Selected Presentations

Lawson, T. G., Carmody, M., Zimmer*, J. T., Notarianni, T., Cushman*, C. H., and Sambel*, L. A. (2016) The ubiquitin-protein ligase E6AP/UBE3A catalyzes EMCV 3C protease ubiquitylation and supports early virus replication. (Annual Meeting of the American Society for Virology, Blacksburg, Virginia).

Notariana*, T., Carmody, M., Kirwin*, K., and Lawson, T. G. (2014) Identification of E6AP/UBE3A as a Ubiquitin-Protein Ligase that Catalyzes Encephalomyocarditis Virus 3C Protease Ubiquitylation (Annual Meeting of the American Society for Biochemistry and Molecular Biology, San Diego, California).

Lawson, T. G., Burke*, J. M., Nguyen*, T., and Carmody, M. (2013) Purification by affinity chromatography of the UbcH7-dependent ubiquitin protein-ligase that targets the EMCV 3C protease for ubiquitylation and degradation. (Annual Meeting of the American Society for Virology,State College, Pennsylvania).

Cohen*, L. C., Carmody, M., and Lawson, T. G. (2013) Delivery of EMCV 3C protease into cultured mouse cells by direct protein transfection. (Annual Meeting of the American Society for Virology,State College, Pennsylvania).

Lawson, T. G., Gustin, K. E., and Schlax, P. E. (2011) The Ubiquitin-conjugating Enzyme UbcH7 Is a Regulator of EMCV 3C Protease Concentration in Virus-infected Cells. (Annual Meeting of the American Society for Virology, Minneapolis, Minnesota).

Lawson, T. G. (2010) Modulation of Picornaviral 3C Protease Concentrations by Multiple Ubiquitylation Pathways. (Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona).

Lawson, T. G., and Schlax, P. E. (2009) A UbcH7-mediated Pathway Is Critical for the Conjugation of Ubiquitin to Picornaviral 3C Proteases. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, New Orleans, Louisiana).

Doi*, A, Fischer*, D. D., Schlax, P. E., and Lawson, T. G. (2007) N-terminal Ubiquitination of the Encephalomyocarditis Virus 3C Protease. FASEB J. 21, 1020. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, Washington, D. C.).

Doi*, A. and Lawson, T. G. (2006) Evidence for Secondary Structure-mediated Down-regulation of EMCV 3D RNA Polymerase Gene Transcription. (33rd Maine Biological and Biomedical Sciences Symposium, MDI Biological Laboratory, Salisbury Cove, Maine).

Zhang*, J., Unger*, K., and Lawson, T. G. (2006) Evaluation of the Role of the N-terminal Amino Acid in HAV 3C Protease Susceptibility to Ubiquitination. (33rd Maine Biological and Biomedical Sciences Symposium, MDI Biological Laboratory, Salisbury Cove, Maine).

Lawson, T. G. (2005) Pathways to Picornaviral Protease Destruction. (Nineteenth Symposium of the Protein Society, Boston, Massachusetts).

Lawson, T. G. and Schlax, P. E. (2005) Picornavirus 3C Proteases are targeted by multiple ubiquitin-conjugating pathways. (32nd Maine Biological and Biomedical Sciences Symposium, MDI Biological Laboratory, Salsbury Cove, Maine).

Schlax, P. E., Planchart, A., Abrahamsen, L. H., and Lawson, T. G. (2004) Evidence of a role for the ubiquitin/26S proteasome system in the rapid turnover of EMCV 3C protease in vivo. (Annual Meeting of the American Society for Virology, Montreal, Quebec, Canada).

Fischer*, D. D., Schlax, P. E., and Lawson, T. G. (2004) Ubiquitination of the encephalomyocarditis virus 3C protease by a Ubc5a-dependent E3 ubiquitin-protein ligase. (Annual Meeting of the American Society for Virology, Montreal, Quebec, Canada).

