Original Research Publications
Cancer imaging
Jaiswal S, Wang F, Wu X, Chang TS, Shirazi A, Lee M, Dame MK, Spence JR, Wang TD. Near-Infrared In Vivo Imaging of Claudin-1 Expression by Orthotopically Implanted Patient-Derived Colonic Adenoma Organoids. Diagnostics 2024;14:273. PMC10854921.
Chang TS, Chen J, Kwon RS, Jiang Y, Seibel EJ, Turgeon DK, Wang TD. Targeted detection of Barrett’s neoplasia: A case report. Global Translational Medicine 2024;2223. PMID.
Wu X, Chen CW, Jaiswal S, Chang TS, Zhang R, Dame MK, Duan Y, Jiang H, Spence JR, Hsieh SY, Wang TD. Near-Infrared Imaging of Colonic Adenomas In Vivo Using Orthotopic Human Organoids for Early Cancer Detection. Cancers 2023;15:4795. PMC10571995.
Chang TS, Zhou Y, Zhang R, Kwon RS, Wamsteker EJ, Turgeon DK, Seibel EJ, Wang TD. Flexible fiber cholangioscope for detection of near-infrared fluorescence. VideoGIE 2022;8:110-112, PMC10019950.
Jiang Y, Chen J, Gong C, Wang TD, Seibel EJ. Deep-Learning-Based Real-Time and Automatic Target-to-Background Ratio Calculation in Fluorescence Endoscopy for Cancer Detection and Localization. Diagnostics. 2022;12:2031. PMC9497969.
Chen J, Jiang Y, Chang TS, Rubenstein JH, Kwon RS, Wamsteker EJ, Prabhu A, Zhao L, Appelman HD, Owens SR, Beer DG, Turgeon DK, Seibel EJ, Wang TD. Detection of Barrett’s neoplasia with near-infrared fluorescent heterodimeric peptide: feasibility results from a phase 1 study. Endoscopy 2022;54:1198-1204. PMC9718637.
Wu X, Meng X, Chang TS, Feng S, Lee M, Jaiswal S, Choi EY, Tran L, Jiang H, Wang TD. Multi-modal imaging for uptake of peptide ligand specific for CD44 by hepatocellular carcinoma. Photoacoustics 2022; 26:100355. PMC9035732.
Jaiswal S, Joshi BP, Chen J, Wang F, Dame MK, Spence JR, Newsome GM, Katz KL, Shah YM, Ramakrishnan SK, Li G, Lee M, Appelman HD, Kuick R, Wang TD. Membrane bound peroxiredoxin-1 serves as a biomarker for in vivo detection of sessile serrated adenomas, Antioxidants and Redox Signaling 2022;36:39-56. PMC8792500.
Chen J, Nguyen VP, Jaiswal S, Kang X, Lee M, Paulus YM, Wang TD. Thin Layer Protected Gold Nanoparticles for Targeted Photoacoustic/CT Imaging, Pharmaceuticals 2021;14:1075. PMC8624483.
Feng S, Meng X, Li Z, Chang TS, Wu X, Zhou J, Joshi BP, Choi EY, Zhao L, Zhu J, Wang TD. Multi-modal imaging probe for glypican-3 overexpressed in orthotopic hepatocellular carcinoma. Journal of Medicinal Chemistry 2021;64:15639-15650. PMC9007039.
Nojkov B, Zhou SY, Dolan RD, Davis EM, Appelman HD, Guo X, Jackson K, Sturm MB, Wang TD, Owyang C, Liu JJ, Chey WD. Evidence of Duodenal Epithelial Barrier Impairment and Increased Pyroptosis in Patients With Functional Dyspepsia on Confocal Laser Endomicroscopy and "Ex Vivo" Mucosa Analysis. Am J Gastroenterol 2020;115:1891-1901. PMC8409129.
Chen J, Jiang Y, Chang TS, Joshi BP, Rubenstein JH, Wamsteker EJ, Kwon RS, Appelman HD, Beer DG, Turgeon DK, Seibel EJ, Wang TD. Multiplexed endoscopic imaging of Barrett’s neoplasia using targeted fluorescent heptapeptides in a phase 1 proof-of-concept study. Gut 2021;70:1010-13. PMC8108279.
