Collaborate

All genetic screens require not only good perturbations, but also good models and good assays. CRISPR is great, but it isn't magic fairy dust: if the model is irrelevant or the assay is noisy, the screen will be uninformative.

Thus, in addition to research and development, a main focus of our group is to collaborate both within and outside Broad on gene function discovery projects. A major strength of the Platform model is that, with each new screen we do, we accumulate institutional knowledge that better informs the design, execution, and analysis of all subsequent projects. In other words, we've seen a lot of the ways that a screen can fail, and can help avoid those pitfalls going forward. 

As with all Platforms at the Broad, we work on a cost-recovery model, meaning the collaborating lab provides funding for reagents, time, and equipment. We frequently assist collaborators with grant proposals.

If you'd like to learn more, please check out this overview.