The Brandeis University Mass Spectrometry Facility is equipped with three mass spectrometers: A Waters Micromass ZQ, Perkin Elmer Axion 2 TOF MS, and Bruker timsTOF Pro. The Waters instruments is available for open access operation after instruction by the facility director. All instruments are available for internal and external research collaborations. Please contact Dr. Schulte if you have any questions.
The Waters Micromass ZQ is a low-resolution single quad instrument that is operated in both ESI positive and negative modes and is a robust system for nominal mass determination of peptides or organic synthesis products that ionize by ESI. The instrument is coupled to an Acquity UHPLC that allows the collection of experimental data via flow injection analysis or chromatographic separation using reverse-phase columns.
The Axion 2 TOF MS is a time-of-flight instrument equipped with an ESI source that is utilized in positive and negative mode to measure organic synthesis products at high resolution and mass accuracy. The instrument is equipped with a Flexar UHPLC system that is both amenable for flow injection analysis and reverse-phase chromatography.
The Bruker timsTOF Pro is our boutique instrument and allows the analysis of a wide range of molecules in MS and MS/MS mode at high resolution via ESI in positive and negative mode. For the online separation of analyte ions in the gas phase, the system contains an IMS unit that allows the resolution of isobaric compounds. The system is equipped with an Elute UHPLC chromatograph for metabolomics and small molecules and a nanoElute nanoflow chromatograph for proteomics analyses.