Sturm MB, Joshi BP, Owens SR, Seibel EJ, Wang TD. Multiplexed Imaging Strategy to Distinguish Indeterminant Biliary Strictures: An Ex Vivo Study. World Journal of Gastroenterology, Hepatology and Endoscopy 2020;3:1-7.
Wang F, Duan X, Chen J, Gao Z, Zhou J, Wu X, Chang TS, Lee M, Li G, Nusrat A, Kuick R, Appelman HD, Wang TD. Integrated imaging methodology detects claudin-1 expression in pre-malignant non-polypoid and polypoid colonic epithelium in mice. Clinical Translational Gastroenterology 2020;11:e00089. PMC7056050.
Wu X, Zhou J, Wang F, Meng X, Chen J, Chang TS, Lee M, Li G, Li X, Appelman HD, Kuick R, Wang TD. Detection of colonic neoplasia in vivo using near-infrared-labeled peptide targeting c-Met. Scientific Reports 2019;9:17917. PMC6884535.
Feng S, Zhou J, Li Z, Appelman HD, Zhao L, Zhu J, Wang TD. Sorafenib encapsulated in nanocarrier functionalized with glypican-3 specific peptide for targeted therapy of hepatocellular carcinoma. Colloids and Surfaces B: Biointerfaces 2019:184:110498. PMID: 31536939.
Ferrer-Torres D, Nancarrow DJ, Steinberg H, Wang Z, Kuick R, Weh KM, Mills RE, Ray D, Ray P, Lin J, Chang AC, Reddy RM, Orringer MB, Canto MI, Shaheen N, Kresty LA, Chak A, Wang TD, Rubenstein JH, Beer DG. Constitutively Higher Levels of GSTT2 in Esophageal Tissues From African Americans Protects Cells Against DNA Damage. Gastroenterology 2019;156:1404-1415. PMC6441633.
Ma X, Kang X, He L, Zhou J, Zhou J, Sturm MB, Beer DG, Kuick R, Nancarrow DJ, Appelman HD, Pang Z, Li W, Zhang C, Zhang W, Zhang Y, Wang TD, Li M. Identification of tumor specific peptide as EpCAM ligand and its potential diagnostic and therapeutic clinical application, Molecular Pharmaceutics 2019;16:2199-2213. PMID: 30974945.
Chen J, Gao Z, Li G, Wang TD. Dual-modal in vivo fluorescence and photoacoustic imaging using heterodimeric peptide, Chemical Communication 2018;54, 13196-99. PMC6357226.
Chen J, Zhou J, Gao Z, Li X, Wang F, Duan X, Li G, Joshi BP, Kuick R, Appelman HD, Wang TD. Multiplexed targeting of Barrett's neoplasia with a heterobivalent ligand: imaging study on mouse xenograft in vivo and human specimens ex vivo. Journal of Medicinal Chemistry 2018;61:5323-5331. PMC6542277.
Tavakkoli A, Appelman HD, Beer DG, Madiyal C, Khodadost M, Nofz K, Metko V, Elta G, Wang TD, Rubenstein JH. Use of Appropriate Surveillance for Patients With Nondysplastic Barrett's Esophagus. Clinical Gastroenterology & Hepatology 2018;16:862-869. PMC5962402.
Chen Y, Zhou Q, Li X, Wang F, Heist K, Kuick R, Owens SR, Wang TD. Ultra-small iron oxide nanoprobe for EGFR-targeted MRI of hepatocellular carcinoma in vivo. Bioconjugate Chemistry 2017;28:2794-2803. PMID: 28972742.
Zhou J, He L, Pang Z, Appelman HD, Kuick R, Beer DG, Li M, Wang TD. Identification and Validation of FGFR2 Peptide for Detection of Early Barrett’s Neoplasia. Oncotarget 2017;8:87095–87106. PMC5675618.
Li W, Jia H, Wang J, Guan H, Li Y, Zhang D, Tang Y, Wang TD, Lu SY. A CD44-specific peptide, RP-1, reveals capacities of assisting diagnosis and predicting prognosis of gastric cancer. Oncotarget 2017;8:30063-76. PMC5444726.
