The dramatic impact of the PER-DBT interaction on circadian timekeeping and temperature compensation. Petersen, N.E., Sullivan, C., Ludewig, H., Kern, D., Rosbash, M. bioRxiv, 2025. doi: https://doi.org/10.1101/2025.02.01.636007
Chronic mitochondrial fragmentation elicits a neuroprotective Warburg effect. Richhariya, S., Shin, D., Schlichting, M., Rosbash, M. bioRxiv. 2024. doi: https://doi.org/10.1101/2024.08.30.610549 Submitted for publication.
Transcriptomic DN3 clock neuron subtypes regulate Drosophila sleep. Ma, D., Le, J.Q., Dai, X., Diaz, M.M., Abruzzi, K.C., Rosbash, M. Sci Adv. 2024. In the press.
Four SpsP neurons are an integrating sleep regulation hub in Drosophila. Dai, X., Le, J.Q., Ma, D., Rosbash, M. Sci Adv. 2024 Nov 22;10(47):eads0652 doi: 10.1126/sciadv.ads0652. PMID: 39576867
A Genome-Wide Analysis Indicates that Yeast Pre-mRNA Splicing Is Predominantly Posttranscriptional. Tardiff, D.F., Lacadie, S.A., Rosbash, M. Mol Cell. 2024. Aug 7:S1097-2765(24)00629-4 doi: 10.1016/j.molcel.2024.07.031. PMID: 39116873
Light and dopamine impact two circadian neurons to promote morning wakefulness. Le, J.Q., Ma, D., Dai, X., Rosbash, M. Curr Biol. 2024 Sep 9;34(17):3941-3954.e4. doi: 10.1016/j.cub.2024.07.056. PMID: 39142287
timeless non-coding DNA contains cell-type preferential enhancers important for proper Drosophila circadian regulation. Ma, D., Ojha, P., Yu, A.D., Arajuo, M.S., Luo, W., Keefer, E., Diaz, M.M., Wu, M., Joiner, W.J., Abruzzi, K.C., Rosbash, M. Proc Natl Acad Sci U S A. 2024 PMID: 38568969
BuTT-Seq: a new method for facile profiling of transcription. Yu, A.D. & Rosbash, M. Genes Dev. 2023 May 1;37(9-10):432-448. PMID: 37164645
Widespread post-transcriptional regulation of co-transmission. Chen, N., Zhang, Y., Rivera-Rodriguez, E.J., Yu, A.D., Hobin, M., Rosbash, M., Griffith, L.C. Sci Adv. 2023 Jun 2;9(22): PMID: 37267358
Comparison of TRIBE and STAMP for identifying targets of RNA binding proteins in human and Drosophila cells. Abruzzi, K.C., Ratner, C., Rosbash, M. RNA. 2023 May 11;rna.079608.123. doi: 10.1261/rna.079608.123. PMID: 37169395
Dissecting cell-specific functions of circadian genes using modified cell-specific CRISPR approaches. Richhariya, S., Shin, D., Le, J.Q., Rosbash, M. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2303779120. doi: 10.1073/pnas.2303779120. PMID: 37428902
Neural connectivity molecules best identify the heterogeneous clock and dopaminergic cell types in the Drosophila adult brain. Ma, D., Herndon, N., Le, J.Q., Abruzzi, K.C., Zinn, K., Rosbash, M. Sci Adv. 2023 Feb 22;9(8):eade8500. doi: 10.1126/sciadv.ade8500. PMID: 36812309
Dopamine and GPCR-mediated modulation of DN1 clock neurons gates the circadian timing of sleep. Schlichting, M., Richhariya, S., Herndon, N., Ma, D., Xin, J., Lenh, W., Abruzzi, K., Rosbash, M. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2206066119. doi: 10.1073/pnas.2206066119. PMID: 35969763