Lawson, T. G., Weaver*, G. W., and Schlax, P. E. (2003) Recognition of the Hepatitis A Virus 3D RNA Polymerase by the Ubiquitin/26S Proteasome System. FASEB J. 17, 996. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, San Diego, California).

Ricaldez*, E. X., Schlax, P. E., Barlow*, J. R., and Lawson, T. G. (2003) Evaluation of the Hepatitis A Virus 3D RNA Polymerase Purified from Expressing E. coli cells as a Substrate for Ubiquitination. FASEB J. 17, 996. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, San Diego, California).

Losick*, V. P., Schlax, P. E., Emmons*, R., and Lawson, T. G. (2001) A Signal in the Hepatitis A Virus 3C Protease Recognized by the Ubiquitin-Mediated Proteolytic System. (Annual Meeting of the American Society for Virology, Madison, Wisconsin).

Sweep*, M. E., Edmonds*, J. H., Lawson, T. G., and Haas, A. L. (1999) Kinetic Analysis of the E3alpha-Dependent Ubiquitination of Picornavirus 3C Proteases. FASEB J. 13, 1484. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, San Francisco, California).

Lawson, T. G., Emmons*, R. A., Gronros, D. G., and Dow*, M. A. (1999) Transferable Protein Destruction Signals in Picornavirus 3C Proteases. FASEB J. 13, 1484. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, San Francisco, California).

Evans*, P. E., Bastien*, M. C., Pickart, C. M., and Lawson, T. G. (1998) Identification and Purification of an E3 Ubiquitin-Protein Ligase that Recognizes the EMC Virus 3C Protease as a Substrate. FASEB J. 12, 1435. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, Washington, D. C.).

Lawson, T. G., Gronros, D. L., Gladding*, R. L., and Michalewich*, K. M. (1997) Mapping a Signal in the Encephalomyocarditis Virus 3C Protease which Is Required for Conjugation with Ubiquitin. (FASEB Summer Research Conference on Ubiquitin and Protein Degradation, Saxtons River, Vermont).

Lawson, T. G., Michalewich*, K. M., Clark*, J. K., and Gronros, D. L. (1996) Mapping Ubiquitin Attachment Sites in the Encephalomyocarditis Virus 3C Protease. (Annual Meeting of the American Society for Virology, London, Ontario, Canada).

Lawson, T. G., Haas*, A. L., Gronros, D. L., Oliver*, C. J., and McPartland*, J. P. (1995) Evaluation of the Poliovirus 3C Protease as a Potential Substrate for Ubiquitin-Mediated Proteolysis. FASEB J. 9, 1472. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, San Francisco, California).

Lawson, T. G., Wey*, A. C., Gronros, D. L., Werner*, J. A., and Lockhart*, J. L. (1994) Evidence that the EMC Virus 3C Protease Is a Substrate for Conjugation with Ubiquitin. FASEB J. 8, 1316. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, Washington, D. C.).

Lawson, T. G., Gollan*, T. J., DiGeorge*, A. M., and Oberst*, M. D. (1993) The Selective ATP-Dependent, Ubiquitin-Stimulated Degradation of the Encephalomyocarditis Virus 3C Protease in vitro. (FASEB Summer Research Conference on Ubiquitin and Protein Degradation, Saxtons River, Vermont).

Lawson, T. G., Gollan*, T. J., and Oberst*, M. D. (1992) An ATP-Dependent Proteolytic System which Rapidly and Selectively Degrades the Encephalomyocarditis Virus 3C Protease in vitro. (Ninth International ICOP Conference on Proteolysis and Protein Turnover, Williamsburg, Virginia).

Lawson, T. G., Oberst*, M. D., Gupta*, M., Peura*, S. R., and Zydlewski*, J. D. (1991) The Rapid and Selective Degradation of the Encephalomyocarditis Virus 3C Protease in Reticulocyte Lysate. (Annual Meeting of the American Society for Virology, Fort Collins, Colorado).

