Publications

Full publication list on ORCID

• Tkachev, V., Vanderbeck, A., Perkey, E., Furlan, S., McGuckin, C., Gómez Atria, D., Gerdemann, U., Rui, X., Lane, J., Hunt, D.J., Zheng, H., Colonna, L.; Hoffman, M., Yu, A., Outen, R., Kelly, S., Allman, A., Koch, U., Radtke, F. , Ludewig, B., Burbach, B., Shimizu, Y., Panoskaltsis-Mortari, A., Chen, G., Carpenter, S.M., Harari, O., Kuhnert, F., Thurston, G., Blazar, B.R., Kean, L.S., Maillard, I. Evolutionarily conserved effects of Notch signaling drive the pathogenesis of acute intestinal graft-versus-host disease in mice and non-human primates. Sci. Transl. Med. 2023; 15:eadd1175.

• Burbach, B.J., O’Flanagan, S.D., Shao, Q., Young, K.M., Slaughter, J.R., Rollins, M.R., Street, T.L., Granger, V.E., Beura, L.K., Azarin, S.M., Ramadhyani, S., Forsyth, B.R., Bischof, J.C., Shimizu, Y.: Irreversible electroporation augments checkpoint immunotherapy and promotes tumor antigen-specific tissue-resident memory CD8+ T cells. Nat. Commun. 2021; 12:3862. https://doi.org/10.1038/s41467-021-24132-6 

• Anderson, K.L., Snyder, K.M., Ito, D., Lins, D.C., Mills, L.J., Weiskopf, K., Ring, N.G., Ring, A.M., Shimizu, Y., Mescher, M.F., Weissman, I.L., Modiano, J.F.: Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade. Melanoma Res. 2019; 30(2):147-158.

• Shao, Q., O’Flanagan, S., Lam, T., Roy, P., Pelaez, F., Burbach, B.J., Azarin, S.M., Shimizu, Y., Bischof, J.C.: Engineering T cell response to cancer antigens by choice of focal therapeutic conditions. Int. J. Hyperthermia  2019; 1-9. doi: 10.1080/02656736.2018.1539253.

• Foss, J.D., Fiege, J., Shimizu, Y., Collister, J.P., Mayerhofer, T., Wood, L., and Osborn, J.W.: Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats. Physiol. Rep. 2018; 6:doi: 10.14814/phys2.13602.

• Domae, E., Hirai, Y., Ikeo, T., Goda, S., and Shimizu, Y.: Cytokine-mediated activation of human ex vivo-expanded Vgamma9Vdelta2 T cells. Oncotarget 2017; 8:45928-45942.

• Banek, C.T., Kneupfer, M.M., Foss, J.D., Fiege, J.K., Asirvatham-Jeyaraj, N., Van Helden, D., Shimizu, Y., and Osborn, J.W. Resting afferent renal nerve discharge and renal inflammation: elucidating the role of afferent and efferent renal nerves in deoxycorticosterone acetate salt hypertension. Hypertension 2016; 68:1415-1423.

• Asirvatham-Jeyaraj, N., Fiege, J.K., Han, R., Foss, J., Banek, C.T., Burbach, B.J., Razzoli, M., Bartolomucci, A., Shimizu, Y., Panoskaltsis-Mortari, A., and Osborn, J.W.: Renal denervation normalizes arterial pressure with no effect on glucose metabolism or renal inflammation in obese hypertensive mice. Hypertension 2016; 68:929-936.

• Fiege, J.K., Beura, L.K., Burbach, B.J., and Shimizu, Y.: Adhesion and degranulation promoting adapter protein (ADAP) promotes CD8 T cell differentiation and resident memory formation and function during an acute infection. J. Immunol. 2016; 197:2079-2089.

• Wang, H., Kwak, D., Fassett, J., Hou, L., Xu, X., Burbach, B., Thenappan, T., Xu, Y., Ge, J., Shimizu, Y., Bache, R., and Chen, Y.: CD28/B7 deficiency attenuates systolic overload-induced congestive heart failure, myocardial and pulmonary inflammation, and activated T-cell accumulation in the heart and lungs. Hypertension 2016; 68:688-696.

• Fiege, J.K., Burbach, B.J. and Shimizu, Y.: Negative regulation of memory phenotype CD8 T cell conversion by adhesion and degranulation promoting adapter protein (ADAP). J. Immunol. 2015; 195:3119-3128.

• Zumwalde, N.A., Domae, E., Mescher, M.F. and Shimizu, Y.: ICAM-1 dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation. J. Immunol. 2013; 191:3683-3693.

