Sponsored Research Projects

Current extra-mural funding

R01 CA249851: PI TD Wang 10/01/20 – 09/30/25

NIH/NCI (Imaging and Biomarkers for Early Cancer Detection) “Early detection of colorectal cancer in the traditional and serrated pathways” The goal of the project is to establish proof-of-concept for a targeted imaging strategy to improve the effectiveness of colonoscopy for early colorectal cancer detection using a peptide multimer sensitive to pre-malignant lesions in the traditional and serrated pathways.

U01 EB028235: MPI TD Wang (contact) 09/01/19 – 08/30/24

NIH/NCI (Bioengineering Research Partnership) “Microsystems imaging system for epithelial-derived cancer heterogeneity. The goal of this project is to design, develop, and validate a microsystems-based scanner using high work density materials to perform random access control for imaging molecular heterogeneity of epithelial-derived cancers in pre-clinical models.

U01 CA230669: MPI AS Lok (contact) 09/01/18 – 08/30/23

NIH/NCI (Consortium on Translational Research in Early Detection of Liver Cancer) Novel Strategies to Improve Liver Cancer Surveillance Uptake and Early Detection The goal of this project is to assemble a team of specialists with complementary expertise in liver diseases, liver cancer, radiology, engineering, statistics, and information technology to improve liver cancer surveillance uptake in patients with cirrhosis.

U54 CA163059: PI TD Wang (contact) 05/27/17 – 04/30/22 (NCTE)

NIH/NCI (Barrett’s Esophagus Translational Research Network) Multi-Spectral Targeted Imaging for Early Detection of Cancer in Barrett’s Esophagus The Barrett’s Esophagus Translational Research Network (BETRNet) is a network of academic institutions that forms a multi-institutional, multi-disciplinary Specialized Research Resource to accelerate clinical translation of research in Barrett’s esophagus with improved access to biospecimens through a network-wide virtual biorepository, collective leveraging of novel animal and cellular models, genomics, proteomics and imaging.

Past extra-mural funding

R01 CA193377: PI TD Wang 05/15/16 – 04/30/21

NIH/NCI (Academic-Industrial Partnerships for Translation of In Vivo Imaging Systems) Early Detection of Colorectal Cancer on Near-Infrared Molecular Endoscopy The goal of this project is to develop an academic-industrial partnership with Olympus Medical Systems Corp to clinically translation a multi-modal colonoscope that is sensitive to near-infrared fluorescence for cancer investigation as a new method to perform improved early detection of colorectal cancer.

R01 CA200007: MPI EJ Seibel (contact) 07/14/15 – 06/30/20

NIH/NCI (Imaging and Biomarkers for Early Cancer Detection) Multiplexed Imaging of Biliary Intra-Epithelial Neoplasia The goal of this project is to develop a novel, multi-spectral imaging strategy that uses multiplexed detection with a panel of peptide monomers to improve methods for early detection of intra-epithelial neoplasia in the biliary tract.

U01 CA189291: PI TD Wang 07/01/15 – 06/30/19

NIH/NCI (Imaging and Biomarkers for Early Cancer Detection) Multiplexed Multi-Modal Endoscopic Imaging of Cancer Biomarkers The goal of this project is to develop a novel, multi-modal imaging strategy that uses the principle of multi-valency to perfrom multiplexed detection with a NIR-labeled peptide multimer to improve methods for early detection of esophageal adenocarcinoma.

R01 EB020644: PI KR Oldham 07/18/15 – 04/30/19

NIH/NCI (Bioengineering Research Grant) Multi-Photon Endomicroscope for Real-Time In Vivo Vertical Sectioning Role: Co-Investigator The goal of this project is to develop a novel scanning actuator that performs high speed random access interrogation of intra-epithelial biological behavior with large axial and lateral displacements in a multi-photon endomicroscope.

R01 CA142750: PI TD Wang 02/25/10 – 12/31/15

NIH/NCI (Bioengineering Research Partnership) Targeted Multi-Spectral Dual Axes Confocal Imaging of In Vivo Molecular Expression The goal of this collaboration between the College of Engineering and School of Medicine at the University of Michigan is to develop a novel intra-vital imaging strategy that provides vertical cross-sectional images to study molecular changes in the epithelium of small animal models of cancer.

U54 CA136429: MPI TD Wang (contact) 09/29/08 – 08/31/14

NIH/NCI (Network for Translational Research) In Vivo Detection of Neoplasia in the Digestive Tract The Network for Translational Research (NTR) is a multi-institutional, multi-disciplinary Specialized Research Resource Center that aims to optimize and validate novel, multi-modal methodologies using optical imaging platforms for early cancer detection.

P50 CA93990: MPI BD Ross (contact) 09/22/08 – 03/30/14

NIH/NCI (In Vivo Cellular and Molecular Imaging Center) Title: In Vivo Imaging of Neoplasia The aim of this project is to develop novel peptide probes and high resolution optical imaging instruments for longitudinal study of colorectal cancer in the pre-clinical and clinical setting.

R33 CA1109988: PI TD Wang 07/01/04 – 06/30/09

NIH/NCI (Novel Technologies for In Vivo Imaging) Miniature Confocal Theta Fluorescence Microscope The goal of this project is to miniaturize a tabletop microscope based on the confocal theta optical design into a handheld instrument for in vivo imaging with Micro-Electro-Mechanical-Systems (MEMS) technology.

R03 DK075603: PI TD Wang 7/01/06-6/30/09

NIH/NIDDK (Small Grant Program for K08/K23 Recipients) Development of Peptide Reagents for Detection of Colonic Dysplasia. The goal of this project is to develop peptide ligands that bind specifically to cell surface targets overexpressed by transformed epithelial cells.

K08 DK067618: PI TD Wang 09/01/03-12/31/08

NIH/NIDDK (Mentored Physician Scientist Development Award) Novel Confocal Microscope for Molecular/Cellular Imaging. The goal of this project is to develop a novel optical configuration for a confocal endomicroscope to image with deep tissue penetration.