Research & Professional Achievements
Research & Professional Achievements
My research focuses on the molecular mechanisms of cardiac protection against ischaemia/reperfusion injury, with particular emphasis on the role of Peroxisome Proliferator-Activated Receptors (PPARs) in cardioprotection. Part of my work has investigated the non-metabolic pleiotropic properties of PPARs in the heart, including their capacity to suppress oxidative stress-induced apoptosis, modulate matrix metalloproteinase expression, and regulate Bcl-2 family proteins in cardiac myocytes.
Barlaka E., Galatou E., Mellidis K., Ravingerova T., Lazou A. (2016). Role of Pleiotropic Properties of Peroxisome Proliferator-Activated Receptors in the Heart: Focus on the Nonmetabolic Effects in Cardiac Protection. Cardiovasc Ther. 34(1):37-48.
Barlaka E., Ledvényiová V., Galatou E., Ferko M., Čarnická S., Ravingerová T., Lazou A. (2013). “Delayed” cardioprotective effects of WY-14643 are associated with inhibition of MMP-2 and modulation of Bcl-2 family proteins through PPAR-alpha activation in rat hearts subjected to global ischaemia/reperfusion. Canadian Journal of Physiology and Pharmacology. 91(8):608-16.
Ravingerová T., Čarnická S., Ledvényiová V., Barlaka E., Galatou E., Chytilová A., Mandíková P., Nemčeková M., Adameová A., Kolář F., Lazou A. (2013). Upregulation of genes involved in cardiac metabolism enhances myocardial resistance to ischemia/reperfusion in the rat heart. Physiological Research. 12;62 Suppl 1:S151-63.