• Mitchell, J.S., Burbach, B.J., Srivastava, R., Fife, B.T. and Shimizu, Y.: Multi-stage T cell-dendritic cell interactions control optimal CD4 T cell activation through the ADAP-SKAP55 signaling module. J. Immunol. 2013; 191:2372-2383.

• Srivastava, R., Burbach, B.J., Mitchell, J.S., Pagan, A.J. and Shimizu, Y.: ADAP regulates cell cycle progression of T cells via control of cyclin E and cdk2 expression through distinct CARMA-dependent signaling pathways. Mol. Cell. Biol. 2012; 32:1907-1918.

• Bunnell, T.M., Burbach, B.J., Shimizu, Y. and Ervasti, J.M.: b-actin specifically controls cell growth, migration, and the G-actin pool. Mol. Biol. Cell 2011; 22:4047-4058.

• Burbach, B.J., Srivastava, R., Ingram, M.A., Mitchell, J.S. and Shimizu, Y.: The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kB activation. J. Immunol. 2011; 186:6227-6237.

• DeNucci, C.C. and Shimizu, Y.: b1 integrin is critical for the maintenance of Listeria monocytogenes-specific CD4 T cells in the bone marrow but not long-term immunological memory. J. Immunol. 2011; 186:4019-4026.

• Srivastava, R., Burbach, B.J. and Shimizu, Y.: NF-kB activation in T cells requires discrete control of IkBkinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein. J. Biol. Chem. 2010; 285:11100-11105.

• DeNucci, C.C., Pagan, A.J., Mitchell, J.S. and Shimizu, Y.: Control of alpha4beta7 integrin expression and T cell homing by the beta1 integrin subunit. J. Immunol. 2010; 184:2458-2467.

• DeNucci, C.C., Mitchell, J.S. and Shimizu, Y.: Integrin function in T cell homing to lymphoid and non-lymphoid sites: getting there and staying there. Crit. Rev. Immunol. 2009; 29:87-109.

• Burbach, B.J., Srivastava, R., Medeiros, R.B., O'Gorman, W.E., Peterson, E.J. and Shimizu, Y.: Distinct regulation of integrin-dependent T cell conjugate formation and NF-kB activation by the adapter protein ADAP. J. Immunol. 2008; 181:4840-4851.

• Nolz, J.C., Nacusi, L.P., Segovis, C.M., Medeiros, R.B., Mitchell, J.S., Shimizu, Y. and Billadeau, D.D.: The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activated of Rap1. J. Cell Biol. 2008; 182:1231-1244.

• Thomas, M.S., Mitchell, J.S., DeNucci, C.C., Martin, A.L. and Shimizu, Y.: The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites. J. Leukoc. Biol. 2008; 84:814-823.

• Martin, A.L., Schwartz, M.D., Jameson, S.C. and Shimizu, Y.: Selective regulation of CD8 effector T cell migration by the p110gamma isoform of phosphatidylinositol 3-kinase (PI 3-K). J. Immunol. 2008; 180:2081-2088.

• Mueller, K.L., Thomas, M.S., Burbach, B.J., Peterson, E.J. and Shimizu, Y.: Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival. J. Immunol. 2007; 179:3559-3569.

• Nolz, J.C., Medeiros, R.B., Mitchell, J.S., Zhu, P., Freedman, B.D., Shimizu, Y. and Billadeau, D.D.: WAVE2 recruits vinculin and talin to generate high affinity integrin binding at the immunological synapse. Mol. Cell. Biol. 2007: 27:5986-6000.

• Medeiros, R.B., Burbach, B.J., Mueller, K.L., Srivastava, R., Moon, J.J., Highfill, S., Peterson, E.J. and Shimizu, Y.: Regulation of NF-kB activation in T cells via association of the adapter proteins ADAP and CARMA1. Science 2007; 316:754-758.

• Burbach, B.J., Medeiros, R.B., Mueller, K.L. and Shimizu, Y.: T cell receptor signaling to integrins. Immunol. Rev. 2007; 218:65-81.

• Fischer, U.B., Jacovetty, E.L., Medeiros, R.B., Goudy, B.D., Zell, T., Swanson, J.-B., Lorez, E., Shimizu, Y., Miller, M.J., Khoruts, A. and Ingulli, E.: MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo. Proc. Natl. Acad. Sci. USA 2007; 104:7181-7186.

• Gomez, T.S., Kumar, K., Medeiros, R.B., Shimizu, Y., Leibson, P.J. and Billadeau, D.D.: Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity 2007; 26:177-190.

• Goda, S., Inoue, H., Umehara, H., Miyaji, M., Nagano, Y., Harakawa, N., Imai, H., Lee, P., McCarthy, J.B., Ikeo, T., Domae, N., Shimizu, Y. and Iida, J.: Matrix metalloproteinase-1 produced by human CXCL12-stimulated NK cells. Am. J. Pathol. 2006; 169:445-458.

