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Research in the Microfluidics and Multiphase Flow Laboratory at the State University of New York at Binghamton is highly interdisciplinary; incorporating aspects of advanced manufacturing, multiphase flows, interfacial science, microfluidics, and biotechnology. We are using electrospray to deposit materials for microelectronics applications and to probe the physics of interfacial transport. We are building microfluidic instrumentation to produce highly-customizable asymmetric vesicles with controllable membrane composition, size, and luminal content. These synthetic vesicles support fundamental studies on bacterial biofilms and membrane biology. Finally, our team is part of a diverse group exploring the fluid mechanics of the brain.
Research in the Microfluidics and Multiphase Flow Laboratory at the State University of New York at Binghamton is highly interdisciplinary; incorporating aspects of advanced manufacturing, multiphase flows, interfacial science, microfluidics, and biotechnology. We are using electrospray to deposit materials for microelectronics applications and to probe the physics of interfacial transport. We are building microfluidic instrumentation to produce highly-customizable asymmetric vesicles with controllable membrane composition, size, and luminal content. These synthetic vesicles support fundamental studies on bacterial biofilms and membrane biology. Finally, our team is part of a diverse group exploring the fluid mechanics of the brain.
Advanced Manufacturing Using Electrospray Deposition
Advanced Manufacturing Using Electrospray Deposition
Electrospray deposition/printing is a powerful technique for creating highly conformal thin films of metals, semiconductors, and polymers. We are exploring the important role electric change plays in governing the physics of electrospray deposition, recently incorporating the use of artificial intelligence to enhance our understanding and control of this process. Our work on electrospray supports applications in microelectronics manufacturing and packaging.
Customized Synthetic Asymmetric Vesicles Built Using High-throughput Microfluidics
Customized Synthetic Asymmetric Vesicles Built Using High-throughput Microfluidics
Membrane vesicles are spherical structures comprised of a single lipid bilayer encircling an aqueous cavity, or lumen. In nature, these structures carry out many important functions in both eukaryotic and prokaryotic organisms. Membrane asymmetry, where the lipid composition in each leaflet of the bilayer is different, is an important (but difficult to obtain) feature as it is a characteristic of nearly all natural membranes. We have created a strategy to engineer synthetic asymmetric vesicles at high-throughput using a combination of novel microfluidic techniques. Using the precise flow control offered by microfluidic devices, we have built asymmetric vesicles with controlled membrane composition, size, and luminal content.Â
Interfacial Transport
Interfacial Transport
We are exploring the interfacial transport of evaporating sessile droplets with uniform and non-uniform curvature by delivering nano- and micro- scale particles to the droplet surface using electrospray. Along with capillary forces and the effect of Marangoni flow, the use of electrospray means that electric charge also plays an important role in governing the transport and ordering of the particles. Upon evaporation, the sessile droplet interface is mapped to the underlying substrate. Ordered particle arrays are useful for sensing and optics applications.
Fluid Transport and the Brain
Fluid Transport and the Brain
We are performing numerical and experimental studies of fluid transport in (and out of) the brain. Applications of this work are associated with serious conditions include Alzheimer's disease and hydrocephalus. An improved understanding of cerebral transport may contribute to improved treatment options.
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