Recurrent circadian circuitry regulates central brain activity to maintain sleep. Sun, L., Jiang, R.H., Ye, W.J., Rosbash, M., Guo, F. Neuron. 2022 May 2;S0896-6273(22)00349-X. doi: 10.1016/j.neuron.2022.04.010. PMID: 35525241
Transposable element landscapes in aging Drosophila. Yang, N, Srivastav S.P., Rahman, R., Ma, Q., Dayama, G., Li, S., Chinen, M., Lei, E.P., Rosbash, M., Lau, N.C. PLoS Genet. 2022 Mar 3;18(3):e1010024. doi: 10.1371/journal.pgen.1010024. PMID: 35239675
Targeted RNA editing: novel tools to study post-transcriptional regulation. Xu, W., Biswas, J., Singer, R.H., Rosbash, M. Mol Cell. 2022 Jan 20;82(2):389-403. doi: 10.1016/j.molcel.2021.10.010. PMID: 34739873
Protocol for using TRIBE to study RNA-protein interactions and nuclear organization in mammalian cells. Biswas, J., Rosbash, M., Singer, R.H., Rahman, R. STAR Protoc. 2021 Jun 30;2(3):100634. doi: 10.1016/j.xpro.2021.100634. PMID: 34258595
Loop-Mediated Isothermal Amplification Detection of SARS-CoV-2 and Myriad Other Applications. Moore, K.J.M.…. Rosbash, M. et al. J Biomol Tech. 2021 Sep;32(3):228-275. doi: 10.7171/jbt.21-3203-017. PMID: 35136384
Development of a saliva-optimized RT-LAMP assay for SARS-CoV-2. Yu, A.D., Galatsis, K., Zheng, J., Le, J.Q., Ma, D., Perlman, S., Rosbash, M. J Biomol Tech. 2021 Sep;32(3):102-113. doi: 10.7171/jbt.21-3203-005. PMID: 35027868
Comment on “Circadian rhythms in the absence of the clock gene Bmal1.” Abruzzi K.C., Gobet C., Naef F., Rosbash M. Science. 2021 Apr 16;372(6539). eabf0922. doi: 10.1126/science.abf0922. PMID: 33859000
Circadian rhythms and the transcriptional feedback loop (Nobel Lecture). Rosbash, M. Angew Chem Int Ed Engl. 2021 Feb 26. doi: 10.1002/anie.202015199. PMID: 33634573
A transcriptomic taxonomy of Drosophila circadian neurons around the clock. Ma, D., Przybylski, D., Abruzzi, K.C., Schlichting, M., Li, Q., Long, X., Rosbash, M. Elife. 2021 Jan 13;10:e63056. doi: 10.7554/eLife.63056. PMID: 33438579
Internal state configures olfactory behavior and early sensory processing in Drosophila larvae. Vogt, K., Zimmerman, D.M., Schlichting, M., Hernandez-Nunez, L., Qin, S., Malacon, K., Rosbash, M., Pehlevan, C., Cardona, A., Samuel, A.D.T. Sci Adv. 2021 Jan 1;7(1):eabd6900. doi: 10.1126/sciadv.abd6900. PMID: 33523854
Phosphatase of regenerating liver-1 selectively times circadian behavior in darkness via function in PDF neurons and dephosphorylation of TIMELESS. Kula-Eversole, E., Lee, D.H., Samba, I., Yildirim, E., Levine, D.C., Hong, H.K., Lear, B.C., Bass, J., Rosbash, M., Allada, R. Curr Biol. 2021 Jan 11;31(1):138-149.e5. doi: 10.1016/j.cub.2020.10.013. PMID: 33157022
Rosbash M. Metformin treatment of the C9orf72 ALS/FTD mouse: Almost too good for words. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):19627-19628. doi: 10.1073/pnas.2012363117. Epub 2020 Jul 29. PMID: 32727895; PMCID: PMC7443920.
Jin H, Xu W, Rahman R, Na D, Fieldsend A, Song W, Liu S, Li C, Rosbash M. TRIBE editing reveals specific mRNA targets of eIF4E-BP in Drosophila and in mammals. Sci Adv. 2020 Aug 12;6(33):eabb8771. doi: 10.1126/sciadv.abb8771. PMID: 32851185; PMCID: PMC7423359.