Lawson, T. G., Oberst*, M. D., Gupta*, M., Peura*, S. R., and Zydlewski*, J. D. (1991) Characterization of the Rapid Degradation of the Encephalomyocarditis Virus 3C Protease in Reticulocyte Lysate. FASEB J. 5, 1178. (Annual Meeting of the Federation of American Societies for Experimental Biology, Atlanta, Georgia).

Lawson, T. G., Smith, L. L., Palmenberg, A. C., and Thach, R. E. (1989) Inducible Expression of the Encephalomyocarditis Virus 3C Protease in Stably Transformed Mouse Cell Lines. (Annual Meeting of the American Society for Virology, London, Ontario, Canada).

Lawson, T. G., Cladaras, M. H., Ray, B. K., Lee, K. A., Abramson, R. D., Merrick, W. C., and Thach, R. E. (1987) The Unwinding of mRNA Structure by Eukaryotic Initiation Factors 4F, 4A, and 4B, and the Role of mRNA Structure in Determining Translation Rates. (Cold Spring Harbor Symposium on Translational Control, Cold Spring Harbor Laboratory, New York.)

Lawson, T. G., Cladaras, M. H., Ray, B. K., Lee, K. A., Abramson, R. D., Merrick, W. C., and Thach, R. E. (1987) Discrimination Among Reovirus mRNAs by Eukaryotic Initiation Factors 4F Plus 4A: The Roles of Cap Accessibility and 5' Proximal Secondary Structure. (Annual Meeting of the American Society for Virology, Chapel Hill, North Carolina and the VIIth International Congress of Virology, Edmonton, Alberta, Canada).

Thach, R. E., Lawson, T. G., Lee, K. A., Abramson, R. D., and Merrick, W. C. (1987) Dissociation of 5' Proximal Helical Regions in Messenger RNA by Eukaryotic Initiation Factors 4F, 4A, and 4B. Fed. Proc. 46, 2185. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, Philadephia, Pennsylvania).

Rychlik, W., Lawson, T. G., Hagedorn, C. H., Thach, R. E., and Rhoads, R. E. (1987) Phosphorylation of Eukaryotic Initiation Factor eIF-4E. Fed Proc. 46, 2185. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, Philadelphia, Pennsylvania).

Lawson, T. G., Ray, B. K., Grifo, J. A., Abramson, R. D., Merrick, W. C., Betsch, D. F., Weith, H. L., and Thach, R. E. (1986) Influence of 5' Proximal Secondary Structure on the Translational Efficiency of Eukaryotic mRNAs and on Their Interaction with Initiation Factors. (European Molecular Biology Organization Workshop on Eukaryotic Protein Synthesis, Patras, Greece).

Lawson, T. G., Ray, B. K., Abramson, R. D., Merrick, W. C., and Thach, R. E. (1986) Effect of Secondary Structure on Eukaryotic mRNA Translation and Its Unwinding by Initiation Factors. in Current Communications in Molecular Biology: Translational Control, ed. Matthews, M. B. (Cold Spring Harbor Laboratory), pp 25-29.

Abramson, R. D., Dever, T. E., Ray, B. K., Lawson, T. G., Thach, R. E., and Merrick, W. C. (1986) Binding of Initiation Factors to mRNA. Fed. Proc. 45, 1678. (Annual Meeting of the American Society for Biochemistry and Molecular Biology, Washington, D. C.).

Lawson, T. G., Cladaras, M. H., Ray, B. K., Thach, R. E. (1985) Influence of Reoviral mRNA Structure on Translational Efficiency. (Annual Meeting of the American Society for Virology, Albuquerque, New Mexico).

Lawson, T. G. and Weith, H. L. (1984) Characterization of the Activity of E. coli Ribonuclease H and Use in RNA Secondary Structure Analysis.  Fed. Proc. 43, 1885.  (Annual Meeting of the American Society for Biochemistry and Molecular Biology, St. Louis, Missouri).

(*undergraduate students)