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Dr. Prabhakar Singh's research focuses on the morphological and molecular mechanisms underlying neurodegenerative diseases, particularly Alzheimer's disease, ischemia, and cognitive dysfunction associated with obstructive sleep apnea. His work aims to unravel the complex pathways that lead to neuronal degeneration and cognitive impairments, with the goal of identifying potential therapeutic targets.
Dr. Prabhakar Singh's research focuses on the morphological and molecular mechanisms underlying neurodegenerative diseases, particularly Alzheimer's disease, ischemia, and cognitive dysfunction associated with obstructive sleep apnea. His work aims to unravel the complex pathways that lead to neuronal degeneration and cognitive impairments, with the goal of identifying potential therapeutic targets.
Research Projects
Research Projects
- Development of animal model of cholinergic degeneration and therapeutic interventions for Alzheimer’s disease (P.I., ICMR, Rs. 35 Lakh)
- Neurological outcomes of obstructive sleep apnea and its cross generational cognitive effects in animal models (P.I., CSRI DST, Rs. ~85 Lakh)
- Regional differences of transient focal brain ischemia in animal models (using stereotaxic injection of natural vasoconstrictor, endothelin-1) (P.I., AIIMS).
- Developing a methodology to investigate cellular interaction of mucor in human tissue human tissue at ultrastructure level using electron microscopy (P.I., AIIMS).
- Effect of Transplantation of lentivirus mediated genetically engineered mesenchymal stem cells into monocrotaline induced pulmonary hypertensive rats: validation by Next Generation Sequencing (P.I., with Department of Pharmacology, Rs. 20 Lakh, AIIMS)
Collaborative:
Collaborative:
Development of a nanoparticle-based delivery system of Cisplatin for tissue-specific targeted drug delivery vehicles (AIIMS) (Co-Investigator, ICMR)
Development of a nanoparticle-based delivery system of Cisplatin for tissue-specific targeted drug delivery vehicles (AIIMS) (Co-Investigator, ICMR)
Study of the age-related changes in axonal cytoskeleton of the rat optic nerve (AIIMS) (Co-Investigator, ICMR)
Study of the age-related changes in axonal cytoskeleton of the rat optic nerve (AIIMS) (Co-Investigator, ICMR)
Nanoparticles and their applications.
Nanoparticles and their applications.
Cell biology and autophagy (JMI, Delhi and MNNIT Allahabad)
Cell biology and autophagy (JMI, Delhi and MNNIT Allahabad)
Ultrastructural studies of neuronal development and regeneration (IGIB, Delhi).
Ultrastructural studies of neuronal development and regeneration (IGIB, Delhi).
Research Infrastructure
Research Infrastructure
Advanced Microscopy
Advanced Microscopy
- Transmission Electron Microscope (Talos 200kV) (DST-SAIF)
- Scanning electron microscope (SEM), cryo-SEM with EDS (AIIMS, DBT-SAHAJ)
- Super-resolution microscope (Elyra 7, Carl Zeiss) (DST-SAIF)
- Confocal Microscope (AIIMS)
- Stereology (departmental facility)
- Phase contrast Bright Field and Fluorescence microscopes (Nikon, Olympus, Zeiss, Leica)
- Atomic Force Microscope for life science (Bio-AFM, Bruker)
Analytical Instrumentation
Analytical Instrumentation
- Ultracentrifuge (AIIMS)
- HPLC and FPLC (AIIMS)
- Multi-Mode Microplate Reader (BioTek Synergy H1)
- Real-Time PCR (Bio-Rad)
Experimental Model
Experimental Model
- Stereotactic instrument for rodent brain surgery
- Intermittent Hypoxia System for small animals (DST-CSRI funded facility)
- Animal Behavioral Facility
- Cell culture facility of EMF
Education and Training
Education and Training
Involved with graduate and post-graduate education and various electron microscopy-related training programs. For information regarding training programs visit: https://saifaiims.com
Involved with graduate and post-graduate education and various electron microscopy-related training programs. For information regarding training programs visit: https://saifaiims.com
Scanning Electron Micrograph of the surface of the lateral ventricle in a rat brain, highlighting ependymal cilia.
Confocal micrographs of GFAP-positive astrocytes in the hippocampus of control and amyloid beta-injected AD model.
Infrastructure Under-Development
Infrastructure Under-Development
- 3D electron microscopy facility (Funded by DBT SAHAJ)
- X-Ray Microscope (10 crores, Funded by DST, expected installation 2025)
- CryoEM 300KV (AIIMS/Ministry of Health and Family Welfare, Govt. of India)
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