MS2-TRIBE Evaluates Both Protein-RNA Interactions and Nuclear Organization of Transcription by RNA Editing. Biswas J, Rahman R, Gupta V, Rosbash M, Singer RH. iScience. 2020 Jun 28;23(7):101318. doi: 10.1016/j.isci.2020.101318. PMID: 32674054
TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression. Herzog JJ, Xu W, Deshpande M, Rahman R, Suib H, Rodal AA, Rosbash M, Paradis S. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11760-11769. doi: 10.1073/pnas.1917038117. Epub 2020 May 11. PMID: 32393629
Video Recording Can Conveniently Assay Mosquito Locomotor Activity. Araujo MDS, Guo F, Rosbash M. Sci Rep. 2020 Mar 19;10(1):4994. doi: 10.1038/s41598-020-61733-5. PMID: 32193470
A Serotonin-Modulated Circuit Controls Sleep Architecture to Regulate Cognitive Function Independent of Total Sleep in Drosophila. Liu C, Meng Z, Wiggin TD, Yu J, Reed ML, Guo F, Zhang Y, Rosbash M, Griffith LC. Curr Biol. 2019 Nov 4;29(21):3635-3646.e5. doi: 10.1016/j.cub.2019.08.079. Epub 2019 Oct 24. PMID: 31668619
Neuron-specific knockouts indicate the importance of network communication to Drosophila rhythmicity. Schlichting M, Díaz MM, Xin J, Rosbash M. Elife. 2019 Oct 15;8:e48301. doi: 0.7554/eLife.48301. PMID: 31613223
Light-Mediated Circuit Switching in the Drosophila Neuronal Clock Network. Schlichting M, Weidner P, Diaz M, Menegazzi P, Dalla Benetta E, Helfrich-Förster C, Rosbash M. Curr Biol. 2019 Oct 7;29(19):3266-3276.e3. doi: 10.1016/j.cub.2019.08.033. Epub 2019 Sep 26. PMID: 31564496
Medicine in the Fourth Dimension. Cederroth CR, Albrecht U, Bass J, Brown SA, Dyhrfjeld-Johnsen J, Gachon F, Green CB, Hastings MH, Helfrich-Förster C, Hogenesch JB, Lévi F, Loudon A, Lundkvist GB, Meijer JH, Rosbash M, Takahashi JS, Young M, Canlon B. Cell Metab. 2019 Aug 6;30(2):238-250. doi: 10.1016/j.cmet.2019.06.019. PMID: 31390550
A Distinct Visual Pathway Mediates High-Intensity Light Adaptation of the Circadian Clock in Drosophila. Schlichting M, Menegazzi P, Rosbash M, Helfrich-Förster C. J Neurosci. 2019 Feb 27;39(9):1621-1630.
Allatostatin-C/AstC-R2 Is a Novel Pathway to Modulate the Circadian Activity Pattern in Drosophila. Díaz MM, Schlichting M, Abruzzi KC, Long X, Rosbash M. Curr Biol. 2019 Jan 7;29(1):13-22.e3. doi: 10.1016/j.cub.2018.11.005.
NonA and CPX Link the Circadian Clockwork to Locomotor Activity in Drosophila. Luo W, Guo F, McMahon A, Couvertier S, Jin H, Diaz M, Fieldsend A, Weerapana E, Rosbash M. Neuron. 2018 Jul 24. pii: S0896-6273(18)30541-5. doi: 10.1016/j.neuron.2018.07.001.
Identification of RNA-binding protein targets with HyperTRIBE. Rahman R, Xu W, Jin H, Rosbash M. Nat Protoc. 2018 Aug;13(8):1829-1849. doi: 10.1038/s41596-018-0020-y.
Striking circadian neuron diversity and cycling of Drosophila alternative splicing. Wang Q, Abruzzi KC, Rosbash M, Rio DC. Elife. 2018 Jun 4;7. pii: e35618. doi: 10.7554/eLife.35618.
Mechanistic implications of enhanced editing by a HyperTRIBE RNA-binding protein. Xu W, Rahman R, Rosbash M. RNA. 2018 Feb;24(2):173-182. doi: 10.1261/rna.064691.117.
A Circadian Output Circuit Controls Sleep-Wake Arousal in Drosophila. Guo F, Holla M, Díaz MM, Rosbash M. Neuron. 2018 Nov 7;100(3):624-635.e4. doi: 10.1016/j.neuron.2018.09.002.
Life Is an N of 1. Rosbash M. Cell. 2017 Nov 30;171(6):1241-1245.
Guidelines for Genome-Scale Analysis of Biological Rhythms. Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptáček LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB. J Biol Rhythms. 2017 Oct;32(5):380-393.
Temporal calcium profiling of specific circadian neurons in freely moving flies. Guo F, Chen X, Rosbash M. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8780-E8787.
