EDUCATION 

2006 - 2013    Ph.D. in Biological Sciences, Seoul National University (Advisor: Dr. Kyungjin Kim) 

2002 - 2006     B.S. in Biological Sciences, Seoul National University 

PROFESSIONAL EXPERIENCES 

Jul 2020 – Jan 2021      Staff Scientist, Fred Hutchinson Cancer Research Center, Seattle, WA (Supervisor: Dr. Linda B. Buck) 

Oct 2013 - Jul 2020      Research Associate, Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 

                                                   (Supervisor: Dr. Linda B. Buck) 

Mar 2013 - Sep 2013    Post-doctoral Fellow, Seoul National University (Supervisor: Dr. Kyungjin Kim) 

EDUCATION 

1994 - 1998 경북대 생물학과 학사

1998 - 2000 경북대 생물학과 석사 

2005 - 2009 아주대 의과대학 박사

PUBLICATION

Park SJ, Kim KW*, Lee EJ* (2025) Gut-brain axis and environmental factors in Parkinson's disease: bidirectional link between disease onset and progression. Neural Regen Res 20, 3416  (* Corresponding authors)

Roh Y, Kim H, Kim EA, Ji K, Kang M, Gong D, Im S, Hong I, Park J, Park SJ, Bae Y, Park JI, Koh JS, Han S, Lee EJ*, Kang D* (2024) Transient shuttle of a widespread neural robe with minimal perturbation. Npj Flex Electron 8, 40 (* Corresponding authors)

Jeong A , Park SJ, Lee EJ*, Kim KW* (2024) Nanoplastics exacerbate Parkinson's disease symptoms in C. elegans and human cells. J Hazard Mater 465, 133289 (* Corresponding authors)

Park SJ, Kim H, Kim SH, Joe EH, Jou I (2019) Epigenetic downregulation of STAT6 increases HIF-1α expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells. Acta Neuropathol Commun 7, 149

Lee JH, Kim H, Park SJ, Woo JH, Joe EH, Jou I (2016) Small heterodimer partner SHP mediates liver X receptor (LXR)-dependent suppression of inflammatory signaling by promoting LXR SUMOylation specifically in astrocytes. Sci Signal 9, ra78

Woo JH, Lee JH, Kim H, Park SJ, Joe EH, Jou I (2015) Control of Inflammatory Responses: a New Paradigm for the Treatment of Chronic Neuronal Diseases. Exp Neurobiol 24, 95

Park SJ, Lee JH, Kim HY, Choi YH, Park JS, Suh YH, Park SM, Joe EH, Jou I (2012) Astrocytes, but not microglia, rapidly sense H₂O₂via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release. J Immunol 188, 5132

Yun JH*, Park SJ*, Jo A, Kang JL, Jou I, Park JS, Choi YH (2011) Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes. Exp Mol Med 43, 660 (*Equal contribution)

Kook KH, Choi YH, Kim YR, Park SJ, Jou I, Kim SJ, Lee SY (2011) Altered ganglioside expression modulates the pathogenic mechanism of thyroid-associated ophthalmopathy by increase in hyaluronic acid. Invest Ophthalmol Vis Sci 52, 264

Kim H, Choi YH, Park SJ, Lee SY, Kim SJ, Jou I, Kook KH (2010) Antifibrotic effect of Pirfenidone on orbital fibroblasts of patients with thyroid-associated ophthalmopathy by decreasing TIMP-1 and collagen levels. Invest Ophthalmol Vis Sci 51, 3061

Lee JH, Park SM, Kim OS, Lee CS, Woo JH, Park SJ, Joe EH, Jou I (2009) Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes. Mol Cell 35, 806

Park SJ, Kim HY, Kim H, Park SM, Joe EH, Jou I, Choi YH (2009) Oxidative stress induces lipid-raft-mediated activation of Src homology 2 domain-containing protein-tyrosine phosphatase 2 in astrocytes. Free Radic Biol Med 46, 1694

Kim HY, Park SJ, Joe EH, Jou I (2006) Raft-mediated Src homology 2 domain-containing proteintyrosine phosphatase 2 (SHP-2) regulation in microglia. J Biol Chem 281, 11872

EDUCATION 

2007 - 2013 순천향대학교 의료생명공학과 학사 

2014 - 2016 순천향대학교 의약바이오학과 석사 

2016 - 2021 충남대학교 분자생명공학과 박사

2021 - 2022 아주대학교 의과대학 연구강사

2022 - 2024 아주대학교 AI-초융합 KIURI 질환극복 중개연구단

2024 - 2027 세종 과학 펠로우

PUBLICATION

Lee J, Lee H, Lee H, Shin M, Shin MG , Seo J, Lee EJ, Park SA, Park  S (2023) ANKS1A regulates LDL receptor-related protein 1 (LRP1)- mediated cerebrovascular clearance in brain endothelial cells. Nat Commun 14, 8463

Shin MG,  Bae Y, Afzal R, Kondoh K, Lee EJ (2023) Olfactory modulation of stress-response neural circuits. Exp Mol Med 55, 1659

Lee YH, Kim YB, Kim KS, Jang M, Song HY, Jung SH, Ha DS, Park JS, Lee J, Kim KM, Cheon DH, Baek I, Shin MG, Lee EJ, Kim SJ, Choi HJ (2023) Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice. Nat Commun 14, 1486

Jeong JH, Han JS, Jung Y, Lee SM, Park SH, Park M, Shin MG, Kim N, Kang MS, Kim S, Lee KP, Kwon KS, Kim CA, Yang YR, Hwang GS, Kwon ES (2023) A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity. Nat Commun 14:288

Shin MG, Lee JW, Han JS, Lee B, Jeong JH, Park SH, Kim JH, Jang S, Park M, Kim SY, Kim S, Yang YR, Kim JY, Hoe KL, Park C, Lee KP, Kwon KS, Kwon ES (2020) Bacteriaderived metabolite, methylglyoxal, modulates the longevity of C. elegans through TORC2/SGK1/DAF-16 signaling. Proc Natl Acad Sci U S A 17, 17142 

PUBLICATION

Junaid M, Bae Y, Choe HK,  Kondoh K, Lee EJ*, Lim SB* (2025) Deciphering molecular inputs to CRH neurons from POMC neurons. Fundam Res in press  (* Corresponding authors)

Roh Y, Kim H, Kim EA, Ji K, Kang M, Gong D, Im S, Hong I, Park J, Park SJ, Bae Y, Park JI, Koh JS, Han S, Lee EJ*, Kang D* (2024) Transient shuttle of a widespread neural robe with minimal perturbation. Npj Flex Electron under revision (* Corresponding authors)

Shin MG,  Bae Y, Afzal R, Kondoh K, Lee EJ (2023) Olfactory modulation of stress-response neural circuits. Exp Mol Med 55, 1659

AWARDS

April 2019 | Clean Tech Competition | Certificate of Achievement for competing in the Finals of the 2019 Spellman High Voltage Electronics Clean Tech Competition “Toward A Greener Tomorrow” - Mitigating the Effects of Climate Change Category