Kim YG, Sakamoto K, Seo SU, Pickard JM, Gillilland MG, Pudlo NA, Hoosta M, Li X, Wang TD, Feehley T, Stefka AT, Schmidt TM, Martens EC, Fukuda S, Inohara N, Nagler CR, Núñez G. Neonatal Acquisition of Clostridia Species Controls Colonization Resistance Against Bacterial Pathogens, Science 2017;356:315-319. PMC6082366.
Joshi BP, Dai Z, Gao Z, Lee JH, Ghimire N, Chen J, Prabhu A, Wamsteker EJ, Kwon RS, Elta GH, Owens SR, Appelman HD, Kuick R, Turgeon DK, Wang TD. Wide-field endoscopic imaging of sessile serrated adenomas with fluorescently-labeled peptide probe. Gastroenterology 2017;152:1002-13. PMC5771498.
Jiang Y, Gong Y, Rubenstein JH, Wang TD, Seibel EJ. Toward real-time quantification of fluorescence molecular probes using target/background ratio for guiding biopsy and endoscopic therapy of esophageal neoplasia. J Med Imaging 2017;4:024502. PMC5443417.
Zhou Q, Li Z, Zhou J, Joshi BP, Li G, Duan X, Kuick R, Owens SR, Wang TD. In Vivo Photoacoustic Tomography of EGFR Overexpressed in Hepatocellular Carcinoma Mouse Xenograft, Photoacoustics 2016;4:43-54. PMC5066077.
Xue X, Ramakrishnan SK, Weisz K, Triner D, Xie L, Pant A, Győrffy B, Zhan M, Carter-Su C, Hardiman KM, Wang TD, Dame M, Varani J, Brenner D, Fearon ER, Shah YM. Iron Accumulation via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis. Cell Metabolism 2016, 24:447-61. PMC5023486.
Ferrer-Torres D, Nancarrow DJ, Kuick R, Thomas DG, Nadal E, Lin J, Chang AC, Reddy RM, Orringer MB, Taylor JMG, Wang TD, Beer DG. Genomic similarity between gastroesophageal junction and esophageal Barrett's adenocarcinomas, Oncotarget 2016;7:54867-82. PMC5342387.
Zhang D, Jia H, Wang Y, Li WM, Hou YC, Yin SW, Wang TD, He SX, Lu SY. A CD44 specific peptide developed by phage display for targeting gastric cancer. Biotechnology Letters 2015; 37:2311-30. PMID: 26140900.
Zhou J, Joshi BP, Duan X, Pant A, Kuick R, Owens SR, Wang TD. EGFR overexpressed in colonic neoplasia can be detected on wide-field endoscopic imaging, Clinical Translational Gastroenterology 2015;6:e102. PMC4816258.
Lin J, Myers AL, Wang Z, Nancarrow DJ, Ferrer-Torres D, Handlogten A, Leverenz K, Bao J, Thomas DG, Wang TD, Orringer MB, Rishindra MR, Chang A, Beer DG, Lin L. Osteopontin (OPN/SPP1) isoforms collectively enhance tumor cell invasion and dissemination in esophageal adenocarcinoma. Oncotarget 2015;6:22239-57. PMC4673160.
Khondee S, Rabinsky EF, Owens SR, Joshi BP, Qiu Z, Duan X, Zhao L, Wang TD. Targeted therapy of colorectal neoplasia with rapamycin encapsulated in peptide-labeled pegylated octadecyl lithocholate micelles, Journal of Controlled Release 2015;199:114-21. PMC4308466.
Li JJ, Shan HB, He LJ, Wang TD, Xiong H, Chen LM, Li XH, Huang XX, Luo GY, Li Y, Xu GL. Extraesophageal saline enhances endoscopic ultrasonography to differentiate esophagus and adjacent organs. World Journal of Gastroenterology 2014;20:12551-8. PMC4168090.
Leicht DT, Kausar T, Wang Z, Ferrer-Torres D, Wang TD, Thomas DG, Lin J, Chang AC, Lin L, Beer DG. TGM2: A Cell Surface Marker in Esophageal Adenocarcinomas. J Thorac Oncol 2014;9:872-81. PMC4170218.