A 50-Year Personal Journey: Location, Gene Expression, and Circadian Rhythms. Rosbash M. Cold Spring Harb Perspect Biol. 2017 Jun 9. pii: a032516. doi: 10.1101/cshperspect.a032516.
Nonreciprocal homeostatic compensation in Drosophila potassium channel mutants. Kim EZ, Vienne J, Rosbash M, Griffith LC. J Neurophysiol. 2017 Jun 1;117(6):2125-2136.
MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila. Chen X, Rosbash M. Nature Communications 2017 Mar 9;8:14707.
A pupal transcriptomic screen identifies Ral as a target of store-operated calcium entry in Drosophila neurons. Richhariya S, Jayakumar S, Abruzzi K, Rosbash M, Hasan G. Scientific Reports 2017 Feb 14;7:42586.
RNA-seq analysis of Drosophila clock and non-clock neurons reveals neuron-specific cycling and novel candidate neuropeptides. Abruzzi KC, Zadina A, Luo W, Wiyanto E, Rahman R, Guo F, Shafer O, Rosbash M. PLoS Genetics 2017 Feb 9;13(2):e1006613.
Fluorescence circadian imaging reveals a PDF-dependent transcriptional regulation of the Drosophila molecular clock. Sabado V, Vienne L, Nunes JM, Rosbash M, Nagoshi E. Scientific Reports 2017 Jan 30;7:41560.
Five suggestions for substantial NIH reforms. Rosbash M. Elife. 2016 Dec 14;5.
Genome-wide identification of neuronal activity-regulated genes in Drosophila. Chen X, Rahman R, Guo F, Rosbash M. Elife. 2016 Dec 9;5.
Circadian neuron feedback controls the Drosophila sleep-activity profile. Guo, F, Yu, J, Jung, HJ, Abruzzi, KC, Luo, W, Griffith, L, and Rosbash, M. Nature. 2016, 536:292-297.
Age-Related Reduction of Recovery Sleep and Arousal Threshold in Drosophila. Vienne, J, Spann, R, Guo, F, and Rosbash, M. Sleep.2016, 39(8):1613-1624.
Promiscuous or discriminating: Has the favored mRNA target of Fragile X Mental Retardation Protein been overlooked?. McMahon, AC, and Rosbash, M. Proc.Natl.Acad.Sci.U.S.A. 2016, 113(26):7009-7011.
mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression. Chen X, and Rosbash, M. Proc. Natl. Acad. Sci. U.S.A. 2016, 113(21):E2965-72.
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins. McMahon, A, Rahman, R, Jin, H, Shen, JL, Fieldsend, A, Luo, W, and Rosbash, M. Cell. 2016 165, 742-753.
Clk post-transcriptional control denoises circadian transcription both temporally and spatially. Lerner I, Bartok O, Wolfson V, Menet JS, Weissbein U, Afik S, Haimovich D, Gafni C, Friedman N, Rosbash M, Kadener S. Nat Commun. 2015 May 8;6:7056.
We’ll always have RNA. Rosbash M. RNA. 2015 Apr;21(4):546-7.
RNA-seq profiling of small numbers of Drosophila neurons. Abruzzi K, Chen X, Nagoshi E, Zadina A, Rosbash M. Methods Enzymol. 2015;551:369-86.
Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED. Hadzic T, Park D, Abruzzi KC, Yang L, Trigg JS, Rohs R, Rosbash M, Taghert PH. Nucleic Acids Res. 2015 Feb 27;43(4):2199-215.
PDF neuron firing phase-shifts key circadian activity neurons in Drosophila. Guo F, Cerullo I, Chen X, Rosbash M. Elife. June 17:e02780.
PDF and cAMP enhance PER stability in Drosophila clock neurons. Li, Y., Guo, F., Shen, J., Rosbash, M. Proc.Natl.Acad.Sci.U.S.A. 111:E1284-90.
CLOCK:BMAL1 is a pioneer-like transcription factor. Menet, J.S., Pescatore, S., Rosbash, M. Genes Dev. 28:8-13.
CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila. Luo, W., Tang, C.H., Abruzzi, K.C., Rodriguez, J., Pescatore, S., Rosbash, M. Genes Dev. 26:2536-2549.
Nascent-Seq reveals novel features of mouse circadian transcriptional regulation. Menet, J.S., Rodriguez, J., Abruzzi, K.C., Rosbash, M. eLife. 1:e00011.