• Fostel, L.V., Dluzniewska, J., Shimizu, Y., Burbach, B.J. and Peterson, E.J.: ADAP is dispensable for natural killer cell development and function. Int. Immunol. 2006; 18:1305-1314.

• George, T.C., Fanning, S.L., Fitzgerald-Bocarsly, P., Medeiros, R.B., Highfill, S., Shimizu, Y., Hall, B.E., Frost, K., Basiji, D., Ortyn, W.E., Morrissey, P.J. and Lynch, D.H.: Quantitative measurement of nuclear translocation events using similarity analysis of multispectral cellular images obtained in flow. J. Immunol. Methods 2006; 311:117-129.

• Nolz, J.C., Gomez, T.S., Zhu, P., Li, S., Medeiros, R.B., Shimizu, Y., Burkhardt, J.K., Freedman, B.D. and Billadeau, D.D.: WAVE2 regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Curr. Biol. 2006; 16:24-34.

• Finkelstein, L.D., Shimizu, Y. and Schwartzberg, P.L. Tec kinases regulate T cell receptor-mediated recruitment of signaling molecules and integrin-dependent cell adhesion. J. Immunol. 2005; 175:5923-5930.

• Medeiros, R.B., Dickey, D.M., Chung, H., Quale, A.C., Nagarajan, L.R., Billadeau, D.B. and Shimizu, Y.: Protein kinase D1 and the beta1 integrin cytoplasmic domain control beta1 integrin function via regulation of Rap1 activation. Immunity 2005; 23:213-226.

• Rosenthal-Allieri, M.A., Ticchioni, M., Breittmayer, J.P., Shimizu, Y. and Bernard, A.: Influence of beta1 integrin intracytoplasmic domains in the regulation of VLA-4-mediated adhesion of human T cells to VCAM-1 under flow conditions. J. Immunol. 2005; 175:1214-1223.

• Mueller, K.L., Daniels, M.A., Felthauser, A., Kao, C., Jameson, S.C. and Shimizu, Y.: Cutting edge: LFA-1 integrin-dependent T cell adhesion is regulated by both Ag specificity and sensitivity. J. Immunol. 2004; 173:2222-2226.

• Goda, S., Quale, A.C., Woods, M.L., Felthauser, A. and Shimizu, Y.: Control of T cell receptor-mediated activation of beta1 integrins by the ZAP-70 interdomain B region and the LAT adapter protein. J. Immunol. 2004; 172:5379-5387.

• Pribila, J.T., Itano, A.A., Mueller, K.L. and Shimizu, Y.: The alpha1beta1 and alphaEbeta7 integrins define a subset of dendritic cells in peripheral lymph nodes with unique adhesive and antigen uptake properties. J. Immunol. 2004:172:282-291.

• Pribila, J.T., Quale, A.C., Mueller, K.L. and Shimizu, Y.: Integrins and T cell-mediated immunity. Annu. Rev. Immunol. 2004; 22:157-180.

• Pribila, J.T. and Shimizu, Y.: Signal transduction events regulating integrin function and T cell migration: new functions and complexity. Immunol. Res. 2003:27:107-128.

• Kellermann, S.-A., Dell, C.L., Hunt, S.W., III and Shimizu, Y.: Genetic analysis of integrin activation in T lymphocytes. Immunol. Rev. 2002; 186:172-188.

• Peterson, E.J., Woods, M.L., Dmowski, S.A., Derimanov, G. Jordan, M.S., Wu, J.N., Myung, P.S., Liu, Q.-H., Pribila, J.T., Freedman, B.S., Shimizu, Y. and Koretzky, G.A.: Coupling of the TCR to integrin activation by SLAP-130/Fyb. Science 2001; 293:2263-2265.

• Ottoson, N.C., Pribila, J.T., Chan, A.S.H. and Shimizu, Y.: Cutting edge: T cell migration regulated by CXCR4 chemokine receptor signaling to ZAP-70 tyrosine kinase. J. Immunol. 2001; 167:1857-1861.

• Woods, M.L. and Shimizu, Y.: Signaling networks regulating beta1 integrin-mediated adhesion of T lymphocytes to the extracellular matrix. J. Leukoc. Biol. 2001; 69:874-880.

• Chen, R., Kim, O., Li, M., Ilic, D., Xiong, X., Guan, J.-L., Kung, H.-J., Chen, H., Damsky, C., Shimizu, Y. and Qiu, Y.: Regulation of a PH domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat. Cell Biol. 2001; 3:439-444.