Atreya R, Neumann H, Neufert C, Waldner MJ, Billmeier U, Zopf Y, Willma M, App C, Münster T, Kessler H, Maas S, Gebhardt B, Heimke-Brinck R, Reuter E, Dörje F, Rau TT, Uter W, Wang TD, Kiesslich R, Vieth M, Hannappel E, Neurath MF. In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. Nature Medicine 2014;20:313-8. PMC4479137.
Sturm MB, Joshi BP, Lu S, Piraka C, Khondee S, Elmunzer BJ, Kwon RS, Beer DG, Appelman HD, Turgeon DK, Wang TD. Targeted endoscopic imaging of Barrett’s neoplasia with specific fluorescent-labeled peptide: first in-human results. Science Translational Medicine 2013;5:184ra61. PMC3859345.
Sturm MB, Piraka C, Elmunzer BJ, Kwon RS, Joshi BP, Appelman HD, Turgeon DK, Wang TD. In vivo molecular imaging of Barrett’s esophagus with confocal laser endomicroscopy. Gastroenterology 2013;145:56-8. PMC3818787.
Joshi BP, Miller SJ, Lee CM, Seibel EJ, Wang TD. Multispectral endoscopic imaging of colorectal dysplasia in vivo. Gastroenterology 2012;143:135-7. PMC3547605.
Miller SJ, Heist KA, Feng Y, Galban CJ, Rehemtulla A, Ross BD, Fearon ER, Wang TD. Multi-Modal Temporal Imaging of Growth and Rapamycin-Induced Regression in a Mouse Apc Mutation-dependent Colon Tumorigenesis Model, Translational Oncology 2012;5:313-20. PMC3468922.
Joshi BP, Liu Z, Elahi SF, Appelman HD, Wang TD. Near-infrared-labeled peptide multimer functions as phage-mimic for high affinity, specific targeting of colonic adenomas in vivo, Gastrointestinal Endoscopy 2012;76:1197-206. PMC3502727.
Zhang WJ, Sui YX, Budha A, Zheng JB, Sun XJ, Hou YC, Wang TD, Lu SY. Affinity peptide developed by phage display selection for targeting gastric cancer. World J Gastroenterol 2012;18:2053-60. PMC3342603.
Miller SJ, Lee CM, Joshi BP, Gaustad A, Seibel EJ, Wang TD. Targeted detection of murine colonic dysplasia in vivo with flexible multi-spectral scanning fiber endoscopy. J Biomedical Optics 2012;17:021103. PMC3380821.
Safdarian N, Liu Z, Zhou X, Appelman H, Nostrant T, Wang TD, Wang ET. Quantifying Human Eosinophils using 3-Dimensional Volumetric Images Collected with Multi-Photon Fluorescence Microscopy, Gastroenterology 2012;142:15-20. PMC3244565.
Safdarian N, Liu Z, Wang TD, Wang ET. Identification of nasal eosinophils using two-photon excited fluorescence. Annals of Allergy, Asthma & Immunology 2011;106:394-400. PMC4266399.
Miller SJ, Joshi B, Gaustad A, Feng Y, Fearon ER, Wang TD. In vivo Fluorescence-Based Endoscopic Detection of Colon Dysplasia in the Mouse using a Novel Peptide Probe, PLoS One 2011;6: e17384. PMC3050896.
Li M, Qin X, Xue X, Zhang C, Yan Z, Han W, Komarck C, Wang TD, Zhang Y. Safety Evaluation and Pharmacokinetics of a Novel Human Tumor Necrosis Factor-Alpha Exhibits Higher Anti-Tumor Activity and Lower Systemic Toxicity, Anti-Cancer Drugs 2010;21:243-51. PMC4266396.
Li M, Anastassiades CP, Joshi B, Komarck CM, Piraka C, Elmunzer BJ, Turgeon DK, Johnson TD, Appelman H, Beer DG, Wang TD. Affinity peptide for targeted detection of dysplasia in Barrett's esophagus. Gastroenterology 2010;139:1472-80. PMC3319360.