The Oscillating miRNA 959-964 Cluster Impacts Drosophila Feeding Time and Other Circadian Outputs. Vodala, S., Pescatore, S., Rodriguez, J., Buescher, M., Chen, Y.W., Weng, R., Cohen, S.M., Rosbash, M. Cell Metab. 16:601-612.
Cotranscriptional splicing efficiency differs dramatically between Drosophila and mouse. Khodor, Y.L., Menet, J.S., Tolan, M., Rosbash, M. RNA. 18:2174-2186.
NAT1/DAP5/p97 and Atypical Translational Control in the Drosophila Circadian Oscillator. Bradley, S., Narayanan, S., Rosbash, M. Genetics. 192:943-957.
Autoreceptor Control of Peptide/Neurotransmitter Corelease from PDF Neurons Determines Allocation of Circadian Activity in Drosophila. Choi, C., Cao, G., Tanenhaus, A.K., McCarthy, E.V., Jung. M., Schleyer, W., Shang, Y., Rosbash, M., Yin, J.C., Nitabach, M. N. Cell Rep. 2:332-344 [pdf]
Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila. Rodriguez, J., Menet, J.S., Rosbash, M. Mol Cell. 47:27-37.
Nascent-seq indicates widespread cotranscriptional pre-mRNA splicing in Drosophila. Khodor, Y.L., Rodriguez, J., Abruzzi, K.C., Tang, C.H., Marr, M.T. II, Rosbash, M. Genes Dev. 25:2502-2512.
Drosophila CLOCK Target Gene Characterization: Implications for Circadian Tissue-Specific Gene Expression. Abruzzi, K.C., Rodriguez, J., Menet, J.S., Desrochers, J., Zadina, A., Luo, W., Tkachev, S., Rosbash, M. Genes Dev. 25:2374-2386.
When brain clocks lose track of time: cause or consequence of neuropsychiatric disorders. Menet, J.S., Rosbash M. Curr Opin Neurobiol. 2011 Dec;21(6):849-57.
Molecular Organization of Drosophila Neuroendocrine Cells by Dimmed. Park, D., Hadžic, T., Yin, P., Rusch, J., Abruzzi, K.C., Rosbash, M., Skeath, J.B., Panda, S., Sweedler, J.V., Taghert, P.H. Curr. Biol. 21:1515-1524. [pdf]
A new twist on clock protein phosphorylation: A conformational change leads to protein degradation. Menet, J.S., Rosbash, M. Mol Cell. 43:695-697.
A threat to medical innovation. Rosbash, M. Science. 333:136.
Imaging analysis of clock neurons: light buffers the wake-promoting effect of dopamine. Shang, Y., Haynes, P., Pírez, N., Harrington, K., Guo, F., Pollack, J., Hong, P., Griffith, L.C., Rosbash, M. Nat. Neurosci. 14:889-895.
Genome-wide analysis of light and temperature-entrained circadian transcripts in C. elegans. van der Linden A.M., Beverly, M., Kadener, S., Rodriguez, J., Wasserman, S., Rosbash, M., Sengupta, P. PLoS Biology. 8:e1000503.
Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. Kula-Eversole, E., Nagoshi, E., Shang, Y., Rodriguez, J., Allada, R., Rosbash, M. PNAS. Jul 12.
Light-mediated TIM degradation within Drosophila pacemaker neurons (s-LNvs) is neither necessary nor sufficient for delay zone phase shifts. Tang, C.H., Hinteregger, E., Shang, Y., Rosbash, M. Neuron. 66:378-385.
Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA. Menet, J.S., Abruzz,i K.C., Desrochers, J., Rodriguez, J., Rosbash, M. Genes Dev. 24:358-367.
Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. Nagoshi, E., Sugino, K., Kula, E., Okazaki, E., Tachibana, T., Nelson, S., Rosbash, M. Nat Neurosci.13:60-68.
A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses. Dubruille, R., Murad, A., Rosbash, M., Emery, P. PLoS Genet. 5(12).
A role for microRNAs in the Drosophila circadian clock. Kadener, S., Menet, J.S., Sugino, K., Horwich, M.D., Weissbein, U., Nawathean, P., Vagin, V.V., Zamore, P.D., Nelson, S.B., Rosbash, M. Genes Dev. 23:2179-2191.
A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction. Hage, R., Tung, L., Du, H., Stands, L., Rosbash, M., Chang, T.H. MCB. 29:3941-3952.
