of myosin binding protein-C and troponin I phosphorylation to the β-adrenergic acceleration of left ventricular contraction and relaxation. Journal of Physiology. 2016
Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C. Journal of Molecular and Cellular Cardiology 2015
Length-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation. Frontiers in Physiology. 2014,
Cardiac myosin binding protein C: a novel sarcomeric target for gene therapy. Pflugers Archives – European Journal of Physiology 2014
The contribution of cMyBP-C Ser282 phosphorylation to the rate of force generation and in vivo cardiac contractility. Journal of Physiology. 2014
NIH, S10 OD021635-01, 02/01/2016 – 01/31/2017
NIH, R01 HL114770, 02/01/2013 – 01/31/2018, NCE until 01/31/2019
AHA, 09SDG2050195, 07/01//2009 – 06/30/2013
Kenneth Gresham (BSTP), CWRU SOM, Department of Physiology and Biophysics, 2016.
Joshua Holmes, Undergraduate Researcher, Department of Physics, Case Western Reserve University, 2017 – 2021.
Chang-Yoon Doh, Undergraduate Researcher, Department of Biochemistry, Case Western Reserve University, 2016 – 2020. Currently: M4 – Case Western Reserve University.
Jiayang Li, MSTP Student, 2014 – 2019. Currently: Resident, Vanderbilt University.
Ranganath Mamidi, Postdoctoral Researcher, 2013 – 2021.
Kenneth Gresham, PhD Student, Department of Physiology and Biophysics, 2013 – 2016. Currently: Postdoctoral Fellow – Temple University, Philadelphia.