Lu S, Lowe AW, Triadafilopoulos G, Hsiung P, Hao Y, Crawford JM, Wang TD. Endoscopic evaluation of esophago-gastro-jejunostomy in rat model of Barrett's esophagus. Diseases of the Esophagus 2009;22:323-330. PMC3221518.
Hsiung P, Hardy J, Friedland S, Soetikno R, Du CB, Wu AP, Sahbaie P, Crawford JM, Lowe AW, Contag CH, Wang TD. Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy. Nature Medicine 2008;14:454-58. PMC3324975.
Brand S, Wang TD, Schomacker, KT, Poneros JM, Lauers GY, Compton CC, Pedrosa MC, Nishioka NS. Detection of High-Grade Dysplasia in Barrett’s Esophagus Spectroscopic Measurement 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence. Gastrointestinal Endoscopy 2002;56:479-87. PMID: 12297761.
Wang TD, Crawford JM, Wang Y, Itzkan I, Feld MS, Van Dam J. In Vivo Identification of Colonic Dysplasia using Fluorescence Endoscopic Imaging. Gastrointestinal Endoscopy 1999; 49:447-55. PMID: 10202057.
Imaging instruments
Li T, Chang TS, Shirazi A, Wu X, Lin WK, Zhang R, Guo JL, Oldham KR, Wang TD. Scaling down the dimensions of a Fabry-Perot polymer film acoustic sensor for photoacoustic endoscopy. Journal of Biomedical Optics 2024;S1:S11514. PMC10760494.
Li G, Lee M, Chang TS, Yu J, Li H, Duan X, Wu X, Jaiswal S, Feng S, Oldham KR, Wang TD. Wide-field endoscope accessory for multiplexed fluorescence imaging. Scientific Reports 2023;13:19527. PMC10636199.
Shirazi A, Sahraeibelverdi T, Lee M, Li H, Yu J, Jaiswal S, Oldham KR, Wang TD. Miniaturized side-view dual axes confocal endomicroscope for repetitive in vivo imaging. Biomedical Optics Express 2023;14:4277. PMC10549747.
Lee M, Li G, Li H, Duan X, Birla MB, Chang TS, Turgeon DK, Oldham KR, Wang TD. Confocal laser endomicroscope with distal MEMS scanner for real-time histopathology. Scientific Reports 2022;12:20155. PMC9684518.
Birla M, Zou J, Afkhami Z, Duan X, Li H, Wang TD, Oldham KR. Multi‐photon 3D imaging with an electrothermal actuator with low thermal and inertial mass. Sensors and Actuators A: Physical 2021;329:112791.
Birla M, Duan, X, Li H, Lee M, Li G, Wang TD, Oldham KR. Image processing metrics for phase identification of a multi-axis MEMS scanner used in single-pixel imaging. IEEE/ASME Transactions on Mechatronics 2021;26:1445-54. PMC8293905.
Chen Y, Lee M, Birla M, Li H, Li G, Duan, X, Wang TD, Oldham KR. Motion Estimation for a Compact Electrostatic Micro-scanner via Shared Driving and Sensing Electrodes in Endomicroscopy. IEEE Transactions on Mechatronics 2020;25:661-72. PMC7831447.
Li G, Duan X, Lee M, Birla M, Chen J, Oldham KR, Wang TD, Li H. Ultra-Compact Microsystems-Based Confocal Endomicroscope. IEEE Transactions on Medical Imaging 2020;39:2406-14. PMC7918297.
Chen Y, Li H, Qiu Z, Wang TD, Oldham KR. Improved Extended Kalman Filter Estimation using Threshold Signal Detection with a MEMS Electrostatic Micro-Scanner. IEEE Transactions on Industrial Electronics 2020;67:1328-36. PMC8340920.
Li H, Barnes P, Harding E, Duan X, Wang TD, Oldham KR. Large-Displacement Vertical Electrostatic Microactuator Dynamics using Duty-Cycled Softening/Stiffening Parametric Resonance. J Micromechanics and Microengineering 2019;28:351-61. PMC7451138.
Li H, Oldham KR, Wang TD. 3 degree-of-freedom resonant scanner with full-circumferential range and large out-of-plane displacement. Optics Express 2019;27:16296-16307. PMC6825615.