Genome-wide identification of targets of the drosha-pasha/DGCR8 complex. Kadener, S., Rodriguez, J., Abruzzi, K.C., Khodor, Y.L., Sugino, K., Marr, M.T. II, Nelson, S., Rosbash, M. RNA. 15:537-545.
The implications of multiple circadian clock origins. Rosbash, M. PLoS Biol. 7:e62.
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain. Shang, Y., Griffith, L.C., Rosbash, M. PNAS. 105:19587-19594.
PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. Parisky, K.M., Agosto, J., Pulver, S.R., Shang, Y., Kuklin, E., Hodge, J.J., Kang, K., Liu, X., Garrity, P.A., Rosbash, M., Griffith, L.C. Neuron. 60:672-682.
The nuclear exosome and adenylation regulate posttranscriptional tethering of yeast GAL genes to the nuclear periphery. Vodala, S., Abruzzi, K.C., Rosbash, M. Mol Cell. 31:104-113.
Circadian transcription contributes to core period determination in Drosophila. Kadener, S., Menet, J.S., Schoer, R., Rosbash, M. PLoS Biology. 6:e119.
Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila. Agosto, J., Choi, J.C., Parisky, K.M., Stilwell, G., Rosbash, M., Griffith, L.C. Nat Neurosci. 11:354-9.
Sleep: hitting the reset button. Griffith, L.C., Rosbash, M. Nat Neurosci. 11:123-124.
Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. Chekanova, J.A., Abruzzi, K.C., Rosbash, M., Belostotsky, D.A. RNA. 14:66-77.
Transcriptional feedback and definition of the circadian pacemaker in Drosophila and animals. Rosbash, M., Bradley, S., Kadener, S., Li, Y., Luo, W., Menet, J.S., Nagoshi, E., Palm, K., Schoer, R., Shang, Y., Tang, C.H. Cold Spring Harb Symp Quant Biol.72:75-83.
Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking. Tardiff, D.F., Abruzzi, K.C., Rosbash, M. PNAS. 104:19948-19953.
Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Kadener, S., Stoleru, D., McDonald, M., Nawathean, P., Rosbash, M. Genes Dev. 21:1675-1686.
A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization and transcriptional repressor activity. Nawathean, P., Stoleru, D., Rosbash, M. MCB. 27:5002-5013.
PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila. Kaushik, R., Nawathean, P., Busza, A., Murad, A., Emery, P., Rosbash, M. PLoS Biology. 5:e146.
The Drosophila circadian neuronal network is a seasonal timer. Stoleru, D., Nawathean, P., de la Paz Fernandez, M., Menet, J.S., Fernanda Ceriani, M., Rosbash, M. Cell. 27:207-219.
A novel plasmid based microarray screen identifies suppressors of rrp6{delta} in Saccharomyces cerevisiae. Abruzzi, K., Denome, S., Olsen, J.R., Assenholt, J., Haaning, L.L., Jensen, T.H., Rosbash, M. MCB. 27:1044-1055.
A genome wide analysis indicates that yeast pre-mRNA splicing is predominantly post-transcriptional. Tardiff, D.F., Lacadie, S.A., Rosbash, M. Mol Cell. 24:917-929.
3′-end formation signals modulate the association of genes with the nuclear periphery as well as mRNP dot formation. Abruzzi, K.C., Belostotsky, D.A., Chekanova, J.A., Dower, K., Rosbash, M. EMBO. 25:4253-62.
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila. Kadener, S., Villella, A., Kula, E., Palm, K., Pyza, E., Botas, J., Hall, J.C., Rosbash, M. PNAS. 103:13537-13542.
In vivo commitment to yeast cotranscriptional splicing is sensitive to transcriptional elongation mutants. Lacadie, S.A., Tardiff, D.F., Kadener, S., Rosbash, M. Genes Dev. 20:2055-2066.
Arrested yeast splicing complexes indicate stepwise snRNP recruitment during in vivo spliceosome assembly. Tardiff, D.F., Rosbash, M. RNA 12:968-979.
PDF cycling in the dorsal protocerebrum of the Drosophila brain is not necessary for circadian clock function. Kula, E., Levitan, E.S., Pyza, E., Rosbash, M. J Biol Rhythms. 21:104-117.
