PUBLICATIONS -
Peer-reviewed Papers, Review Articles and Book Chapters. (Past 5-years)
284. Melis A, Davies, FK, Chen Wintz, H-C, Zurbriggen A (2020) Production of β-phellandrene using genetically engineered photosynthetic microorganisms. U.S. Patent No. 10,563,228. (Issued February 18, 2020).
285. Betterle N, Hidalgo Martinez DA, Melis A (2020) Cyanobacterial production of biopharmaceutical and biotherapeutic proteins. Front. Plant Sci. 11:237. https://doi.org/10.3389/fpls.2020.00237
286. Hidalgo Martinez D, Payyavula RS, Kudithipudi C, Shen Y, Xu D, Warek U, Strickland JA, Melis A (2020) Genetic attenuation of alkaloids and nicotine content in tobacco (Nicotiana tabacum). Planta 251:92. https://doi.org/10.1007/s00425-020-03387-1
287. Valsami E-A, Psychogyiou ME, Pateraki A, Chrysoulaki E, Melis A, Ghanotakis DF (2020) Fusion constructs enhance heterologous β-phellandrene production in Synechocystis sp. PCC 6803. J. Appl. Phycol. 32:2889–2902.https://doi.org/10.1007/s10811-020-02186-1
288. Melis A, Formighieri C (2020) Fusion constructs as protein overexpression vectors. U.S. Patent No. 10,876,124 (issued December 29, 2020).
289. Melis A, Formighieri C (2021) Production of monoterpene blends by unicellular photosynthetic microorganisms U.S. Patent No. 10,889,835 (issued January 12, 2021.)
290. Lu YD, Gan QH, Iwai M, Alboresi A, Burlacot A, Dautermann O, Takahashi H, Crisanto T, Peltier G, Morosinotto T, Melis A, Niyogi K (2021) Role of an ancient light-harvesting protein of PSI in light absorption and photoprotection. Nature Comm 12:679. https://doi.org/10.1038/s41467-021-20967-1
291. Zhang XN, Betterle N, Hidalgo Martinez D, Melis A (2021) Recombinant protein stability in cyanobacteria. ACS Synth Biol. 10 (4): 810-825 https://dx.doi.org/10.1021/acssynbio.0c00610
292. Melis A (2021) Eukaryotic protein stability in cyanobacteria. Medicine Innovates – Breakthroughs. https://medicineinnovates.com/eukaryotic-protein-stability-cyanobacteria/
293. Valsami E-A, Pateraki A, Melis A, Ghanotakis DF (2021) Heterologous β-phellandrene production by alginate immobilized Synechocystis sp. PCC 6803. J Appl Phycol. 33:2157–2168 https://doi.org/10.1007/s10811-021-02451-x
294. Lu YD, Zhang X, Gu XP, Lin HZ, Melis A (2021) Engineering microalgae: transition from empirical design to programmable cells. Critical Rev. Biotech 41 (8):1233-1256. https://doi.org/10.1080/07388551.2021.1917507
295. Hidalgo Martinez D, Betterle N, Melis A (2022) Phycocyanin fusion constructs for heterologous protein expression accumulate as functional heterohexameric complexes in cyanobacteria. ACS Synth Biol. 11 (3), 1152–1166. https://doi.org/10.1021/acssynbio.1c00449
296. Melis A, Formighieri C (2022) Fusion constructs as protein overexpression vectors. Australia Patent 2016281666 (issued 8 December 2022).
297. Hidalgo Martinez D, Melis A (2023) Cyanobacterial phycobilisomes as a platform for the stable production of heterologous enzymes and other proteins. Metab Eng. 77:174-187 https://doi.org/10.1016/j.ymben.2023.04.002
298. Melis A, Hidalgo Martinez D, Betterle N (2023) Perspectives of cyanobacterial cell factories. Photosynth. Res. https://doi.org/10.1007/s11120-023-01056-4
299. Melis A, Formighieri C (2023) Production of monoterpene blends by unicellular photosynthetic microorganisms. Indian Patent No 462858 (Issued 27 October 2023).
300. Melis A, Formighieri C (2023) Production of monoterpene blends by unicellular photosynthetic microorganisms. Australian Patent # 2017269418 (Issued 04 January 2024).
301. Melis A, Formighieri C (2024) Fusion constructs as protein overexpression vectors. U.S. Patent No. 11,884,927 (issued January 30, 2024).
302. Melis A, Formighieri C (2024) Fusion constructs as protein over expression vectors. Indian Patent No. 511727 (issued February 16, 2024).
303. Majhi BK, Melis A (2024) Recombinant protein synthesis and isolation of human interferon alpha-2 in cyanobacteria. Bioresource Technology 400, 130664 https://doi.org/10.1016/j.biortech.2024.130664
304. Govindjee G, Sharkey TD, Melis A (2024) Honoring Hartmut Karl Lichtenthaler, innovative pioneer of photosynthesis, on his 90th birthday. Photosynthetica 62:326-338. DOI 10.32615/ps.2024.017
305. Majhi BK, Melis A (2025) Commentary. Recombinant protein synthesis and isolation of human interferon alpha-2 in cyanobacteria. Cell Signaling 2025;3(1):23-26. https://www.probiologists.com/article/recombinant-protein-synthesis-and-isolation-of-human-interferon-alpha-2-in-cyanobacteria
306. Majhi BK, Melis A (2025) Engineering Fibroblast Growth Factor-2 (FGF2) production in cyanobacteria. ACS Synth Biol.
INVITED SEMINARS AND LECTURES (Past 5-years)
193. 29th UC Davis Bodega Bay Marine Laboratory. Bodega Bay: First Plenary Lecture Presentation. Title: "Photosynthetic antenna engineering to improve crop yields.” Thursday, January 2, 2020
194. Michigan State University. Molecular Plant Science Seminar Series: Title: Photosynthetic antenna engineering to improve yields. Monday, September 14, 2020.
195. Biofuels Technology Club (BTC), a UC Berkeley Student Forum on Sustainability. Title: Terpenes and isoprenoids as renewable fuel and chemicals. Wednesday, October 28, 2020
196. International Conference on Algal Biomass, Biofuels & Bioproducts (ABBB 2021). Title: Recombinant protein stability in cyanobacteria. Presentation made remotely by Melis Lab Assistant Project Scientist Dr. Nico Betterle on June 14, 2021.
197. 60th Annual Meeting of the Phytochemicals Society of North America (PSNA 2021). Plenary Lecture Presentation. Title: Plant essential oils production in cyanobacteria. Friday, July 30, 2021.
198. USDA Agricultural Experiment Station Multistate Research Project NC1200, by ZOOM, project presentation. Title: Regulation of photosynthate partitioning. Saturday, November 20, 2021
199. Sandwalk Bio Ventures, Inc., by ZOOM, project presentation. Title: Unlocking the Synthetic Biology power of the sun. Thursday, June 9, 2022
200. USDA Agricultural Experiment Station Multistate Research Project NC1200, by ZOOM, project presentation. Title: Fusion constructs for heterologous protein expression in cyanobacteria. Saturday, November 19, 2022..