Choi J, Wang TD, Oldham KR. Dynamics of thin-film piezoelectric microactuators with large vertical stroke subject to multi-axis coupling and fabrication asymmetries. J Micromechanics and Microengineering 2017;28:015014. PMC6104405.
Duan X, Li H, Wang F, Li X, Oldham KR, Wang TD. Three-dimensional side-view endomicroscope for tracking individual cells in vivo. Biomedical Optics Express 2017;8:5533-5545. PMC5745101.
Gao Z, Li G, Li X, Zhou J, Duan X, Chen J, Joshi BP, Kuick R, Khoury B, Thomas DG, Fields T, Sabel MS, Appelman HD, Zhou Q, Li H, Kozloff K, Wang TD. In vivo near-infrared imaging of ErbB2 expressing breast tumors with dual-axes confocal endomicroscopy using a targeted peptide. Scientific Reports 2017;7:14404. PMC5663926.
Choi J, Duan X, Li H, Wang TD, Oldham KR. Multi-Photon Vertical Cross-Sectional Imaging With a Dynamically-Balanced Thin-Film PZT Z-Axis Microactuator. IEEE Journal of Microelectromechanical Systems 2017;99:1018-29. PMC5790190.
Jiang Y, Gong Y, Rubenstein JH, Wang TD, Seibel EJ. Toward real-time quantification of fluorescence molecular probes using target/background ratio for guiding biopsy and endoscopic therapy of esophageal neoplasia. J Med Imaging 2017;4:024502. PMC5443417.
Li G, Li H, Duan X, Zhou Q, Zhou J, Oldham KR, Wang TD. Visualizing Epithelial Expression in Vertical and Horizontal Planes With Dual Axes Confocal Endomicroscope Using Compact Distal Scanner. IEEE Transactions on Medical Imaging 2017;36:1482-90. PMID: 28252391.
Savastano LE, Zhou Q, Smith A, Vega K, Murga-Zamalloa C, Gordon D, McHugh J, Zhao L, Wang M, Pandey A, Thompson BG, Xu J, Zhang J, Chen YE, Seibel EJ, Wang TD. Multimodal laser-based angioscopy for structural, chemical, and biological imaging of atherosclerosis. Nature Biomedical Engineering 2017;1:0023. PMC5446210.
Duan X, Li H, Li X, Oldham KR, Wang TD. Axial beam scanning in multiphoton microscopy with MEMS-based actuator. Optics Express 2017;25:2195-2205. PMC5772401.
Savastano LE, Chaudhary N, Murga-Zamalloa C, Wang M, Wang TD, Thompson BG. Diagnostic and Interventional Optical Angioscopy in Ex Vivo Carotid Arteries. Operative Neurosurgery 2017;13:36-46. PMID: 28931265.
Duan X, Li H, Zhou J, Zhou Q, Oldham KR, Wang TD. Visualizing epithelial expression of EGFR in vivo with distal scanning side-viewing confocal endomicroscope. Scientific Reports 2016;6:37315. PMC5118792.
Li Z, Zhou Q, Zhou J, Duan X, Zhu J, Wang TD. In vivo fluorescence imaging of hepatocellular carcinoma xenograft using near-infrared labeled epidermal growth factor receptor (EGFR) peptide, Biomedical Optics Express 2016;9: 3163-69. PMC5030001.
Joshi BP, Pant A, Duan X, Prabhu A, Wamsteker EJ, Kwon RS, Elta GH, Owens SR, Appelman HD, Wang TD, Turgeon DK. Multi-modal video colonoscope for targeted wide-field detection of non-polypoid colorectal neoplasia. Gastroenterology 2016;150:1084-86. PMC5011973.
Rabinsky EF, Joshi BP, Zhou J, Duan X, Pant A, Kuick R, Fan S, Nusrat A, Owens SR, Appelman HD, Wang TD. Claudin-1 peptide can detect colonic neoplasia in vivo on endoscopic imaging, Cellular and Molecular Gastroenterology and Hepatology 2016;2:222-37. PMC4980721.