A resetting signal between Drosophila pacemakers synchronizes morning and evening activity. Stoleru, D., Peng, Y., Nawathean, P., Rosbash, M. Nature 438:238-242.
Co-transcriptional spliceosome assembly dynamics and the role of U1 snRNA:5’ss base pairing in yeast. Lacadie, S.A. and Rosbash, M. Mol Cell 19:65-75.
PERIOD1-associated proteins modulate the negative limb of the mammalian circadian clock. Brown, S.A., Ripperger, J., Kadener, S., Fleury-Olela, F., Vilbois, F., Rosbash, M., Schibler, U. Science 308:693-6.
Assaying the Drosophila negative feedback loop with RNAi in S2 cells. Nawathean, P., Menet, J.S., Rosbash, M. Methods In Enzymology, 393:610-622.
A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript. Dower, K., Kupperwasser, N., Merrikh, H., Rosbash, M. RNA 10:1888-1899.
NMD does not occur within the yeast nucleus. Kuperwasser, N., Brogna, S., Dower, K., Rosbash, M. RNA 10: 1907-1915.
Coupled oscillators control morning and evening locomotor activity behavior of Drosophila. Stoleru, D., Peng, Y., Agosto, J., Rosbash, M. Nature 431:862-868.
Effects of the U1C L13 Mutation and Temperature Regulation of Yeast Commitment Complex Formation. Du, H., Tardiff, D.F., Moore, M.J., Rosbash, M. PNAS 101:14841-14846.
Biochemical analysis of TREX complex recruitment to intronless and intron-containing yeast genes. Abruzzi, K.C., Lacadie, S., Rosbash, M. EMBO J 23:2620–2631.
Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Busza, A., Emery-Le, M., Rosbash, M., Emery, P. Science 304:1503-1506.
The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. Nawathean, P. and Rosbash, M. Mol Cell 13:213-223.
The Co-evolution of Blue-Light Photoreception and Circadian Rhythms. Ghering, W.and Rosbash, M. J Mol Evol. 57:S286-S289.
Drosophila free-running rhythms require intercellular communication. Peng, Y., Stoleru, D., Levine, J.D., Hall, J.C., Rosbash, M. PLoS 1:32-40.
Localization of nuclear retained mRNAs in Saccharomyces cerevisiae. Thomsen, R., Libri, D., Boulay, J., Rosbash, M., Heick Jensen, T. RNA 9:1049-1057.
A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude. Allada, R., Kadener, S., Nandakumar, N., Rosbash, M. EMBO J 22:3367-3375.
Circadian rhythms in Drosophila. Rosbash, M., Allada, R., McDonald, M., Peng, Y., Zhao, J. Novartis Foundation Symposium 253: Molecular Clocks and Light Signalling (eds. Chadwick DJ, and Goode JA), 223-237. John Wiley & Sons Ltd., Chichester, UK.
Drosophila Clock can generate ectopic circadian clocks. Zhao, J., Kilman, V., Keegan, K., Peng, Y., Emery, P., Rosbash, M., Allada, R. Cell 113:755-766.
Early formation of mRNP: License for export or quality control. Heick Jensen, T., Dower, K., Libri, D., Rosbash, M. Cell 11:1129-1138.
A biological clock. Rosbash, M. Daedalus 132:27-36.
Co-transcriptional monitoring of mRNP formation. Heick Jensen, T. and Rosbash, M. Nature Structural Biology 10:10-12.
Circadian Rhythms: The cancer connnection. Rosbash, M. and Takakashi, J.S. Nature 420: 373-374.
A role for casein kinase 2a in the Drosophila circadian clock. Lin, J.M., Kilman, V.L., Keegan, K., Paddock, B., Emery-Le, M., Rosbash, M., Allada, R. Nature 420(6917):816-20.
Interactions between mRNA export commitment, 3′ -end quality control and nuclear degradation. Libri, D., Dower, K., Boulay, J., Thomsen, R., Rosbash, M., Jensen, T.H. MCB 22:8254-8266.
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing. Du, H. and Rosbash, M. Nature 149:86-92.
Ribosomes components are associated with sites of transcription. Brogna, S., Sato, T.A., Rosbash, M. Mol. Cell 10: 93-104.
Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster. Shafer, O.T., Allada, R., Rosbash, M., Truman, J.W. J Neurosci. 22: 5946-5954.
