Case Studies

Genomics

Co-evolutional folding of nascent peptide chain during ribosomal translation (tested with Dunbrack http://dunbrack.fccc.edu)
Secondary structure & properties of RNAs - RNA transcript, miRNA precursor, matured mRNA & special classes of non-coding RNAs - tRNA, precursor RNA, small length RNAs (e.g. siRNA, sgRNA etc.).
Prediction of Translational delay across several mutations across 40 genes across 4 species
Modeling alternative splicing of introns leading to derivation of different protein products out of the same gene along with prediction of exon – intron boundary
Effect of SNP on both coding and non-coding region of DNA
Prediction of on-target and off-target binding of sgRNA on the target gene for CRISPR/Cas9

Model to study impact of Mutations on a Protein (derived of evolution of protein from primary residue to tertiary)
Model for protein – protein interaction to predict protein ‘hotspots’ defined as the residues which impede the protein interaction on mutation (In silico alanine mutagenesis for hotspot prediction methodology for Monoclonal Antibodies)
The effect of mutation on PD-L1 for its binding towards two MAbs (KN035 and Atezolizumab)
Binding Affinity of Insulin and other known Insulin Analogues with Insulin Receptor and IGF Receptor

Report abuse