Joshi BP, Zhou J, Pant A, Duan X, Zhou Q, Kuick R, Owens SR, Appelman HD, Wang TD. Design and Synthesis of Near-Infrared Peptide for In Vivo Molecular Imaging of HER2, Bioconjugate Chemistry 2016;27:481-94. PMC5384256.
Joshi BP, Duan X, Rabinsky EF, Piraka C, Elmunzer BJ, Kwon RS, Lu S, Beer DG, Appelman HD, Owens SR, Kuick R, Doguchi N, Turgeon DK, Wang TD. Multi-modal endoscopy can quantify wide-field fluorescence detection of Barrett’s neoplasia. Endoscopy 2016;48:A1-13. PMC5011967.
Li H, Qiu Z, Duan X, Oldham K, Kurabayashi K, Wang TD. Integrated Monolithic 3D MEMS Scanner for Switchable Real-time Vertical/Horizontal Cross-sectional Imaging in Dual Axes Confocal Endomicroscope. Optics Express 2016;24:2145-55. PMC5802237.
Duan X, Li H, Qiu Z, Joshi BP, Pant A, Smith A, Kurabayashi K, Oldham K, Wang TD. MEMS-based multiphoton endomicroscope for repetitive imaging of mouse colon. Biomedical Optics Express 2015;6:3074-82. PMC4541532.
Shahid W, Qiu Z, Duan X, Li H, Wang TD, Oldham KR. Modeling and Simulation of a Parametrically Resonant Micro-Mirror with Duty-Cycled Excitation. IEEE J of Microelectromechanical Systems 2014;23:1440-53. PMC4262121.
Choi J, Qiu Z, Rhee CH, Wang TD, Oldham KR. A three-degree-of-freedom thin-film PZT-actuated microactuator with a large out-of-plane displacement, J Micromechanics and Microengineering 2014:24: 075017. PMC4262122.
Qiu Z, Rhee CH, Choi J, Wang TD, Oldham KR. Large Stroke Vertical PZT Microactuator with High-Speed Rotational Scanning. IEEE J of Microelectromechanical Systems 2014;23:256-58. PMC4262091.
Qiu Z, Khondee S, Duan X, Li H, Mandella MJ, Joshi BP, Zhou Q, Owens SR, Kurabayashi K, Oldham K, Wang TD. Vertical cross-sectional imaging of colonic dysplasia in vivo with multi-spectral dual axes confocal endomicroscopy. Gastroenterology 2014;146:615-17. PMC4029422.
Qiu Z, Liu Z, Duan X, Khondee S, Joshi BP, Mandella MJ, Oldham K, Kurabayashi K, Wang TD. Targeted vertical cross-sectional imaging with handheld near-infrared dual axes confocal fluorescence endomicroscope. Biomedical Optics Express 2013;4:322-330. PMC3567718.
Liu Z, Miller SJ, Joshi BP, Wang TD. Targeted wide-field fluorescence imaging of colonic dysplasia with near-infrared octapeptide. Gut 2013;62:395-403. PMC3563943.
Piyawattanametha W, Ra H, Qiu Z, Friedland S, Liu JTC, Loewke K, Kino GS, Solgaard O, Wang TD, Mandella MJ, Contag CH. In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract, J Biomedical Optics 2012:17:021102. PMC3380818.
Domke J, Rhee CH, Liu Z, Wang TD, Oldham KR. Amplifying transmission and compact suspension for a low profile, large displacement piezoelectric microactuator, J Micromechanics Microengineering 2011;21:067004. PMC3505072.
Elahi SF, Miller SJ, Joshi B, Wang TD. Targeted imaging of colorectal dysplasia in living mice with fluorescence microendoscopy. Biomedical Optics Express 2011;2:981-6. PMC3072136.
Elahi SF, Liu Z, Luker KE, Kwon RS, Luker GD, Wang TD. Longitudinal Molecular Imaging with Single Cell Resolution of Disseminated Ovarian Cancer in Mice with a LED-based Confocal Microendoscope. Mol Imaging Biol 2010;13:1157-62. PMC3502045.
Qiu Z, Pulskamp JS, Lin X, Rhee CH, Wang TD, Polcawich RG, Oldham K. Large displacement vertical translational actuator based on piezoelectric thin films. J Micromechanics and Microengineering 2010;20:1-10. PMC4262113.