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation. Kadener, S., Fededa, J.P., Rosbash, M., Kornblihtt, A.R. PNAS 99:8185-8190.
T7 RNA polymerase-directed transcripts are processed in yeast and link 3′ end formation to mRNA nuclear export. Dower, K. and Rosbash, M. RNA 8:686-697.
Microarray analysis and organization of circadian gene expression in Drosophila. McDonald, M. and Rosbash, M. Cell 107:567-578.
Cell Biology: TAPping into mRNA Export. Moore, M.J. and Rosbash, M. Science 294:1841-1842.
The DECD-box putative ATPase Sub2p is an early mRNA export factor. Heick Jensen, T., Boulay, J., Rosbash, M., Libri, D. Current Biol. 11:1711-1715.
Quality control of mRNA 3′-end processing is linked to the nuclear exosome. Hilleren, P., McCarthy, T., Rosbash, M., Parker, R., Heick Jensen, T. Nature 413:538-542.
Stopping Time: The Genetics of Fly and Mouse Circadian Rhythms. Allada, R., Emery, P., Takahashi, J.S., Rosbash, M. Ann. Rev. Neurosci. 24:1091-1119.
Recognition of RNA branchpoint sequences by SF1/mBBP in a splicing factor complex. Peled-Zehavi, Z., Berglund, J.A., Rosbash, M., Frankel, A.D. MCB 21:5232-5241.
Crystal structure of a model branchpoint – U2 snRNA duplex containing bulged adenosines. Berglund, J.A., Rosbash, M., Schultz, S.C. RNA 7:682-691.
A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription. Heick Jensen, T., Patricio, K., McCarthy, T., Rosbash, M. Mol.Cell 7:887-898.
Fly Clocks: The Molecular Genetics of Circadian Rhythms. Allada, R. and Rosbash, M. Genetic Models in Cardiorespiratory Biology (eds. Haddad, G.G., and Tian, X.), pp.365-390. Marcel Dekker, Inc., New York, NY.
A Biochemical Function for the Sm Complex. Zhang, D., Abovich, N., Rosbash, M. Mol. Cell 7:319-329.
Yeast U1 snRNP-pre-mRNA complex formation without U1 snRNP-pre-mRNA base pairing. Du, H., and Rosbash, M. RNA 7:133-142.
Wild-type circadian rhythmicity is dependent on closely spaced E-boxes in the Drosophila timeless promoter. McDonald, M., Rosbash, M., Emery, P. MCB 21:1207-1217.
A common core RNP structure shared between the small nucleolar box C/D RNPs and the spliceosomal U4 snRNP. Watkins, N.J., Segauly, V., Charpentier, B., Nottrott, S., Fabrizio, P., Bachi, A., Wilm, M., Rosbash, M., Branlant, C., Luhrmann, R. Cell 103:457-466.
Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: Cell cycle-regulated transcription factor Ace2p shows cell cycle-independent nucleocytoplasmic shuttling. Heick Jensen, T,, Neville, M., Rain, J.C., McCarthy, T., Legrain, P., Rosbash, M. MCB 20:8047-8058.
Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila. Suri, V., Hall, J., Rosbash, M. J Neurosci. 20:7547-7555.
takeout, a novel Drosophila gene under circadian clock transcriptional regulation. So, W.V., Sarov-Blat, L., Kotarski, C.K., McDonald, M.J., Allada, R., Rosbash, M. MCB 20:6935-6944.
The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior. Sarov-Blat, L., So, W.V., Liu, L., Rosbash, M. Cell 101:647-656.
Drosophila CRY is a deep brain circadian photoreceptor. Emery, P., Stanewsky, R., Helfrich-Forster, C., Emery-Le, M., Hall, J.C., Rosbash, M. Neuron 26:493-504.
Nuclear export of heat shock and non-heat-shock mRNA occurs via similar pathways. Vainberg, I.E., Dower, K., Rosbash, M. MCB 20:3996-4005.
A unique circadian-rhythm photoreceptor. Emery, P., Stanewsky, R., Hall, J.C., Rosbash, M. Nature 404:456-457.
Splicing enhancement in the yeast rp51b intron. Libri, D., Lescure, A., Rosbash, M. RNA 6:352-368.
Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Park, J.H., Helfrich-Forster, C., Lee, G., Liu, L., Rosbash, M., Hall, J.C. PNAS 97:3608-3613.