About Our Group
About Our Group
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The Nerve Block Factory lab is part of MetroHealth Medical Center's and the Case Western Reserve University's Departments of Physical Medicine and Rehabilitation and Biomedical Engineering. Our research focuses on the mechanisms and applications of electrical nerve block, both Kilohertz Frequency Alternating Current (KHFAC) nerve block and Direct Current (DC) nerve block.
The Nerve Block Factory lab is part of MetroHealth Medical Center's and the Case Western Reserve University's Departments of Physical Medicine and Rehabilitation and Biomedical Engineering. Our research focuses on the mechanisms and applications of electrical nerve block, both Kilohertz Frequency Alternating Current (KHFAC) nerve block and Direct Current (DC) nerve block.
(From Left) Kevin Kilgore, Niloy Bhadra, and Tina Vrabec perform bench testing to study electrochemistry, device building, and mechanical challenges. Photo from Cleveland FES Center
Featured Publications
Featured Publications
Bhadra, N., & Kilgore, K. L. (2004). Direct current electrical conduction block of peripheral nerve. IEEE Trans Neural Syst Rehabil Eng, 12(3), 313-324. doi:10.1109/TNSRE.2004.834205
Kilgore, K. L., & Bhadra, N. (2004). Nerve conduction block utilising high-frequency alternating current. Med Biol Eng Comput, 42(3), 394-406. doi:10.1007/BF02344716
Vrabec, T. L., Wainright, J. S., Bhadra, N., Shaw, L., Kilgore, K. L., & Bhadra, N. (2019). A carbon slurry separated interface nerve electrode for electrical block of nerve conduction. In Ieee Transactions on Neural Systems and Rehabilitation Engineering (Vol. 27, pp. 836-845): IEEE.
Bhadra, N., & Vrabec, T. (2015). Electrodes for electrical conduction block of the peripheral nerve. In S. Bhunia, S. Majerus, & M. Sawan (Eds.), Implantable Biomedical Microsystems (pp. 215-229): William Andrew.
Eggers, T. E., Green, D. B., Vrabec, T. L., Kilgore, K. L., & Bhadra, N. (2021). Electrical block of peripheral nerves. In Handbook of Neuroengineering (pp. 1-34): Springer.
Green, D. B., Kilgore, J. A., Bender, S. A., Daniels, R. J., Gunzler, D. D., Vrabec, T. L., & Bhadra, N. (2022). Effects of waveform shape and electrode material on KiloHertz frequency alternating current block of mammalian peripheral nerve. Bioelectron Med, 8(1), 11. doi:10.1186/s42234-022-00093-z
Thomas Eggers, D. G., Tina Vrabec, Kevin Kilgore, Niloy Bhadra. (2019). Chapter for Neuroengineering Handbook. In (Vol. 10, pp. 211-215).
Recent Publications
Recent Publications
Bender, S., Green, D., Hadaya, J., Haridas, S., Chan, C., Challita, R., . . . Vrabec, T. (2025). Closed-loop electrical block of vagus nerve scales from rodent to porcine cardiac models. J Neural Eng, 22(3). doi:10.1088/1741-2552/add8be
Bender, S. A., Green, D. B., Kilgore, K. L., Bhadra, N., Ardell, J. L., & Vrabec, T. L. (2024). Closed-Loop Multimodal Neuromodulation of Vagus Nerve for Control of Heart Rate. Proc Am Control Conf, 2024, 4536-4541. doi:10.23919/acc60939.2024.10644421
Green, D. B., Bender, S. A., Acker Iii, G. M. V., Hill, H. E., Kilgore, K. L., Bhadra, N., & Vrabec, T. L. (2025). Temporal properties of transcutaneous direct current motor conduction block. J Neural Eng, 22(1). doi:10.1088/1741-2552/adb07b
Vrabec, T., Bender, S., Chan, S. A., Cha, S., Haridas, S., Hanna, P., . . . Ardell, J. L. (2024). Bioelectronic block of stellate ganglia mitigates pacing-induced heterogeneous release of catecholamine and neuropeptide Y in the infarcted pig heart. J Physiol, n/a(n/a). doi:10.1113/JP286924
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