Katukuri V, Hargrove J, Miller S, Rahal K, Kao J, Zimmerman E, Wolters R, Wang TD. Detection of inflammation in DSS-induced colitis with Fourier transform infrared spectroscopy using a flexible optical fiber, Biomedical Optics Express 2010;1:1014-25. PMC3018051.
Mackanos MA, Hargrove JT, Wolters R, Du C, Friedland S, Soetikno RM, Contag CH, Arroyo MR, Crawford JM, Wang TD. Use of an Endoscope Compatible Probe to Detect Colonic Dysplasia with Fourier Transform Infrared (FTIR) Spectroscopy. J Biomedical Optics 2009;14: 044006-1-9. PMC3232016.
Liu J, Mandella MJ, Crawford JM, Contag CH, Wang TD, Kino GS. Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-NA optics in a dual-axes confocal architecture. J Biomedical Optics 2008;13:034020. PMID: 18601565.
Ra H, Piyawattanametha W, Mandella MJ, Hsiung P, Hardy J, Wang TD, Contag CH, Kino GS, Solgaard O. Three-dimensional in vivo imaging by a handheld dual-axes confocal microscope. Optics Express 2008;16:7224-32. PMC2596951.
Sonn GA, Mach KE, Jensen K, Hsiung P, Jones S, Contag CH, Wang TD, Liao JC, Fibered Confocal Microscopy of Bladder Tumors: An Ex Vivo Study, J Endourology 2009;23: 197-201. PMC6469527.
Wang TD, Friedland S, Sahbaie P, Soetikno R, Hsiung P, Liu JTC, Crawford JM, Contag C. Functional Imaging of Colonic Mucosa with a Fibered Confocal Microscope for Real Time In Vivo Pathology, Clinical Gastroenterology & Hepatology 2007;5:1300-05. PMC2104519.
Wang TD, Triadafilopoulos G, Crawford JM, Dixon LR, Bhandari T, Sahbaie P, Friedland S, Soetikno R, Contag C. Detection of Endogenous Biomolecules in Barrett’s Esophagus by Fourier Transform Infrared Spectroscopy, Proc Natl Acad Sci 2007;104:40:15864-9. PMC2000401.
Wong LK, Mandella MJ, Kino GS, Wang TD. Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture, Optics Letters 2007;32:1674-6. PMC2104523.
Liu JTC, Mandella MJ, Ra H, Lee D, Kino GS, Solgaard O, Piyawatthanametha W, Contag CH, Wang TD. Miniature near-infrared dual-axes confocal microscope utilizing a two-dimensional microelectromechanical systems scanner, Optics Letters 2007;32:256-8. PMC2104518.
Liu JTC, Mandella MJ, Crawford JM, Friedland S, Soetikno R, Contag CH, Kino GS, Wang TD. A dual-axes confocal reflectance microscope for distinguishing colonic neoplasia. J Biomedical Optics 2006;11:054019-1-10. PMC2104521.
Wang TD, Contag CH, Mandella MJ, Chan NY, Kino GS. Confocal fluorescence microscope with dual-axis architecture and biaxial postobjective scanning. J Biomedical Optics 2004;9:735-42. PMC2104521.
Wang TD, Mandella MJ, Contag CH, Kino GS. Dual Axes Confocal Microscope with Post-Objective Scanning and Low Coherence Heterodyne Detection. Optics Letters 2003;28:1915-17. PMC2104522.
Wang TD, Mandella MJ, Contag CH, Kino GS. Dual Axes Confocal Microscope for High Resolution In Vivo Imaging. Optics Letters 2003;28:414-16. PMC2117897.
Wang TD, Janes S, Wang Y, Itzkan I, Van Dam J, Feld MS. Mathematical Model of Fluorescence Endoscopic Image Formation. Applied Optics 1998;37:8103-8111. PMID: 18301704.
Wang TD, Wang Y, Van Dam J, Crawford JM, Preisinger EA, Feld MS. Fluorescence Endoscopic Imaging for Detection of Human Colonic Adenomas. Gastroenterology 1996;111:1182-1191. PMID: 8898631.
