Welcome to The Savita Devi Lab

A central focus of our lab is to understand the modulation of inflammasome activation at homeostasis and in various inflammatory diseases. Inflammation is a vital physiological process that contributes to the maintenance of homeostasis. Moreover, inflammation is also a central biological response to infection, cancer, and tissue damage. While it serves as a protective mechanism, the goal of acute inflammation is to get rid of the insult which cause them. But the purpose of the chronic inflammation is to adapt to the situation or the insults and that’s happens at the cost of the normal physiological function even it is not associated with tissue damage. Chronic or dysregulated inflammation contributes to the pathogenesis of a wide range of diseases, including autoimmune disorders, metabolic syndromes, neurodegenerative diseases, and malignancies.

Modern chronic diseases, such as metabolic disease, neurodegenerative disease, cancers all are inflammatory in the sense that they have inflammation component in it, however, inflammation in general is not causing it but it assists in perpetuating the disease state. And this aspect of inflammation that how it promotes chronic diseases or maintains the progression of these diseases is poorly understood.

A key part of this process involves structures in our cells called inflammasomes, which act like alarms that trigger inflammation when something goes wrong. The inflammasome, a multiprotein complex involved in the activation of inflammatory responses, plays a critical role in the regulation of cytokine production and cell death. Our research looks at: How these inflammasomes are turned on and off, and what might cause them to malfunction. How normal inflammation deviates to cause pathological state.

" The Savita Devi Lab utilizes the leading-edge Immunological, molecular, cellular and in-vivo approaches to decipher the novel immune regulatory mechanisms to advance the understanding of human immunity and identifying the novel targets for developing future therapies"

• Our research is focused on to better understand the complex regulatory mechanisms that maintain homeostasis and a well-balanced inflammatory response in humans. Specifically, we are interested to decipher role of inflammasome in modulating acute and chronic inflammation.

•    The design of novel modulators that can be targeted for improved treatment strategies to ultimately benefit patients.

•   We are expected to have a major impact and advance the field of human immunology.