• Woods, M.L., Kivens, W.J., Adelsman, M.A., Qiu, Y., August, A. and Shimizu, Y.: A novel function for the Tec family tyrosine kinase Itk in activation of beta1 integrins by the T cell receptor. EMBO J. 2001; 20:1232-1244.

• Epler, J.A., Liu, R., Chung, H., Ottoson, N.C. and Shimizu, Y.: Regulation of beta1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity. J. Immunol. 2000; 165:4941-4949.

• Hunter, A.J., Ottoson, N., Boerth, N., Koretzky, G.A. and Shimizu, Y.: Cutting edge: a novel function for the SLAP-130 adapter protein in beta1 integrin signaling and T lymphocyte migration. J. Immunol. 2000; 164:1143-1147.

• Finkelstein, L.D. and Shimizu, Y.: The role of phosphoinositide 3-OH kinase and the cbl adaptor protein in coupling the alpha4beta1 integrin to mitogen activated protein kinase signaling. Biochem. J. 2000; 345:385-392.

• Woods, M.L., Cabañas,C. and Shimizu, Y.: Activation-dependent changes in soluble fibronectin binding and expression of beta1 integrin activation epitopes in T cells: relationship to T cell adhesion and migration. Eur J. Immunol. 2000; 30:38-49.

• Epler, J.A., Liu, R. and Shimizu, Y.: From the ECM to the cytoskeleton and back: how integrins orchestrate T cell action. Dev. Immunol. 2000; 7:155-170.

• Adelsman, M.A., McCarthy, J.B. and Shimizu, Y.: Stimulation of beta1 integrin function by epidermal growth factor and heregulinbeta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase. Mol. Biol. Cell 1999; 10:2861-2878.

• Chen, C., Mobley, J.L., Dwir, O., Shimron, F., Grabovsky, V., Lobb, R.R., Shimizu, Y. and Alon, R.: High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow. J. Immunol. 1999; 162:1084-1095.

• Shimizu, Y., Rose, D.M. and Ginsberg, M.H.: Integrins in the immune system. Adv. Immunol. 1999; 72:325-380.

• Zell, T., Kivens, W.J., Kellermann, S.-A. and Shimizu, Y.: Regulation of integrin function by T cell activation: points of convergence and divergence. Immunol. Res. 1999; 20:127-145.

• Romzek, N.C, Harris, E.S., Dell, C.L., Skronek, J., Hasse, E., Reynolds, P.J., Hunt, S.W., III and Shimizu, Y.: Use of a beta1 integrin-deficient human T cell to identify beta1 integrin cytoplasmic domain sequences critical for integrin function. Mol. Biol. Cell 1998; 9:2715-2727.

• Zell, T., Warden, C.S., Chan, A.S.H., Cook, M.E., Dell, C.L., Hunt, S.W., III and Shimizu, Y.: Regulation of beta1 integrin-mediated adhesion by the Cbl adapter protein. Curr. Biol. 1998; 8:814-822.

• Kivens, W.J., Hunt, S.W., III, Mobley, J.L., Zell, T., Dell, C.L., Bierer, B.E. and Shimizu, Y.: Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphatidylinositol 3-kinase. Mol. Cell. Biol. 1998; 18:5291-5307.

• Finkelstein, L.D., Reynolds, P.J., Hunt, S.W., III and Shimizu, Y.: Structural requirements for beta1 integrin-mediated tyrosine phosphorylation in human T cells. J. Immunol. 1997; 159:5355-5363.

• Hunter, A.J. and Shimizu, Y.: alpha4beta1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn. J. Immunol. 1997; 159:4806-4814.

• Chan, A.S.H., Mobley, J.L., Fields, G.B. and Shimizu, Y.: CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of phosphatidylinositol 3-kinase. J. Immunol. 1997; 159:934-942.

• Shimizu, Y. and Hunt, S.W., III: Regulating integrin-mediated adhesion: one more function for PI 3-kinase? Immunol. Today 1996; 17:565-573.

• Zell, T., Hunt, S.W., III, Mobley, J.L., Finkelstein, L.D. and Shimizu, Y.: CD28-mediated upregulation of beta1 integrin adhesion involves phosphatidylinositol 3-kinase. J. Immunol. 1996; 156:883-886.

• Mobley, J.L., Ennis, E. and Shimizu, Y.: Isolation and characterization of cell lines with genetically distinct mutations downstream of protein kinase C that result in defective activation-dependent regulation of T cell integrin function. J. Immunol. 1996; 156:948-956.

• Shimizu, Y., Mobley, J.L., Finkelstein, L.D. and Chan, A.S.H.: A role for phosphatidylinositol 3-kinase in the regulation of beta1 integrin activity by the CD2 antigen. J. Cell Biol. 1995; 131:1867-1880.

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