Fundamental Literature

Biamidine Transfer and Applications - Biguanides

Synthesis:

1. Synthetic Accesses to Biguanide Compounds
   https://www.beilstein-journals.org/bjoc/articles/17/82?T=y 

2. Mild Biamidine-Transfer Conditions for the Synthesis of Aliphatic Biguanides
   https://www.thieme-connect.com/products/ejournals/html/10.1055/a-1681-4544 

Mechanisms of Action:

1. The Mechanism of Action of Biguanides: New Answers to a Complex Question
   https://www.mdpi.com/2072-6694/14/13/3220 

2. Biguanides drugs: Past success stories and promising future for drug discovery
   https://www.sciencedirect.com/science/article/abs/pii/S0223523421005754 

Application:

1. Incorporation of a Biguanide Scaffold Enhances Drug Uptake by Organic Cation Transporters 1 and 2
   https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.7b00285  pdf 

2. Therapeutic Repurposing of Biguanides in Cancer
   https://www.cell.com/trends/cancer/abstract/S2405-8033(21)00064-9 pdf 

3. Biguanide-Vancomycin Conjugates are Effective Broad-Spectrum Antibiotics against Actively Growing and Biofilm-Associated Gram-Positive and Gram-Negative ESKAPE Pathogens and Mycobacteria
   https://pubs.acs.org/doi/10.1021/jacs.4c06520 pdf